Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Petit Paitel, Agnès ^a   Ménard, Baptiste ^a   Guyon, Alice ^a   Béringue, Vincent ^b   Nahon, Jean Louis ^a   Zsürger, Nicole ^a   Chabry, Joëlle ^a  

^a CNRS   (France)

^b INRA Institut National de la Recherche Agronomique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PRION PROTEIN; PROTEIN TYROSINE KINASE; CENTRAL DEPRESSANT AGENT; FYN PROTEIN, MOUSE; NR2B NMDA RECEPTOR; PRNP PROTEIN, MOUSE; PROTEIN KINASE FYN;

ALCOHOL SENSITIVITY; ALCOHOL TOLERANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CHEMOSENSITIVITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE OVEREXPRESSION; HIPPOCAMPUS; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LIPID RAFT; MOUSE; NONHUMAN; PRION DISEASE; PROTEIN FUNCTION; SEDATION; SIGNAL TRANSDUCTION; SYNAPSE; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; DRUG EFFECT; DRUG TOLERANCE; GENETICS; HAMSTER; HUMAN; IN VITRO STUDY; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PRION; PROTEIN TRANSPORT;

ANIMALS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CRICETINAE; DRUG TOLERANCE; ETHANOL; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHORYLATION; PRIONS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84859937536     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034691     Document Type: Article

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