Retinoic acid induces malformations related to cell death in the developing mouse embryo

Journal of Reproduction and Development

Volumn 43, Issue 1, 1997, Pages 59-64

  Okuda, Tomohiko ^a   Takakuwa, Hiroaki ^a   Mikami, Makiko ^a   Miyamoto, Hajime ^a   Manabe, Noboru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Cell death; Malformation; Mouse embryo; Retinoic acid; Tail and limb buds

Indexed keywords

EID: 11244354971     PISSN: 09168818     EISSN: 13484400     Source Type: Journal    
DOI: 10.1262/jrd.43.59     Document Type: Article

References (17)

1. Thompson JN, Nowell JM, Pitt GAJ. Vitamin A and reproduction in rats. Proc Royal Soc 1964; 159: 510-535.
2. Cohlan SQ. Excessive intake of vitamin A as a cause of congenital anomalies in the rat. Science 1953; 117: 535-537.
3. Yasuda Y, Okamoto M, Konishi H, Matsuo T, Kihara T, Tanimura T. Developmental anomalies induced by all-trans retinoic acid in fetal mice: I. Macroscopic findings. Teratology 1986; 34: 37-50.
4. Alles AJ, Sulik KK. Retinoic acid-induced limbreduction defects: Ferturbation of zones of programmed cell death as a pathogenetic mechanism. Teratology 1989; 40: 163-171.
5. Alles AJ, Sulik KK. Retinoic acid-induced spina bifida: Evidence for a pathogenetic mechanism. Development 1990; 108: 73-81.
6. Petkovich M, Brand NJ, Krust A, Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330: 440-450.
7. Giguére V, Ong ES, Segui P, Evans RM. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330: 624-629.
8. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992; 68: 397-406.
9. Allenby G, Bocquel M-T, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA. Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 1993; 90: 30-34.
10. Zelent A, Krust A, Petkovich P, Kastner P, Chambon P. Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 1989; 339: 714-717.
11. Ruberte E, Dolle P, Chambon P, Morriss-Kay G. Retinoic acid receptors and cellular retinoid binding proteins II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 1991; 111: 45-60.
12. Ruberte E, Dolle P, Krust A, Zelent A, Morriss-Kay G, Chambon P. Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development 1990; 108: 213-222.
13. Kwasigroch TE, Skaiko RG, Church JK. Mouse limb bud development in submerged culture: Quantitative assessment of the effects of in vivo exposure to retinoic acid. Teratog Carcinog Mutagen 1984; 4: 311-326.
14. Tibbies L, Wiley MJ. A comparative study of the effect of retinoic acid given during the critical period for inducing spina bifida in mice and hamsters. Teratology 1988; 37: 113-125.
15. Kwasigroch TE, Bullen M. Effects of isotretinoin (13-cis-retinoic acid) on the development of mouse limbs in vivo and in vitro. Teratology 1991; 44: 605616.
16. Nowack E. Die sensible phase bei der thalidomideembryopathie. Humangenetik 1965; 1: 516-536.
17. Francis BM, Rogers JM, Sulik KK, Alles AJ, Elstein KH, Zucker RM, Massaro EJ, Rosen MB, Chernoff N. Cyclophosphamide teratogenesis: evidence for compensatory responses to induced cellular toxicity. Teratology 1990; 42: 473-482.