Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: Role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism

Behavioural Brain Research

Volumn 232, Issue 1, 2012, Pages 66-76

  Tota, Santoshkumar ^a,b   Nath, Chandishwar ^a   Najmi, Abul Kalam ^b   Shukla, Rakesh ^a   Hanif, Kashif ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Angiotensin converting enzyme; CBF; Memory impairment; Morris water maze; Passive avoidance; Scopolamine

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; MALONALDEHYDE; MESSENGER RNA; PERIGARD; PERINDOPRIL; SCOPOLAMINE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HIPPOCAMPUS; LASER DOPPLER FLOWMETRY; MALE; MAZE TEST; MEMORY DISORDER; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLCHOLINESTERASE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; AVOIDANCE LEARNING; BRAIN CHEMISTRY; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MOTOR ACTIVITY; MUSCARINIC ANTAGONISTS; OXIDATIVE STRESS; PARASYMPATHETIC NERVOUS SYSTEM; PEPTIDYL-DIPEPTIDASE A; PERINDOPRIL; SCOPOLAMINE HYDROBROMIDE; SYNAPTIC TRANSMISSION;

EID: 84859929771     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.03.015     Document Type: Article

References (44)

1. Wright J.W., Harding J.W. The brain RAS and Alzheimer's disease. Exp Neurol 2011, 223:326-333.
2. Fogari R., Mugellini A., Zoppi A., Derosa G., Pasotti C., Fogari E., et al. Influence of losartan and atenolol on memory function in very elderly hypertensive patients. J Hum Hypertens 2003, 17:781-785.
3. Li N.C., Lee A., Whitmer R.A., Kivipelto M., Lawler E., Kazis L.E., et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 2011, 340:b5465.
4. Smakotina S.A., Trubnikova O.A., Anan'ko Iu.A., Barbarash O.L. Effect of perindopril on cognitive functions in young and middle aged patients with hypertensive disease. Kardiologiia 2008, 48:28-33.
5. Davies N.M., Kehoe P.G., Ben-Shlomo Y., Martin R.M. Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias. J Alzheimer's Dis 2011, 26:699-708.
6. Saxby B.K., Harrington F., Wesnes K.A., McKeith I.G., Ford G.A. Candesartan and cognitive decline in older patients with hypertension: a substudy of the SCOPE trial. Neurology 2008, 70:1858-1866.
7. Kehoe P.G. The renin-angiotensin-aldosterone system and Alzheimer's disease. J Renin Angiotensin Aldosterone Syst 2003, 4:80-93.
8. Kehoe P.G., Miners S., Love S. Angiotensins in Alzheimer's disease-friend or foe. Trends Neurosci 2009, 32:619-628.
9. Arregui A., Perry E.K., Rossor M., Tomlinson B.E. Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas. J Neurochem 1982, 38:1490-1492.
10. Savaskan E. The role of the brain renin-angiotensin system in neurodegenerative disorders. Curr Alzheimer Res 2005, 2:29-35.
11. Savaskan E., Hock C., Olivieri G., Bruttel S., Rosenberg C., Hulette C., et al. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol Aging 2001, 22:541-546.
12. He M., Ohrui T., Maruyama M., Tomita N., Nakayama K., Higuchi M., et al. ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease. Neurology 2006, 67:1309-1310.
13. Tota S., Kamat P.K., Saxena G., Hanif K., Najmi A.K., Nath C. Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats. Behav Brain Res 2011, 226:317-330.
14. Costall B., Coughlan J., Horovitz Z.P., Kelly M.E., Naylor R.J., Tomkins D.M. The effects of ACE inhibitors captopril and SQ29,852 in rodent tests of cognition. Pharmacol Biochem Behav 1989, 33:573-579.
15. Manschot S.M., Biessels G.J., Cameron N.E., Cotter M.A., Kamal A., Kappelle L.J., et al. Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats. Brain Res 2003, 966:274-282.
16. Basso N., Paglia N., Stella I., de Cavanagh E.M., Ferder L., del Rosario Lores Arnaiz M., et al. Protective effect of the inhibition of the renin-angiotensin system on aging. Regul Pept 2005, 128:247-252.
17. Srinivasan J., Jayadev S., Kumaran D., Ahamed K.F., Suresh B., Ramanathan M. Effect of losartan and enalapril on cognitive deficit caused by Goldblatt induced hypertension. Indian J Exp Biol 2005, 43:241-246.
18. Wyss J.M., Kadish I., van Groen T. Age-related decline in spatial learning and memory: attenuation by captopril. Clin Exp Hypertens 2003, 25:455-474.
19. Hou D.R., Wang Y., Zhou L., Chen K., Tian Y., Song Z., et al. Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease. Chin Med J (Engl) 2008, 121:2320-2323.
20. Kumaran D., Udayabanu M., Kumar M., Aneja R., Katyal A. Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats. Neuroscience 2008, 155:626-639.
21. Gerhardt P., Hasenohrl R.U., Hock F.J., Huston J.P. Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain. Psychopharmacology (Berl) 1993, 111:442-448.
22. Barnes J.M., Barnes N.M., Costall B., Horovitz Z.P., Ironside J.W., Naylor R.J., et al. Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition. Brain Res 1990, 507:341-343.
23. Musial A., Bajda M., Malawska B. Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. Curr Med Chem 2007, 14:2654-2679.
24. Sivaprakasam K. Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation. Curr Med Chem 2006, 13:2179-2188.
25. Honer W.G., Prohovnik I., Smith G., Lucas L.R. Scopolamine reduces frontal cortex perfusion. J Cereb Blood Flow Metab 1988, 8:635-641.
26. Tota S., Awasthi H., Kamat P.K., Nath C., Hanif K. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behav Brain Res 2010, 209:73-79.
27. Wyper D., Teasdale E., Patterson J., Montaldi D., Brown D., Hunter R., et al. Abnormalities in rCBF and computed tomography in patients with Alzheimer's disease and in controls. Br J Radiol 1993, 66:23-27.
28. Awasthi H., Tota S., Hanif K., Nath C., Shukla R. Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. Life Sci 2010, 86:87-94.
29. Kulkarni K.S., Kasture S.B., Mengi S.A. Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats. Indian J Pharmacol 2010, 42:168-173.
30. Liem-Moolenaar M., de Boer P., Timmers M., Schoemaker R.C., van Hasselt J.G., Schmidt S., et al. Pharmacokinetic-pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects. Br J Clin Pharmacol 2011, 71:886-898.
31. Sharma D., Puri M., Tiwary A.K., Singh N., Jaggi A.S. Antiamnesic effect of stevioside in scopolamine-treated rats. Indian J Pharmacol 2010, 42:164-167.
32. Molchan S.E., Matochik J.A., Zametkin A.J., Szymanski H.V., Cantillon M., Cohen R.M., et al. A double FDG/PET study of the effects of scopolamine in older adults. Neuropsychopharmacology 1994, 10:191-198.
33. Jenkins T.A., Chai S.Y. Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats. Neurobiol Learn Mem 2007, 87:218-224.
34. Tota S, Hanif K, Kamat PK, Najmi AK, Nath C. Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function. Psychopharmacology (Berl), . doi:10.1007/s00213-012-2639-7.
35. Tota S., Kamat P.K., Awasthi H., Singh N., Raghubir R., Nath C., et al. Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin. Behav Brain Res 2009, 199:235-240.
36. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
37. Wang C., Smith R.L. Lowry determination of protein in the presence of Triton X-100. Anal Biochem 1975, 63:414-417.
38. Pachauri S.D., Tota S., Khandelwal K., Verma P.R., Nath C., Hanif K., et al. Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: a behavioral, biochemical and cerebral blood flow study. J Ethnopharmacol 2012, 139:34-41.
39. Nazir F.S., Overell J.R., Bolster A., Hilditch T.E., Lees K.R. Effect of perindopril on cerebral and renal perfusion on normotensives in mild early ischaemic stroke: a randomized controlled trial. Cerebrovasc Dis 2005, 19:77-83.
40. Faraci F.M., Heistad D.D. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 1998, 78:53-97.
41. Ertl G., Hu K. Anti-ischemic potential of drugs related to the renin-angiotensin system. J Cardiovasc Pharmacol 2001, 37(Suppl. 1):S11-S20.
42. Agrawal R., Tyagi E., Shukla R., Nath C. Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice. Behav Brain Res 2008, 189:381-386.
43. Hanif K., Snehlata Pavar M.C., Arif E., Biswas P., Fahim M., et al. Effect of 3-thienylalanine-ornithine-proline, new sulfur-containing angiotensin-converting enzyme inhibitor on blood pressure and oxidative stress in spontaneously hypertensive rats. J Cardiovasc Pharmacol 2009, 53:145-150.
44. Ferreira I.L., Resende R., Ferreiro E., Rego A.C., Pereira C.F. Multiple defects in energy metabolism in Alzheimer's disease. Curr Drug Targets 2011, 11:1193-1206.