Photodynamic therapy of pheophorbide a inhibits the proliferation of human breast tumour via both caspase-dependent and -independent apoptotic pathways in in vitro and in vivo models

Phytotherapy Research

Volumn 26, Issue 5, 2012, Pages 734-742

  Hoi, Sandy Wan Heng ^a   Wong, Hoi Ming ^a   Chan, Judy Yuet Wa ^a   Yue, Grace Gar Lee ^a   Tse, Gary Man Kit ^a   Law, Bonita Ka Bo ^b   Fong, Wing Ping ^a   Fung, Kwok Pui ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Union Hospital   (Hong Kong)

Author keywords

apoptosis; breast cancer; MCF 7; Pheophorbide a; photodynamic therapy

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE 9; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHEOPHORBIDE A; PLANT MEDICINAL PRODUCT; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; MITOCHONDRION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PROTEIN CLEAVAGE; SCUTELLARIA; SCUTELLARIA BARBATA; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHLOROPHYLL; CYTOCHROMES C; DNA FRAGMENTATION; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SCUTELLARIA; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859917495     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3607     Document Type: Article

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