Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy

Cancer Research

Volumn 62, Issue 15, 2002, Pages 4289-4294

  Dolmans, Dennis E J G J ^a   Kadambi, Ananth ^a   Hill, John S ^b   Flores, Kevin R ^b   Gerber, Joseph N ^b   Walker, Jeffrey P ^b   Borel Rinkes, Inne H M ^c   Jain, Rakesh K ^a   Fukumura, Dai ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Miravant Medical Technologies   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MV 6401; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CANCER LOCALIZATION; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG HALF LIFE; FEMALE; FRACTIONATION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RADIATION ENERGY; SPECTRAL SENSITIVITY; TISSUE DISTRIBUTION; TUMOR BLOOD FLOW; VASCULARIZATION;

ADENOCARCINOMA; ANIMALS; DRUG ADMINISTRATION SCHEDULE; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, SCID; NEOVASCULARIZATION, PATHOLOGIC; ORGANOMETALLIC COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 0036682018     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Photodynamic therapy
2. An evaluation of photodynamic therapy in the management of cutaneous metastases of breast cancer
3. A Phase II/III clinical study of tin ethyl etiopurpurin (Purlytin)-induced photodynamic therapy for the treatment of recurrent cutaneous metastatic breast cancer
4. Photodynamic therapy for chest wall progression from breast carcinoma is an underutilized treatment modality
5. How does photodynamic therapy work?
6. Tumor induction of VEGF promoter activity in stromal cells
7. In vivo fluence rate and fractionation effects on tumor response and photobleaching: Photodynamic therapy with two photosensitizers in an orthotopic rat tumor model
8. Photodynamic therapy for peritoneal carcinomatosis
9. Photoradiation therapy causing selective tumor kill in a rat glioma model
10. Vascular accumulation of a novel photosensitizer MV6401 causes selective thrombosis in tumor vessels following photodynamic therapy
11. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: Mammary fat pad versus cranial tumors
12. Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation
13. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice
14. Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions
15. Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft
16. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen
17. Targeting of the tumor microcirculation by photodynamic therapy with a synthetic porphycene
18. Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma
19. Improvement of systemic 5-amindevulinic acid-based photodynamic therapy in vivo using light fractionation with a 75-minute interval
20. Effectiveness of δ-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo
21. Radiation enhancement by 9-aminocamptothecin. Evidence for improved therapeutic ratio with a multiple dose schedule
22. Non-invasive monitoring of photodynamic therapy with 99technetium HMPAO, scintigraphy
23. Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers
24. Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a
25. Sites of photodamage in vivo and in vitro by a cationic porphyrin
26. Photosensitization of murine tumor, vasculature and skin by 5-aminolevulinic acid-induced porphyrin
27. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution
28. Dissecting tumour pathophysiology using intravital microscopy