Future medicine shaped by an interdisciplinary new biology

The Lancet

Volumn 379, Issue 9825, 2012, Pages 1544-1550

  O'Shea, Paul ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BIOLOGY; HUMAN; INTERDISCIPLINARY RESEARCH; MEDICAL TECHNOLOGY; NANOMEDICINE; NANOTECHNOLOGY; PHYSICS; PRIORITY JOURNAL; REVIEW;

EID: 84859916596     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)60476-0     Document Type: Review

References (40)

1. Davidovits P. Physics in biology and medicine. 3rd edn. London: Academic Press, 2007.
2. Hood L. A personal journey of discovery: developing technology and changing biology. Annu Rev Anal Chem 2008; 1: 1-43.
3. Nobe D. Biophysics and systems biology. Philos Trans A Math Phys Eng Sci 2010; 368: 1125-39.
4. Lazebnik Y. Can a biologist fix a radio?\or, what I learned while studying apoptosis. Cancer Cell 2002; 2: 179-82.
5. Birks JB. Rutherford at Manchester. London: Heywood and Co, 1962.
6. Nobelprize.org. The Nobel Prize in chemistry. 1908. Ernest Rutherford. http://www.nobelprize.org/nobel-prizes/chemistry/laureates/1908/(accessed April 10, 2012).
7. Keevil SF. Physics and medicine: a historical perspective. Lancet 2012; published online April 18. DOI:10.1016/S0140-6736(11)60282-1.
8. Morris P, Perkins A. Diagnostic imaging. Lancet 2012; published online April 18. DOI:10.1016/S0140-6736(12)60429-2.
9. Melzer A, Cochran S, Prentice P, MacDonald MP, Wang Z, Cuschieri A. The importance of physics to progress in medical treatment. Lancet 2012; published online April 18. DOI:10.1016/S0140-6736(12)60428-0.
10. West GB. The importance of quantitative systemic thinking in medicine. Lancet 2012; published online April 18. DOI:10.1016/S0140-6736(12)60281-5.
11. Kitano H. Systems biology: a brief overview. Science 2002; 295: 1662-64.
12. European Science Foundation. Advancing Systems Biology for Medical Applications. http://www.esf.org/nc/research-areas/medical-sciences/activities/ science-policy/advancing-systems-biology-for-medical-applications.html (accessed March 30, 2012)
13. Royal Academy of Engineering. Systems biology: a vision for engineering and medicine. A report from the Academy of Medical Sciences and The Royal Academy of Engineering. http://www. acmedsci.ac.uk/images/pressRelease/ 1170256174.pdf (April 10, 2012).
14. Ideker T, Galitski T, Hood L. A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet 2001; 2: 343-72.
15. Kell DB. Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov Today 2006; 11: 1085-92.
16. Richens JL, Urbanowicz RA, Lunt EAM, et al. Systems biology coupled with high-throughput screening as a novel approach for diagnosis of chronic obstructive pulmonary disease (COPD). Respir Res 2009; 22: 10-29.
17. Kell DB, Oliver SG. Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays 2004; 26: 99-105.
18. Schmid EF, Smith DA. Keynote review: is declining innovation in the pharmaceutical industry a myth? Drug Discov Today 2005; 10: 1031-39.
19. Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004; 3: 711-15.
20. Kell DB. The virtual human: towards a global systems biology of multiscale, distributed biochemical network models. IUBMB Life 2007; 59: 689-95.
21. O'Hagan S, Dunn WB, Brown M, Knowles JD, Kell DB. Closed-loop, multiobjective optimisation of analytical instrumentation: gas-chromatography- time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. Anal Chem 2005; 77: 290-303.
22. Broadhurst D, Kell DB. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2006; 2: 171-96.
23. Vere K, Richens J, Somekh M, Bajaj N, Morgan K, O'Shea P. Plasmonic-array-based biosensors for the diagnosis of neurodegenerative diseases. Funct Opt Imaging 2011. DOI:10.1109/FOI.2011.6154818.
24. O'Shea P, Somekh MG, Barnes WL. Shedding light on life; visualising nature's complexity. Physics World 2008; 21: 29-34.
25. Duarte NC, Becker SA, Jamshidi N, et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci USA 2007; 104: 1777-82.
26. Sadiq SK, Mazzeo MD, Zasada SJ, et al. Patient-specific simulation as a basis for clinical decision-making. Philos Trans A Math Phys Eng Sci 2008; 366: 3199-219.
27. Stein L. Creating a bioinformatics nation. Nature 2002; 417: 119-20.
28. Farrar JT. Advances in clinical research methodology for pain clinical trials. Nat Med 2010; 16: 1284-93.
29. Berner ES. Clinical decision support systems: theory and practice. New York: Springer, 1999.
30. van der Greef J, Hankemeier T, McBurney RN. Metabolomics-based systems biology and personalized medicine: moving towards n=1 clinical trials? Pharmacogenomics 2006; 7: 1087-94.
31. Vafadar-Isfahani B, Ball G, Coveney C, et al. Identification of SPARC-like 1 protein as part of a biomarker panel for Alzheimer's disease in cerebrospinal fluid. J Alzheimers Dis 2012; 28: 625-36.
32. Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature 2004; 429: 464-68.
33. Kell DB, Mendes P. The markup is the model: reasoning about systems biology models in the Semantic Web era. J Theoret Biol 2008; 252: 538-43.
34. McLuhan M, Fiore Q. The medium is the message. London: Penguin Books, 1971.
35. McNeil SE. Nanotechnology for the biologist. J Leulloc Biol 2005; 78: 585-94.
36. Melin J, Quake SR. Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu Rev Biophys Biomol Struct 2007; 36: 213-31.
37. Wang ZL. Self-powered nanosensors and nanosystems. Adv Mater 2012; 24: 280-85.
38. Alexander A, Solovev, Wang Xi, et al. Self-propelled nanotools. ACS Nano 2012; 6: 1751-56
39. National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. Facilitating interdisciplinary research. Washington, DC: National Academies Press, 2004.
40. Allen S, Rigby-Singleton SM, Harris H, O'Shea P. Measuring and visualizing single molecular interactions. Biochem Soc Trans 2003; 31: 1052-57.