Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals

Pharmacogenetics and Genomics

Volumn 22, Issue 5, 2012, Pages 344-354

  Kato, Koji ^a   Kusuhara, Hiroyuki ^b   Kumagai, Yuji ^c   Ieiri, Ichiro ^d   Mori, Haruyuki ^a   Ito, Sumito ^b   Nakai, Yasuhiro ^a   Maeda, Kazuya ^b   Sugiyama, Yuichi ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KITASATO UNIVERSITY HOSPITAL   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

ATP binding cassette transporter; isoflavonoids; multidrug resistance associated protein 2; single nucleotide polymorphism; untargeted metabolomics

Indexed keywords

DAIDZEIN; DOCETAXEL; GENISTEIN; ISOFLAVONOID; MULTIDRUG RESISTANCE PROTEIN 2;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IN VIVO STUDY; JAPANESE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEMBRANE VESICLE; METABOLOMICS; NONHUMAN; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SINGLE NUCLEOTIDE POLYMORPHISM;

RATTUS;

EID: 84859908658     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283517012     Document Type: Article

References (35)

1. Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, et al. Membrane transporters in drug development. Nat Rev Drug Discov 2010; 9:215-236.
2. Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Archiv 2007; 453:643-659. (Pubitemid 46192536)
3. Borst P, Zelcer N, van de Wetering K. MRP2 and 3 in health and disease. Cancer Lett 2007; 234:51-61. (Pubitemid 43343940)
4. Ito K, Suzuki H, Horie T, Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res 2005; 22:1559-1577. (Pubitemid 41355896)
5. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, Ter Borg F, Scheper RJ, et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997; 25: 1539-1542. (Pubitemid 27250780)
6. Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K, et al. Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/ Dubin-Johnson syndrome. Hum Mol Genet 1998; 7:203-207. (Pubitemid 28048535)
7. Hoffmann U, Kroemer HK. The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 2004; 36:669-701. (Pubitemid 39453069)
8. Ieiri I, Higuchi S, Sugiyama Y. Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs. Expert Opin Drug Metab Toxicol 2009; 5:703-729.
9. Maeda K, Sugiyama Y. Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs. Drug Metab Pharmacokinet 2008; 23:223-235.
10. Naesens M, Kuypers DR, Verbeke K, Vanrenterghem Y. Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients. Transplantation 2006; 82:1074-1084. (Pubitemid 44632124)
11. Miura M, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T. Telmisartan pharmacokinetics in Japanese renal transplant recipients. Clin Chim Acta 2009; 399:83-87.
12. Daly AK, Aithal GP, Leathart JB, Swainsbury RA, Dang TS, Day CP. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Gastroenterology 2007; 132:272-281. (Pubitemid 46108755)
13. De Jong FA, Scott-Horton TJ, Kroetz DL, McLeod HL, Friberg LE, Mathijssen RH, et al. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 2007; 81:42-49. (Pubitemid 46050866)
14. Kim WJ, Lee JH, Yi J, Cho YJ, Heo K, Lee SH, et al. A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. Pharmacogenet Genomics 2010; 20:249-256.
15. Izzedine H, Hulot JS, Villard E, Goyenvalle C, Dominguez S, Ghosn J, et al. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis 2006; 194:1481-1491. (Pubitemid 44851889)
16. Wojnowski L, Kulle B, Schirmer M, Schluter G, Schmidt A, Rosenberger A, et al. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation 2005; 112:3754-3762. (Pubitemid 43739516)
17. Kiyotani K, Mushiroda T, Kubo M, Zembutsu H, Sugiyama Y, Nakamura Y. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci 2008; 99:967-972. (Pubitemid 351997599)
18. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 1997; 272:G16-G22.
19. Pluskal T, Castillo S, Villar-Briones A, Oresic M. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometrybased molecular profile data. BMC Bioinform 2010; 11:395.
20. Wiklund S, Johansson E, Sjöström L, Mellerowicz EJ, Edlund U, Shockcor JP, et al. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 2008; 80:115-122. (Pubitemid 351448411)
21. Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res 2009; 37:D603-D610.
22. Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000; 28:27-30. (Pubitemid 30047706)
23. Piskula MK. Soy isoflavone conjugation differs in fed and food-deprived rats. J Nutr 2000; 130:1766-1771. (Pubitemid 30451065)
24. Hirouchi M, Suzuki H, Itoda M, Ozawa S, Sawada J, Ieiri I, et al. Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. Pharm Res 2004; 21:742-748. (Pubitemid 39011294)
25. Kondo C, Suzuki H, Itoda M, Ozawa S, Sawada J, Kobayashi D, et al. Functional analysis of SNPs variants of BCRP/ABCG2. Pharm Res 2004; 21:1895-1903. (Pubitemid 39390103)
26. Kalliokoski A, Neuvonen PJ, Niemi M. SLCO1B1 polymorphism and oral antidiabetic drugs. Basic Clin Pharmacol Toxicol 2010; 107:775-781.
27. Ide T, Sasaki T, Maeda K, Higuchi S, Sugiyama Y, Ieiri I. Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic information on SLCO1B1 and ABCC2 polymorphisms. J Clin Pharmacol 2009; 49:1309-1317.
28. Coldham NG, Darby C, Hows M, King LJ, Zhang AQ, Sauer MJ. Comparative metabolism of genistin by human and rat gut microflora: detection and identification of the end-products of metabolism. Xenobiotica 2002; 32:45-62. (Pubitemid 34095133)
29. Kurisu H, Kamisaka K, Koyo T, Yamasuge S, Igarashi H, Maezawa H, et al. Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia. Life Sci 1991; 49:1003-1011.
30. Jäger W, Winter O, Halper B, Salamon A, Sartori M, Gajdzik L, et al. Modulation of liver canalicular transport processes by the tyrosine-kinase inhibitor genistein: implications of genistein metabolism in the rat. Hepatology 1997; 26:1467-1476. (Pubitemid 27520011)
31. Shimamura H, Suzuki H, Hanano M, Suzuki A, Tagaya O, Horie T, et al. Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 1994; 271:370-378. (Pubitemid 24333151)
32. Akao T, Sato K, Hanada M. Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat. Biol Pharm Bull 2009; 32:2079-2082.
33. Chen J, Lin H, Hu M. Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Cancer Chemother Pharmacol 2005; 55:159-169. (Pubitemid 40110059)
34. Kitamura Y, Kusuhara H, Sugiyama Y. Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine. J Pharmacol Exp Ther 2010; 332:659-666.
35. Adachi Y, Suzuki H, Schinkel AH, Sugiyama Y. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Mol Pharmacol 2005; 67:923-928. (Pubitemid 40365339)