Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing

Calcified Tissue International

Volumn 90, Issue 5, 2012, Pages 420-428

  Alford, Andrea I ^a   Reddy, Anita B ^a   Goldstein, Steven A ^a   Murthy, Prithvi ^a   Tayim, Riyad ^a,b   Sharma, Gorav ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Fracture; Marrow stromal cell; Matricellular; Osteoblast; Thrombospondin 2

Indexed keywords

THROMBOSPONDIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATIONAL STUDY; CULTURE MEDIUM; EXPERIMENTAL MOUSE; FEMALE; FRACTURE HEALING; GENE EXPRESSION; GENE FUNCTION; IN VITRO STUDY; MARKER GENE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; TIBIA FRACTURE; TISSUE DISTRIBUTION; TSP2 GENE; UPREGULATION;

ANIMALS; BONE DENSITY; DISEASE MODELS, ANIMAL; FEMALE; FRACTURE HEALING; FRACTURES, BONE; MICE; MICE, INBRED C57BL; MOLECULAR WEIGHT; THROMBOSPONDINS; TIBIA;

EID: 84859906688     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9580-y     Document Type: Article

References (27)

1. P Bornstein E Sage 2002 Matricellular proteins: extracellular modulators of cell function Curr Opin Cell Biol 14 608 616 12231357 10.1016/S0955-0674(02) 00361-7 1:CAS:528:DC%2BD38XmvVCrtbg%3D (Pubitemid 35247745)
2. P Bornstein LC Armstrong KD Hankenson TR Kyriakides Z Yang 2000 Thrombospondin 2, a matricellular protein with diverse functions Matrix Biol 19 557 568 11102746 10.1016/S0945-053X(00)00104-9 1:CAS:528:DC%2BD3MXhsFCmtA%3D%3D
3. KD Hankenson SD Bain TR Kyriakides EA Smith SA Goldstein P Bornstein 2000 Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2 J Bone Miner Res 15 851 862 10804014 10.1359/jbmr.2000.15.5.851 1:CAS:528:DC%2BD3cXjt1Crs7w%3D (Pubitemid 30233408)
4. KD Hankenson P Bornstein 2002 The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation J Bone Miner Res 17 415 425 11874233 10.1359/jbmr.2002.17.3.415 1:CAS:528:DC%2BD38XitVKht70%3D (Pubitemid 34171756)
5. AI Alford SP Terkhorn AB Reddy KD Hankenson 2010 Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts Bone 46 464 471 19744582 10.1016/j.bone.2009.08.058 1:CAS:528:DC%2BC3cXpslejsA%3D%3D
6. HS Shitaye SP Terkhorn JA Combs KD Hankenson 2010 Thrombospondin-2 is an endogenous adipocyte inhibitor Matrix Biol 29 549 556 20561899 10.1016/j.matbio.2010.05.006 1:CAS:528:DC%2BC3cXhtFGgsbzK
7. DK Taylor JA Meganck S Terkhorn R Rajani A Naik RJ O'Keefe SA Goldstein KD Hankenson 2009 Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing J Bone Miner Res 24 1043 1054 19123916 10.1359/jbmr.090101
8. OV Volpert SS Tolsma S Pellerin JJ Feige H Chen DF Mosher N Bouck 1995 Inhibition of angiogenesis by thrombospondin-2 Biochem Biophys Res Commun 217 326 332 8526929 10.1006/bbrc.1995.2780 1:CAS:528:DyaK2MXpvVWhsLo%3D (Pubitemid 26006308)
9. TR Kyriakides YH Zhu LT Smith SD Bain Z Yang MT Lin KG Danielson RV Iozzo M LaMarca CE McKinney EI Ginns P Bornstein 1998 Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis J Cell Biol 140 419 430 9442117 10.1083/jcb.140.2.419 1:CAS:528:DyaK1cXmsV2gtQ%3D%3D (Pubitemid 28078405)
10. A Hiltunen E Vuorio HT Aro 1993 A standardized experimental fracture in the mouse tibia J Orthop Res 11 305 312 8483044 10.1002/jor.1100110219 1:STN:280:DyaK3s3ks1yqtw%3D%3D (Pubitemid 23159359)
11. JE Aubin 1999 Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation J Cell Biochem 72 396 410 10022521 10.1002/(SICI)1097- 4644(19990301)72:3<396::AID-JCB9>3.0.CO;2-6 1:CAS:528:DyaK1MXnvFKiug%3D%3D (Pubitemid 29047402)
12. CB Carlson J Lawler DF Mosher 2008 Structures of thrombospondins Cell Mol Life Sci 65 672 686 18193164 10.1007/s00018-007-7484-1 1:CAS:528: DC%2BD1cXjsFOku7k%3D
13. NV Lee M Sato DS Annis JA Loo L Wu DF Mosher ML Iruela-Arispe 2006 ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 EMBO J 25 5270 5283 17082774 10.1038/sj.emboj.7601400 1:CAS:528:DC%2BD28Xht1Sgt7zN (Pubitemid 44764137)
14. T Lind N McKie M Wendel SN Racey MA Birch 2005 The hyalectan degrading ADAMTS-1 enzyme is expressed by osteoblasts and up-regulated at regions of new bone formation Bone 36 408 417 15777654 10.1016/j.bone.2004.11.008 1:CAS:528:DC%2BD2MXisFGrt7g%3D (Pubitemid 40403839)
15. AP Rehn MA Birch E Karlstrom M Wendel T Lind 2007 ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing Bone 41 231 238 17560840 10.1016/j.bone.2007.04.187 1:CAS:528:DC%2BD2sXnsFKku7c%3D (Pubitemid 47001821)
16. P Manduca A Castagnino D Lombardini S Marchisio S Soldano V Ulivi S Zanotti C Garbi N Ferrari D Palmieri 2009 Role of MT1-MMP in the osteogenic differentiation Bone 44 251 265 19027888 10.1016/j.bone.2008.10.046 1:CAS:528:DC%2BD1MXhtFSmtb4%3D
17. V Geoffroy C Marty-Morieux N Le Goupil P Clement-Lacroix C Terraz M Frain S Roux J Rossert MC de Vernejoul 2004 In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass J Bone Miner Res 19 811 822 15068505 10.1359/jbmr.040119 1:CAS:528:DC%2BD2cXktFGks70%3D (Pubitemid 41094393)
18. TR Kyriakides YH Zhu Z Yang P Bornstein 1998 The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice J Histochem Cytochem 46 1007 1015 9705966 10.1177/002215549804600904 1:CAS:528:DyaK1cXlvVKqsb4%3D (Pubitemid 28402481)
19. IA Bab TA Einhorn 1994 Polypeptide factors regulating osteogenesis and bone marrow repair J Cell Biochem 55 358 365 7962168 10.1002/jcb.240550313 1:CAS:528:DyaK2cXkslequ74%3D (Pubitemid 24218812)
20. I Bab D Gazit M Chorev A Muhlrad A Shteyer Z Greenberg M Namdar A Kahn 1992 Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity EMBO J 11 1867 1873 1582415 1:CAS:528:DyaK38XktVWktL0%3D
21. MA Brager MJ Patterson JF Connolly Z Nevo 2000 Osteogenic growth peptide normally stimulated by blood loss and marrow ablation has local and systemic effects on fracture healing in rats J Orthop Res 18 133 139 10716289 10.1002/jor.1100180119 1:CAS:528:DC%2BD3cXitVOitLY%3D
22. S Amsel A Maniatis M Tavassoli WH Crosby 1969 The significance of intramedullary cancellous bone formation in the repair of bone marrow tissue Anat Rec 164 101 111 5769818 10.1002/ar.1091640107 1:STN:280: DyaF1M7os1Onsw%3D%3D
23. D Gazit M Karmish L Holzman I Bab 1990 Regenerating marrow induces systemic increase in osteo- and chondrogenesis Endocrinology 126 2607 2613 2328701 10.1210/endo-126-5-2607 1:STN:280:DyaK3c3ivValtw%3D%3D (Pubitemid 20173054)
24. I Bab D Gazit A Massarawa J Sela 1985 Removal of tibial marrow induces increased formation of bone and cartilage in rat mandibular condyle Calcif Tissue Int 37 551 555 3933795 10.1007/BF02557840 1:STN:280: DyaL28%2Flt1ygtQ%3D%3D (Pubitemid 15250124)
25. RJ Pignolo M Kassem 2011 Circulating osteogenic cells: implications for injury, repair, and regeneration J Bone Miner Res 26 1685 1693 21538513 10.1002/jbmr.370 1:CAS:528:DC%2BC3MXhtVejtL7I
26. K Kumagai A Vasanji JA Drazba RS Butler GF Muschler 2008 Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model J Orthop Res 26 165 175 17729300 10.1002/jor.20477 (Pubitemid 351220134)
27. I Boban T Barisic-Dujmovic SH Clark 2010 Parabiosis model does not show presence of circulating osteoprogenitor cells Genesis 48 171 182 20127800 1:CAS:528:DC%2BC3cXkvVyitLo%3D