Thrombospondin-2 is an endogenous adipocyte inhibitor

Matrix Biology

Volumn 29, Issue 6, 2010, Pages 549-556

  Shitaye, Hailu S ^a,b   Terkhorn, Shawn P ^b   Combs, Jason A ^b   Hankenson, Kurt D ^b  

^a UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Extracellular matrix; Gene regulation; Knockout mouse; Matricellular protein; Mesenchymal progenitor; Thrombospondin 2

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THROMBOSPONDIN 2;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GENE EXPRESSION; GENE TARGETING; LIPID DIET; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; UPREGULATION; WEIGHT GAIN; WILD TYPE;

ABSORPTIOMETRY, PHOTON; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; INTRA-ABDOMINAL FAT; MICE; MICE, KNOCKOUT; OBESITY; OSTEOGENESIS; PPAR GAMMA; SUBCUTANEOUS FAT; THROMBOSPONDINS;

MUS;

EID: 77956459642     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2010.05.006     Document Type: Article

References (23)

1. Alford A.I., Terkhorn S.P., Reddy A.B., Hankenson K.D. Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Bone 2009, 46:464-471.
2. Bornstein P., Armstrong L.C., Hankenson K.D., Kyriakides T.R., Yang Z. Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biol. 2000, 19:557-568.
3. Bradshaw A.D., Graves D.C., Motamed K., Sage E.H. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:6045-6050.
4. Cooke P.S., Naaz A. Role of estrogens in adipocyte development and function. Exp. Biol. Med. (Maywood) 2004, 229:1127-1135.
5. Darlington G.J., Ross S.E., MacDougald O.A. The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem. 1998, 273:30057-30060.
6. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
7. Ferron M., Hinoi E., Karsenty G., Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:5266-5270.
8. Gimble J.M., Guilak F. Differentiation potential of adipose derived adult stem (ADAS) cells. Curr. Top. Dev. Biol. 2003, 58:137-160.
9. Hankenson K.D., Bornstein P. The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation. J. Bone Miner. Res. 2002, 17:415-425.
10. Hankenson K.D., Bain S.D., Kyriakides T.R., Smith E.A., Goldstein S.A., Bornstein P. Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J. Bone Miner. Res. 2000, 15:851-862.
11. Hankenson K.D., James I.E., Apone S., Stroup G.B., Blake S.M., Liang X., Lark M.W., Bornstein P. Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice. Matrix Biol. 2005, 24:362-370.
12. Hofmann S.M., Zhou L., Perez-Tilve D., Greer T., Grant E., Wancata L., Thomas A., Pfluger P.T., Basford J.E., Gilham D., Herz J., Tschöp M.H., Hui D.Y. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J. Clin. Invest. 2007, 117:3271-3282.
13. Kyriakides T.R., Zhu Y.H., Smith L.T., Bain S.D., Yang Z., Lin M.T., Danielson K.G., Iozzo R.V., LaMarca M., McKinney C.E., Ginns E.I., Bornstein P. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J. Cell Biol. 1998, 140:419-430.
14. Lee N.K., Sowa H., Hinoi E., Ferron M., Ahn J.D., Confavreux C., Dacquin R., Mee P.J., McKee M.D., Jung D.Y., Zhang Z., Kim J.K., Mauvais-Jarvis F., Ducy P., Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell 2007, 130:456-469.
15. Luo W., Shitaye H., Friedman M., Bennett C.N., Miller J., Macdougald O.A., Hankenson K.D. Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation. Exp. Cell Res. 2008, 314:3382-3391.
16. MacDougald O.A., Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 1995, 64:345-373.
17. Masson O., Chavey C., Dray C.d., Meulle A., Daviaud D., Quilliot D., Muller C., Valet P., Liaudet-Coopman E. LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue. PLoS ONE 2009, 4:e7422.
18. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., Chen C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 2004, 6:483-495.
19. Nie J., Sage E.H. SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. J. Biol. Chem. 2009, 284:1279-1290.
20. Ross S.E., Hemati N., Longo K.A., Bennett C.N., Lucas P.C., Erickson R.L., MacDougald O.A. Inhibition of adipogenesis by Wnt signaling. Science 2000, 289:950-953.
21. Sfeir Z., Ibrahimi A., Amri E., Grimaldi P., Abumrad N. Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transport. Prostaglandins Leukot. Essent. Fatty Acids 1997, 57:17-21.
22. Voros G., Maquoi E., Demeulemeester D., Clerx N., Collen D., Lijnen H.R. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 2005, 146:4545-4554.
23. Yang Z., Strickland D.K., Bornstein P. Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J. Biol. Chem. 2001, 276:8403-8408.