In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass

Journal of Bone and Mineral Research

Volumn 19, Issue 5, 2004, Pages 811-822

  Geoffroy, Valérie ^a   Marty Morieux, Caroline ^a   Le Goupil, Nathalie ^a   Clement Lacroix, Phillippe ^b   Terraz, Catherine ^c   Frain, Monique ^d   Roux, Sophie ^a   Rossert, Jérome ^c   De Vernejoul, Marie Christine ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b Proskelia Pharmaceuticals   (France)

^c HÔPITAL TENON   (France)

^d ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

Extracellular matrix; Low bone turnover; Matrix metalloproteinases; Mouse model; Osteoblast function

Indexed keywords

COMPLEMENTARY DNA; METALLOPROTEINASE; PARATHYROID HORMONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ALKALINE PHOSPHATASE; PROTEINASE INHIBITOR;

AGE DISTRIBUTION; ANALYTIC METHOD; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERALIZATION; BONE REMODELING; BONE TURNOVER; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; DENSITOMETRY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; HORMONAL REGULATION; IN VIVO STUDY; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; ORGAN CULTURE; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRABECULAR BONE; TRANSGENIC MOUSE; ANIMAL; BONE; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROMOTER REGION; RADIOGRAPHY; ULTRASTRUCTURE;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CELLS, CULTURED; FEMALE; MALE; METALLOPROTEASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTEASE INHIBITORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 3242806779     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040119     Document Type: Article

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