메뉴 건너뛰기




Volumn 209, Issue 2, 2010, Pages 234-240

Lack of involvement of alpha-synuclein in unconditioned anxiety in mice

Author keywords

Alpha synuclein; Anxiety; Elevated plus maze; Light dark box; Mice; Open field

Indexed keywords

ALPHA SYNUCLEIN;

EID: 77649236543     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.01.049     Document Type: Article
Times cited : (31)

References (47)
  • 2
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18 (1998) 106-108
    • (1998) Nat Genet , vol.18 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3    Woitalla, D.4    Graeber, M.5    Kosel, S.6
  • 3
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5    Dutra, A.6
  • 5
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95 (1998) 6469-6473
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 6
    • 10744230149 scopus 로고    scopus 로고
    • The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
    • Zarranz J.J., Alegre J., Gomez-Esteban J.C., Lezcano E., Ros R., Ampuero I., et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55 (2004) 164-173
    • (2004) Ann Neurol , vol.55 , pp. 164-173
    • Zarranz, J.J.1    Alegre, J.2    Gomez-Esteban, J.C.3    Lezcano, E.4    Ros, R.5    Ampuero, I.6
  • 7
    • 24344470188 scopus 로고    scopus 로고
    • Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    • Peng X., Tehranian R., Dietrich P., Stefanis L., and Perez R.G. Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. J Cell Sci 118 (2005) 3523-3530
    • (2005) J Cell Sci , vol.118 , pp. 3523-3530
    • Peng, X.1    Tehranian, R.2    Dietrich, P.3    Stefanis, L.4    Perez, R.G.5
  • 8
    • 0037092442 scopus 로고    scopus 로고
    • A role for alpha-synuclein in the regulation of dopamine biosynthesis
    • Perez R.G., Waymire J.C., Lin E., Liu J.J., Guo F., and Zigmond M.J. A role for alpha-synuclein in the regulation of dopamine biosynthesis. J Neurosci 22 (2002) 3090-3099
    • (2002) J Neurosci , vol.22 , pp. 3090-3099
    • Perez, R.G.1    Waymire, J.C.2    Lin, E.3    Liu, J.J.4    Guo, F.5    Zigmond, M.J.6
  • 9
    • 33846856920 scopus 로고    scopus 로고
    • RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport
    • Fountaine T.M., and Wade-Martins R. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. J Neurosci Res 85 (2007) 351-363
    • (2007) J Neurosci Res , vol.85 , pp. 351-363
    • Fountaine, T.M.1    Wade-Martins, R.2
  • 10
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
    • Lee F.J., Liu F., Pristupa Z.B., and Niznik H.B. Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J 15 (2001) 916-926
    • (2001) FASEB J , vol.15 , pp. 916-926
    • Lee, F.J.1    Liu, F.2    Pristupa, Z.B.3    Niznik, H.B.4
  • 11
    • 0037451858 scopus 로고    scopus 로고
    • Attenuation of dopamine transporter activity by alpha-synuclein
    • Wersinger C., and Sidhu A. Attenuation of dopamine transporter activity by alpha-synuclein. Neurosci Lett 340 (2003) 189-192
    • (2003) Neurosci Lett , vol.340 , pp. 189-192
    • Wersinger, C.1    Sidhu, A.2
  • 12
    • 36149000595 scopus 로고    scopus 로고
    • Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats
    • Boyer F., and Dreyer J.L. Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. Eur J Neurosci 26 (2007) 2764-2776
    • (2007) Eur J Neurosci , vol.26 , pp. 2764-2776
    • Boyer, F.1    Dreyer, J.L.2
  • 13
    • 0037390023 scopus 로고    scopus 로고
    • Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons
    • Mash D.C., Ouyang Q., Pablo J., Basile M., Izenwasser S., Lieberman A., et al. Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. J Neurosci 23 (2003) 2564-2571
    • (2003) J Neurosci , vol.23 , pp. 2564-2571
    • Mash, D.C.1    Ouyang, Q.2    Pablo, J.3    Basile, M.4    Izenwasser, S.5    Lieberman, A.6
  • 14
    • 27744520577 scopus 로고    scopus 로고
    • Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum
    • Qin Y., Ouyang Q., Pablo J., and Mash D.C. Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum. Neuroreport 16 (2005) 1489-1493
    • (2005) Neuroreport , vol.16 , pp. 1489-1493
    • Qin, Y.1    Ouyang, Q.2    Pablo, J.3    Mash, D.C.4
  • 15
    • 0242708673 scopus 로고    scopus 로고
    • Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment
    • Brenz Verca M.S., Bahi A., Boyer F., Wagner G.C., and Dreyer J.L. Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. Eur J Neurosci 18 (2003) 1923-1938
    • (2003) Eur J Neurosci , vol.18 , pp. 1923-1938
    • Brenz Verca, M.S.1    Bahi, A.2    Boyer, F.3    Wagner, G.C.4    Dreyer, J.L.5
  • 16
    • 20144389039 scopus 로고    scopus 로고
    • Occurrence of neuronal inclusions combined with increased nigral expression of alpha-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice
    • Fornai F., Lenzi P., Ferrucci M., Lazzeri G., di Poggio A.B., Natale G., et al. Occurrence of neuronal inclusions combined with increased nigral expression of alpha-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice. Brain Res Bull 65 (2005) 405-413
    • (2005) Brain Res Bull , vol.65 , pp. 405-413
    • Fornai, F.1    Lenzi, P.2    Ferrucci, M.3    Lazzeri, G.4    di Poggio, A.B.5    Natale, G.6
  • 17
    • 0037446854 scopus 로고    scopus 로고
    • alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats
    • Liang T., Spence J., Liu L., Strother W.N., Chang H.W., Ellison J.A., et al. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc Natl Acad Sci USA 100 (2003) 4690-4695
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4690-4695
    • Liang, T.1    Spence, J.2    Liu, L.3    Strother, W.N.4    Chang, H.W.5    Ellison, J.A.6
  • 18
  • 22
    • 33644847525 scopus 로고    scopus 로고
    • Anxiety disorders in Parkinson's disease
    • Richard I.H. Anxiety disorders in Parkinson's disease. Adv Neurol 96 (2005) 42-55
    • (2005) Adv Neurol , vol.96 , pp. 42-55
    • Richard, I.H.1
  • 23
    • 0033925871 scopus 로고    scopus 로고
    • Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study
    • Shiba M., Bower J.H., Maraganore D.M., McDonnell S.K., Peterson B.J., Ahlskog J.E., et al. Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study. Mov Disord 15 (2000) 669-677
    • (2000) Mov Disord , vol.15 , pp. 669-677
    • Shiba, M.1    Bower, J.H.2    Maraganore, D.M.3    McDonnell, S.K.4    Peterson, B.J.5    Ahlskog, J.E.6
  • 24
    • 0035141144 scopus 로고    scopus 로고
    • Parkinson's disease and anxiety
    • Walsh K., and Bennett G. Parkinson's disease and anxiety. Postgrad Med J 77 (2001) 89-93
    • (2001) Postgrad Med J , vol.77 , pp. 89-93
    • Walsh, K.1    Bennett, G.2
  • 25
    • 22544441902 scopus 로고    scopus 로고
    • The relationship between social anxiety disorder and alcohol use disorders: a critical review
    • Morris E.P., Stewart S.H., and Ham L.S. The relationship between social anxiety disorder and alcohol use disorders: a critical review. Clin Psychol Rev 25 (2005) 734-760
    • (2005) Clin Psychol Rev , vol.25 , pp. 734-760
    • Morris, E.P.1    Stewart, S.H.2    Ham, L.S.3
  • 26
    • 33750160737 scopus 로고    scopus 로고
    • Social anxiety disorder in 300 patients hospitalized for alcoholism in Brazil: high prevalence and undertreatment
    • Terra M.B., Barros H.M., Stein A.T., Figueira I., Jorge M.R., Palermo L.H., et al. Social anxiety disorder in 300 patients hospitalized for alcoholism in Brazil: high prevalence and undertreatment. Compr Psychiatry 47 (2006) 463-467
    • (2006) Compr Psychiatry , vol.47 , pp. 463-467
    • Terra, M.B.1    Barros, H.M.2    Stein, A.T.3    Figueira, I.4    Jorge, M.R.5    Palermo, L.H.6
  • 27
    • 69249218053 scopus 로고    scopus 로고
    • Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety
    • Chiavegatto S., Izidio G.S., Mendes-Lana A., Aneas I., Freitas T.A., Torrao A.S., et al. Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. Mol Psychiatry 14 (2009) 894-905
    • (2009) Mol Psychiatry , vol.14 , pp. 894-905
    • Chiavegatto, S.1    Izidio, G.S.2    Mendes-Lana, A.3    Aneas, I.4    Freitas, T.A.5    Torrao, A.S.6
  • 29
    • 11444261071 scopus 로고    scopus 로고
    • Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein
    • Siegmund A., Langnaese K., and Wotjak C.T. Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein. Behav Brain Res 157 (2005) 291-298
    • (2005) Behav Brain Res , vol.157 , pp. 291-298
    • Siegmund, A.1    Langnaese, K.2    Wotjak, C.T.3
  • 31
    • 0008684585 scopus 로고    scopus 로고
    • Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice
    • Podhorna J., and Brown R.E. Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice. Genes Brain Behav 1 (2002) 96-110
    • (2002) Genes Brain Behav , vol.1 , pp. 96-110
    • Podhorna, J.1    Brown, R.E.2
  • 32
    • 0000650706 scopus 로고
    • The Open-Field Test: a critical review
    • Walsh R.N., and Cummins R.A. The Open-Field Test: a critical review. Psychol Bull 83 (1976) 482-504
    • (1976) Psychol Bull , vol.83 , pp. 482-504
    • Walsh, R.N.1    Cummins, R.A.2
  • 33
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl) 92 (1987) 180-185
    • (1987) Psychopharmacology (Berl) , vol.92 , pp. 180-185
    • Lister, R.G.1
  • 34
    • 0022620470 scopus 로고
    • Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat
    • Pellow S., and File S.E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24 (1986) 525-529
    • (1986) Pharmacol Biochem Behav , vol.24 , pp. 525-529
    • Pellow, S.1    File, S.E.2
  • 36
    • 0030782744 scopus 로고    scopus 로고
    • Anxiety, defence and the elevated plus-maze
    • Rodgers R.J., and Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 21 (1997) 801-810
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 801-810
    • Rodgers, R.J.1    Dalvi, A.2
  • 38
    • 0019199013 scopus 로고
    • Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
    • Crawley J., and Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 13 (1980) 167-170
    • (1980) Pharmacol Biochem Behav , vol.13 , pp. 167-170
    • Crawley, J.1    Goodwin, F.K.2
  • 39
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.H., Castillo P.E., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000) 239-252
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3    Choi-Lundberg, D.4    Ho, W.H.5    Castillo, P.E.6
  • 40
    • 2642553802 scopus 로고    scopus 로고
    • Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    • Robertson D.C., Schmidt O., Ninkina N., Jones P.A., Sharkey J., and Buchman V.L. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. J Neurochem 89 (2004) 1126-1136
    • (2004) J Neurochem , vol.89 , pp. 1126-1136
    • Robertson, D.C.1    Schmidt, O.2    Ninkina, N.3    Jones, P.A.4    Sharkey, J.5    Buchman, V.L.6
  • 41
    • 40549093026 scopus 로고    scopus 로고
    • Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    • Senior S.L., Ninkina N., Deacon R., Bannerman D., Buchman V.L., Cragg S.J., et al. Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci 27 (2008) 947-957
    • (2008) Eur J Neurosci , vol.27 , pp. 947-957
    • Senior, S.L.1    Ninkina, N.2    Deacon, R.3    Bannerman, D.4    Buchman, V.L.5    Cragg, S.J.6
  • 42
    • 0035789203 scopus 로고    scopus 로고
    • Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
    • Specht C.G., and Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neuroscience 2 (2001) 11-19
    • (2001) BMC Neuroscience , vol.2 , pp. 11-19
    • Specht, C.G.1    Schoepfer, R.2
  • 43
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R., Spillantini M.G., and Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett 345 (1994) 27-32
    • (1994) FEBS Lett , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 44
    • 0027429156 scopus 로고
    • A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation
    • Nakajo S., Tsukada K., Omata K., Nakamura Y., and Nakaya K. A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation. Eur J Biochem 217 (1993) 1057-1063
    • (1993) Eur J Biochem , vol.217 , pp. 1057-1063
    • Nakajo, S.1    Tsukada, K.2    Omata, K.3    Nakamura, Y.4    Nakaya, K.5
  • 45
    • 6944227811 scopus 로고    scopus 로고
    • Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
    • Chandra S., Fornai F., Kwon H.B., Yazdani U., Atasoy D., Liu X., et al. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci USA 101 (2004) 14966-14971
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14966-14971
    • Chandra, S.1    Fornai, F.2    Kwon, H.B.3    Yazdani, U.4    Atasoy, D.5    Liu, X.6
  • 46
    • 33847652983 scopus 로고    scopus 로고
    • Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein
    • Kuhn M., Haebig K., Bonin M., Ninkina N., Buchman V.L., Poths S., et al. Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein. Neurogenetics 8 (2007) 71-81
    • (2007) Neurogenetics , vol.8 , pp. 71-81
    • Kuhn, M.1    Haebig, K.2    Bonin, M.3    Ninkina, N.4    Buchman, V.L.5    Poths, S.6
  • 47
    • 0036150318 scopus 로고    scopus 로고
    • Genetic basis of anxiety-like behaviour: a critical review
    • Clement Y., Calatayud F., and Belzung C. Genetic basis of anxiety-like behaviour: a critical review. Brain Res Bull 57 (2002) 57-71
    • (2002) Brain Res Bull , vol.57 , pp. 57-71
    • Clement, Y.1    Calatayud, F.2    Belzung, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.