Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 2837-2844

  Wu, Peng ^a   Su, Yi ^a   Liu, Xiaowen ^a   Yang, Bo ^a   He, Qiaojun ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

2 Piperidinol 3 (arylsulfonyl)quinoxaline; Antitumor activity; pAkt; PI3K

Indexed keywords

2 (3,5 DIMETHOXYPHENYLAMINO) 3 (PHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 3 OL) 3 (4 BROMOPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 3 OL) 3 (4 FLUOROPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 3 OL) 3 (4 METHOXYPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 3 OL) 3 (4 METHYLPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 3 OL) 3 (ARYLSULFONYL)QUINOXALINE DERIVATIVE; 2 (PIPERIDIN 3 OL) 3 (PHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 4 OL) 3 (4 BROMOPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 4 OL) 3 (4 METHOXYPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 4 OL) 3 (4 METHYLPHENYLSULFONYL)QUINOXALINE; 2 (PIPERIDIN 4 OL) 3 (ARYLSULFONYL)QUINOXALINE DERIVATIVE; 2 (PIPERIDIN 4 OL) 3 (PHENYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (4 BROMOPHENYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (4 FLUOROPHENYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (4 METHOXYPHENYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (4 METHYLPHENYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (ARYLSULFONYL)QUINOXALINE; 2 [3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 3 (PHENYLSULFONYL)QUINOXALINE; 2 MORPHOLINO 3 PHENYLSULFONYLQUINOXALINE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 PIPERIDINOL 3 (ARYLSULFONYL)QUINOXALINE DERIVATIVE; 2 PYRROLIDINYL 3 (4 BROMOPHENYLSULFONYL)QUINOXALINE; 2 PYRROLIDINYL 3 (4 FLUOROPHENYLSULFONYL)QUINOXALINE; 2 PYRROLIDINYL 3 (4 METHOXYPHENYLSULFONYL)QUINOXALINE; 2 PYRROLIDINYL 3 (4 METHYLPHENYLSULFONYL)QUINOXALINE; 2 PYRROLIDINYL 3 (PHENYLSULFONYL)QUINOXALINE; 3 PIPERIDINOL; 4 HYDROXYPIPERIDINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859898773     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.026     Document Type: Article

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