Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans

Genes and Immunity

Volumn 13, Issue 3, 2012, Pages 258-267

  Seu, L ^a,b   Burt, T D ^b   Witte, J S ^b,c   Martin, J N ^b   Deeks, S G ^b   McCune, J M ^b  

^a San Francisco   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

heme oxygenase 1; HIV; microsatellite; monocytes; polymorphism; soluble CD14

Indexed keywords

ANTIRETROVIRUS AGENT; CD14 ANTIGEN; HEME OXYGENASE 1; HLA DR ANTIGEN; LIPOPOLYSACCHARIDE;

ADULT; AFRICAN AMERICAN; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; MONOCYTE; MORTALITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS LOAD; VIRUS REPLICATION;

ADULT; AFRICAN AMERICANS; ANTIGENS, CD14; BASE SEQUENCE; FEMALE; GENE EXPRESSION; HEME OXYGENASE-1; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOPHENOTYPING; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MONOCYTES; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; VIRAL LOAD;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84859885581     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2011.76     Document Type: Article

References (36)

1. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E et al. Directly measured kinetics of circulating T lymphocytes in normal and hiv-1-infected humans. Nat Med 1999; 5: 83-89. (Pubitemid 29051003)
2. Hazenberg MD, Stuart JW, Otto SA, Borleffs JC, Boucher CA, de Boer RJ et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000; 95: 249-255. (Pubitemid 30017249)
3. Kinoshita S, Su L, Amano M, Timmerman LA, Kaneshima H, Nolan GP. The T cell activation factor nf-atc positively regulates HIV-1 replication and gene expression in T cells. Immunity 1997; 6: 235-244. (Pubitemid 27148590)
4. Matsuyama T, Kobayashi N, Yamamoto N. Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS 1991; 5: 1405.
5. Poli G, FAUCI AS. The effect of cytokines and pharmacologic agents on chronic HIV infection. AIDS Res Hum Retroviruses 1992; 8: 191-197.
6. Haase AT. Early events in sexual transmission of HIV and SIV and opportunities for interventions. Annu Rev Med 2010; 62: 127-139.
7. Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, Narva?ez AB et al. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 2004; 104: 942-947. (Pubitemid 39038012)
8. Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E, Lampiris H et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virusinfected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187: 1534-1543. (Pubitemid 36578959)
9. Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179: 859-870. (Pubitemid 29159331)
10. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12: 1365-1371. (Pubitemid 44924494)
11. Baroncelli S, Galluzzo CM, Pirillo MF, Mancini MG, Weimer LE, Andreotti M et al. Microbial translocation is associated with residual viral replication in heart-treated HIV+ subjects with <50copies/ml HIV-1 RNA. J Clin Virol 2009; 46: 367-370.
12. Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203: 780-790.
13. Cassol E, Malfeld S, Mahasha P, van der Merwe S, Cassol S, Seebregts C et al. Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy. J Infect Dis 2010; 202: 723-733.
14. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006; 86: 583-650.
15. Burt TD, Seu L, Mold JE, Kappas A, McCune JM. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol 2010; 185: 5279-5288.
16. Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004; 37: 1097-1104. (Pubitemid 39296737)
17. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000; 66: 187-195. (Pubitemid 30481482)
18. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW et al. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 2002; 111: 1-8.
19. Ono K, Mannami T, Iwai N. Association of a promoter variant of the heme oxygenase-1 gene with hypertension in women. J Hypertens 2003; 21: 1497-1503. (Pubitemid 36994128)
20. Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, Kobayashi S et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 2003; 102: 1619-1621. (Pubitemid 37022551)
21. Taha H, Skrzypek K, Guevara I, Nigisch A, Mustafa S, Grochot-Przeczek A et al. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol 2010; 30: 1634-1641.
22. He Z, Hu Y, Feng L, Lu Y, Bao D, Xi Y et al. Association between HMOX-1 genotype and cardiac function during exercise. Appl Physiol Nutr Metab 2008; 33: 450-460.
23. Levere RD, Staudinger R, Loewy G, Kappas A, Shibahara S, Abraham NG. Elevated levels of heme oxygenase-1 activity and mRNA in peripheral blood adherent cells of acquired immunodeficiency syndrome patients. Am J Hematol 1993; 43: 19-23. (Pubitemid 23134577)
24. Hiki N, Berger D, Prigl C, Boelke E, Wiedeck H, Seidelmann M et al. Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria. Infect Immun 1998; 66: 1135-1141. (Pubitemid 28101157)
25. Bazil V, Strominger JL. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol 1991; 147: 1567-1574.
26. Chauveau C, Rémy S, Royer PJ, Hill M, Tanguy-Royer S, Hubert FX et al. Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood 2005; 106: 1694-1702.
27. Locher C, Vanham G, Kestens L, Kruger M, Ceuppens JL, Vingerhoets J et al. Expression patterns of fc gamma receptors, HLA-DR and selected adhesion molecules on monocytes from normal and HIV-infected individuals. Clin Exp Immunol 1994; 98: 115-122.
28. Thieblemont N, Weiss L, Sadeghi HM, Estcourt C, Haeffner-Cavaillon N. cd14lowcd16high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection. Eur J Immunol 1995; 25: 3418-3424.
29. Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS. Unique monocyte subset in patients with AIDS dementia. Lancet 1997; 349: 692-695. (Pubitemid 27107748)
30. Herbert A, Rich A. The biology of left-handed Z-DNA. J Biol Chem 1996; 271: 11595.
31. Ashino T, Yamanaka R, Yamamoto M, Shimokawa H, Sekikawa K, Iwakura Y et al. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. Mol Immunol 2008; 45: 2106-2115. (Pubitemid 351226260)
32. Brunt KR, Fenrich KK, Kiani G, Tse MY, Pang SC, Ward CA et al. Protection of human vascular smooth muscle cells from h2o2-induced apoptosis through functional codependence between HO-1 and AKT. Arterioscler Thromb Vasc Biol 2006; 26: 2027-202.
33. Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M et al. Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor bach1. Cancer Sci 2010; 101: 1409-1416.
34. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ 2001; 79: 704-712. (Pubitemid 32776838)
35. Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C et al. Genomewide detection and characterization of positive selection in human populations. Nature 2007; 449: 913-918.
36. Bharucha AE, Kulkarni A, Choi KM, Camilleri M, Lempke M, Brunn GJ et al. First-inhuman study demonstrating pharmacological activation of heme oxygenase-1 in humans. Clin Pharmacol Ther 2010; 87: 187-190.