Allosteric modulation of the dopamine D 2 Receptor by Pro-Leu-Gly-NH 2 peptidomimetics constrained in either a Polyproline II Helix or a type II β-turn conformation

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 2043-2051

  Raghavan, Bhooma ^a   Skoblenick, Kevin J ^b   Bhagwanth, Swapna ^a   Argintaru, Niran ^b   Mishra, Ram K ^b   Johnson, Rodney L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

(3' BETA,6' ALPHA,8'A ALPHA) 1 [2 PYRROLIDINYLCARBONYL] 5' OXOSPIRO[PYRROLIDINE 2,6' THIAZOLIDINO[3,2 A]PIPERIDINE] 3' CARBOXAMIDE; (3'ALPHA,6'ALPHA,8'A BETA) 1 [2 PYRROLIDINYLCARBONYL] 5' OXOSPIRO[PYRROLIDINE 2,6' THIAZOLIDINO[3,2 A]PIPERIDINE] 3' CARBOXAMIDE; (3'BETA,6'ALPHA,8'A BETA) 1 [2 PYRROLIDINYLCARBONYL] 5' OXOSPIRO[PYRROLIDINE 2,6' THIAZOLIDINO[3,2 A]PIPERIDINE] 3' CARBOXAMIDE; DOPAMINE 2 RECEPTOR; PEPTIDOMIMETIC AGENT; PROLYLLEUCYLGLYCINAMIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BETA TURN; CHIRALITY; COW; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN;

ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; CATTLE; CORPUS STRIATUM; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS, 2-RING; MOLECULAR MIMICRY; MSH RELEASE-INHIBITING HORMONE; OLIGOPEPTIDES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, DOPAMINE D2; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 64549087984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801575w     Document Type: Article

References (15)

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