Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P 3-sparing S1P 1 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3083-3088

  Asano, Masayoshi ^a   Nakamura, Tsuyoshi ^a   Sekiguchi, Yukiko ^a   Mizuno, Yumiko ^a   Yamaguchi, Takahiro ^a   Tamaki, Kazuhiko ^a   Shimozato, Takaichi ^a   Doi Komuro, Hiromi ^a   Kagari, Takashi ^a   Tomisato, Wataru ^a   Inoue, Ryotaku ^a   Yuita, Hiroshi ^a   Oguchi Oshima, Keiko ^a   Kaneko, Reina ^a   Nara, Futoshi ^a   Kawase, Yumi ^a   Masubuchi, Noriko ^a   Nakayama, Shintaro ^a   Koga, Tetsufumi ^a   Namba, Eiko ^a   Nasu, Hatsumi ^a   Nishi, Takahide ^a   more..

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Agonist; HvGR; Lymphocyte; S1P 1

Indexed keywords

1,3 THIAZOLYLTHIOPHENE DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; PYRIDINE DERIVATIVE; SPHINGOSINE 1 PHOSPHATE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROBACTERIACEAE; EXPERIMENTAL MONKEY; GRAFT VERSUS HOST REACTION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; HAPLORHINI; HUMANS; PYRIDINES; RATS; RECEPTORS, LYSOSPHINGOLIPID; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES;

ENTEROBACTERIACEAE; RATTUS;

EID: 84859872728     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.067     Document Type: Article

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