Metabolism, microflora effects, and genotoxicity in haloacetic acid-treated cultures of rat cecal microbiota

Toxicological Sciences

Volumn 60, Issue 2, 2001, Pages 232-241

  Nelson, G M ^a,c   Swank, A E ^a   Brooks, L R ^a   Bailey, K C ^b   George, S E ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Biotransformation; Disinfection by products; Enzymes; Intestinal flora; Mutagenicity; Salmonella microsuspension assay

Indexed keywords

ACETIC ACID DERIVATIVE; AZO REDUCTASE; BACTERIAL ENZYME; BETA GALACTOSIDASE; BETA GLUCOSIDASE; BETA GLUCURONIDASE; BROMOACETIC ACID; CARCINOGEN; CHLOROACETIC ACID; DRINKING WATER; HALOACETIC ACID; MUTAGENIC AGENT; NITROREDUCTASE; TRICHLOROACETIC ACID; UNCLASSIFIED DRUG;

ANAEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; BACTERIUM CULTURE; BIOASSAY; BIOTRANSFORMATION; CECUM; CONTROLLED STUDY; CULTURE MEDIUM; DISINFECTION; ENTEROCOCCUS; ENZYME ACTIVITY; ENZYME ASSAY; EXPOSURE; GENOTOXICITY; GROWTH CURVE; HOMOGENATE; INOCULATION; INTESTINE FLORA; LIVER CARCINOGENESIS; METABOLISM; MICROFLORA; MUTAGENICITY; NONHUMAN; RAT; SALMONELLA; TEMPERATURE; WATER TREATMENT;

ACETIC ACIDS; ANIMALS; BACTEROIDES; CECUM; DISINFECTION; DNA, BACTERIAL; MALE; MICROSOMES, LIVER; MUTAGENICITY TESTS; MUTAGENS; RATS; SALMONELLA TYPHIMURIUM; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; BACTERIA (MICROORGANISMS); ENTEROCOCCUS; MICROBIOTA; RODENTIA; SALMONELLA;

EID: 0035065837     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.2.232     Document Type: Article

References (25)

1. Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test: Activation of flavonol glycosides by mixed glycosides from rat cecal bacteria and other sources
2. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
3. Possible errors in assay for β-glycosidase activity
4. Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens
5. Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with Aroclor 1254
6. The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat
7. The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse
8. Cytotoxicity and effect on mutagenicity of buffers in a microsuspension assay
9. Dichloroacetic acid and related compounds: Induction of prophage in E.coli and mutagenicity and mutation spectra in Salmonella TA100
10. In vivo genotoxicity of dichloroacetic acid: Evaluation with the mouse peripheral blood micronucleus assay and the single cell gel assay
11. Role of the intestinal microbiota in the activation of the promutagen 2,6-dinitrotoluene to mutagenic urine metabolites and comparison of GI enzyme activities in male Fischer 344 rats
12. The disinfection by-products dichloro-, dibromo-, and bromochloroacetic acid impact intestinal microflora and metabolism in Fischer 344 rats upon exposure in drinking water
13. Comparative genotoxicity of halogenated acetic acids found in drinking water
14. In situ bacterial metabolism and colon mutagens
15. Genotoxic effects of by-products of the chlorination of drinking water
16. Intestinal bacteria and the hydrolysis of glycosidic bonds
17. Drinking water mutagenicity and gastrointestinal and urinary tract cancers: An ecological study in Finland
18. Tumor induction in germ-free rats with methylazoxymethanol (MAM) and synthetic MAM acetate
19. Formation of dichloroacetic acid by rat and mouse gut microflora, an in vitro study
20. Chlorination, chlorination by-products, and cancer: A meta-analysis
21. Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice
22. The ecology of the human intestine and its consequences for overgrowth by pathogens such as Clostridium difficile
23. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice