Synthesis and characterization of pyruvate-isoniazid analogs and their copper complexes as potential ICL inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3172-3176

  Shingnapurkar, Dipti ^a   Dandawate, Prasad ^a   Anson, Christopher E ^b   Powell, Annie K ^b   Afrasiabi, Zahra ^c   Sinn, Ekkehard ^c   Pandit, Shital ^e   Venkateswara Swamy, K ^e   Franzblau, Scott ^d   Padhye, Subhash ^a  

^a UNIVERSITY OF PUNE   (India)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e DR D Y PATIL BIOTECHNOLOGY AND BIOINFORMATICS INSTITUTE   (India)

Author keywords

Copper complex; Isocitrate lyase; Persistent mycobacteria; Pyruvic acid

Indexed keywords

COPPER COMPLEX; ENZYME INHIBITOR; GLYOXYLIC ACID; ISOCITRATE LYASE; ISONIAZID DERIVATIVE; PYRUVIC ACID; TUBERCULOSTATIC AGENT;

ANAEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; COPPER; ENZYME INHIBITORS; HUMANS; ISOCITRATE LYASE; ISONIAZID; MYCOBACTERIUM TUBERCULOSIS; PYRUVATES;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84859855723     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.047     Document Type: Article

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