Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6066-6069

  Lainé, Dramane I ^a   Xie, Haibo ^a   Buffet, Noémie ^a   Foley, James J ^a   Buckley, Peter ^a   Webb, Edward F ^a   Widdowson, Katherine L ^a   Palovich, Michael R ^a   Belmonte, Kristen E ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Ammonium; Antagonists; Muscarinic; Quaternary; Salts

Indexed keywords

8 AZONIABICYCLO[3.2.1]OCTANE CARBAMATE DERIVATIVE; BICYCLO COMPOUND; CARBAMIC ACID DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRONCHODILATOR AGENTS; CARBAMATES; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, MUSCARINIC; TROPANES;

EID: 35148894030     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.071     Document Type: Article

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