Agouti revisited: Transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Albrecht, Elke ^a   Komolka, Katrin ^a   Kuzinski, Judith ^a   Maak, Steffen ^a  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI PROTEIN; AGOUTI PROTEIN ANTIBODY; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASIP GENE; BODY FAT; BREED DIFFERENCE; CELL TYPE; CONTROLLED STUDY; COW; CYTOSOL; DEVELOPMENTAL GENE; GENE INSERTION; GENE LOCUS; GENE STRUCTURE; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR FAT; LIVER; LUNG PARENCHYMA; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; TRANSCRIPTION REGULATION; TRANSPOSON; UPREGULATION;

ADIPOSE TISSUE; AGOUTI SIGNALING PROTEIN; ANIMALS; CATTLE; EXONS; GENE EXPRESSION REGULATION; GENE ORDER; GENETIC LOCI; PROTEIN TRANSPORT; RECEPTORS, MELANOCORTIN; RNA, MESSENGER; SKIN; TRANSCRIPTION, GENETIC;

AGOUTI; ANIMALIA; BOS; BOVINAE; MAMMALIA;

EID: 84859836845     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035282     Document Type: Article

References (60)

1. Bultman SJ, Russell LB, Gutierrez-Espeleta GA, Woychik RP, (1991) Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse. Proc Natl Acad Sci U S A 88: 8062-8066.
2. Claycombe KJ, Xue BZ, Mynatt RL, Zemel MB, Moustaid-Moussa N, (2000) Regulation of leptin by agouti. Physiol Genomics 2: 101-105.
3. Lu D, Willard D, Patel IR, Kadwell S, Overton L, et al. (1994) Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371: 799-802.
4. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, et al. (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 51: 287-317.
5. Hiragaki T, Inoue-Murayama M, Miwa M, Fujiwara A, Mizutani M, et al. (2008) Recessive black is allelic to the yellow plumage locus in Japanese quail and associated with a frameshift deletion in the ASIP gene. Genetics 178: 771-775.
6. Girardot M, Martin J, Guibert S, Leveziel H, Julien R, et al. (2005) Widespread expression of the bovine Agouti gene results from at least three alternative promoters. Pigment Cell Res 18: 34-41.
7. Michaud EJ, Bultman SJ, Stubbs LJ, Woychik RP, (1993) The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein. Genes Dev 7: 1203-1213.
8. Yen TT, Gill AM, Frigeri LG, Barsh GS, Wolff GL, (1994) Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J 8: 479-488.
9. Duhl DM, Vrieling H, Miller KA, Wolff GL, Barsh GS, (1994) Neomorphic agouti mutations in obese yellow mice. Nat Genet 8: 59-65.
10. Kwon HY, Bultman SJ, Loffler C, Chen WJ, Furdon PJ, et al. (1994) Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc Natl Acad Sci U S A 91: 9760-9764.
11. Sumida T, Hino N, Kawachi H, Matsui T, Yano H, (2004) Expression of agouti gene in bovine adipocytes. Animal Science Journal 75: 49-51.
12. Girardot M, Guibert S, Laforet M-P, Gallard Y, Larroque H, et al. (2006) The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene. Pigment Cell Res 19: 346-355.
13. Graphodatskaya D, Joerg H, Asia-Coakwell M, Janett F, Stranzinger G, (2006) Expression and function of agouti signaling protein in cattle. Animal Science Journal 77: 33-41.
14. Yabuuchi M, Bando K, Hiramatsu M, Takahashi S, Takeuchi S, (2010) Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens. The Journal of Poultry Science 47: 176-182.
15. Fontanesi L, Forestier L, Allain D, Scotti E, Beretti F, et al. (2009) Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour. Genomics 95: 166-175.
16. Xue B, Moustaid N, Wilkison WO, Zemel MB, (1998) The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB J 12: 1391-1396.
17. Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, et al. (1997) Effects of recombinant agouti-signaling protein on melanocortin action. Mol Endocrinol 11: 274-280.
18. Michaud EJ, Mynatt RL, Miltenberger RJ, Klebig ML, Wilkinson JE, et al. (1997) Role of the agouti gene in obesity. J Endocrinol 155: 207-209.
19. Smith SR, Gawronska-Kozak B, Janderova L, Nguyen T, Murrell A, et al. (2003) Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes. Diabetes 52: 2914-2922.
20. Hoch M, Eberle AN, Wagner U, Bussmann C, Peters T, et al. (2007) Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients. Obesity (Silver Spring) 15: 40-49.
21. Mynatt RL, Stephens JM, (2001) Agouti regulates adipocyte transcription factors. Am J Physiol Cell Physiol 280: C954-C961.
22. Albrecht E, Gotoh T, Ebara F, Xu JX, Viergutz T, et al. (2011) Cellular conditions for intramuscular fat deposition in Japanese Black and Holstein steers. Meat Sci 89: 13-20.
23. Gotoh T, Albrecht E, Teuscher F, Kawabata K, Sakashita K, et al. (2009) Differences in muscle and fat accretion in Japanese Black and European cattle. Meat Sci.
24. Hiller B, Herdmann A, Nuernberg K, (2011) Dietary n-3 fatty acids significantly suppress lipogenesis in bovine muscle and adipose tissue: a functional genomics approach. Lipids 46: 557-567.
25. Pfaffl MW, Horgan GW, Dempfle L, (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36.
26. Klungland H, Vage DI, Gomez-Raya L, Adalsteinsson S, Lien S, (1995) The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. Mamm Genome 6: 636-639.
27. Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, et al. (2009) A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol 10: R42.
28. Zhang CL, Wang YH, Lei CZ, Fang XT, Chen H, (2011) The polymorphisms of bovine melanocortin-3 receptor pseudogene. Res Vet Sci 90: 241-244.
29. Amweg AN, Paredes A, Salvetti NR, Lara HE, Ortega HH, (2011) Expression of melanocortin receptors mRNA, and direct effects of ACTH on steroid secretion in the bovine ovary. Theriogenology 75: 628-637.
30. Klebig ML, Wilkinson JE, Geisler JG, Woychik RP, (1995) Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A 92: 4728-4732.
31. Fontanesi L, Scotti E, Colombo M, Beretti F, Forestier L, (2010) A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus). BMC Genet 11: 59.
32. Wilson BD, Ollmann MM, Kang L, Stoffel M, Bell GI, et al. (1995) Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet 4: 223-230.
33. Matsunaga N, Virador V, Santis C, Vieira WD, Furumura M, et al. (2000) In situ localization of agouti signal protein in murine skin using immunohistochemistry with an ASP-specific antibody. Biochem Biophys Res Commun 270: 176-182.
34. Bultman SJ, Michaud EJ, Woychik RP, (1992) Molecular characterization of the mouse agouti locus. Cell 71: 1195-1204.
35. Vrieling H, Duhl DM, Millar SE, Miller KA, Barsh GS, (1994) Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91: 5667-5671.
36. Leeb T, Doppe A, Kriegesmann B, Brenig B, (2000) Genomic structure and nucleotide polymorphisms of the porcine agouti signalling protein gene (ASIP). Anim Genet 31: 335-336.
37. Kanetsky PA, Swoyer J, Panossian S, Holmes R, Guerry D, et al. (2002) A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am J Hum Genet 70: 770-775.
38. Drogemuller C, Giese A, Martins-Wess F, Wiedemann S, Andersson L, et al. (2006) The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence. Mamm Genome 17: 58-66.
39. Norris BJ, Whan VA, (2008) A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep. Genome Res 18: 1282-1293.
40. Dreger DL, Schmutz SM, (2011) A SINE Insertion Causes the Black-and-Tan and Saddle Tan Phenotypes in Domestic Dogs. J Hered 102 (Suppl 1): S11-S18.
41. Jackson PJ, Douglas NR, Chai B, Binkley J, Sidow A, et al. (2006) Structural and molecular evolutionary analysis of Agouti and Agouti-related proteins. Chem Biol 13: 1297-1305.
42. Siracusa LD, (1994) The agouti gene: turned on to yellow. Trends Genet 10: 423-428.
43. Miltenberger RJ, Wakamatsu K, Ito S, Woychik RP, Russell LB, et al. (2002) Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus. Genetics 160: 659-674.
44. Gratten J, Pilkington JG, Brown EA, Beraldi D, Pemberton JM, et al. (2010) The genetic basis of recessive self-colour pattern in a wild sheep population. Heredity 104: 206-214.
45. Rieder S, Taourit S, Mariat D, Langlois B, Guerin G, (2001) Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mamm Genome 12: 450-455.
46. Anno S, Abe T, Yamamoto T, (2008) Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects. Int J Biol Sci 4: 81-86.
47. Shi KR, Wang AG, Yuan XF, Deng XM, Li N, (2006) Analysis of the MC1R, KIT and ASIP loci in Chinese and European pigs. Anim Genet 37: 300-302.
48. Badaoui B, D'Andrea M, Pilla F, Capote J, Zidi A, et al. (2011) Polymorphism of the goat agouti signaling protein gene and its relationship with coat color in italian and Spanish breeds. Biochem Genet 49: 523-532.
49. Royo LJ, Alvarez I, Fernandez I, Arranz JJ, Gomez E, et al. (2005) The coding sequence of the ASIP gene is identical in nine wild-type coloured cattle breeds. J Anim Breed Genet 122: 357-360.
50. Adelson DL, Raison JM, Edgar RC, (2009) Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome. Proc Natl Acad Sci U S A 106: 12855-12860.
51. Bultman SJ, Klebig ML, Michaud EJ, Sweet HO, Davisson MT, et al. (1994) Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8: 481-490.
52. Fontanesi L, Beretti F, Riggio V, Gomez GE, Dall'Olio S, et al. (2009) Copy number variation and missense mutations of the agouti signaling protein (ASIP) gene in goat breeds with different coat colors. Cytogenet Genome Res 126: 333-347.
53. Fadista J, Thomsen B, Holm LE, Bendixen C, (2010) Copy number variation in the bovine genome. BMC Genomics 11: 284.
54. Bae JS, Cheong HS, Kim LH, NamGung S, Park TJ, et al. (2010) Identification of copy number variations and common deletion polymorphisms in cattle. BMC Genomics 11: 232.
55. Liu GE, Hou Y, Zhu B, Cardone MF, Jiang L, et al. (2010) Analysis of copy number variations among diverse cattle breeds. Genome Res 20: 693-703.
56. Kijas JW, Barendse W, Barris W, Harrison B, McCulloch R, et al. (2011) Analysis of copy number variants in the cattle genome. Gene 482: 73-77.
57. Chagnon YC, Chen WJ, Perusse L, Chagnon M, Nadeau A, et al. (1997) Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Mol Med 3: 663-673.
58. Liakos P, Chambaz EM, Feige JJ, Defaye G, (1998) Expression of ACTH receptors (MC2-R and MC5-R) in the glomerulosa and the fasciculata-reticularis zones of bovine adrenal cortex. Endocr Res 24: 427-432.
59. Liakos P, Chambaz EM, Feige JJ, Defaye G, (2000) Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex. Mol Cell Endocrinol 159: 99-107.
60. Doghman M, Delagrange P, Blondet A, Berthelon MC, Durand P, et al. (2004) Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control. Endocrinology 145: 541-547.