Serpin protease inhibitors in plant biology

Physiologia Plantarum

Volumn 145, Issue 1, 2012, Pages 95-102

  Fluhr, Robert ^a   Lampl, Nardy ^a   Roberts, Thomas H ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS PROTEIN; CASPASE; METACASPASE 9, ARABIDOPSIS; SERINE PROTEINASE INHIBITOR; SERPIN1 PROTEIN, ARABIDOPSIS;

ARABIDOPSIS; CELL DEATH; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETIC VARIABILITY; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; REVIEW;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CASPASES; CATALYTIC DOMAIN; CELL DEATH; GENETIC VARIATION; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SERINE PROTEINASE INHIBITORS; SERPINS; STRESS, PHYSIOLOGICAL; SUBSTRATE SPECIFICITY;

ANIMALIA; ARABIDOPSIS; ARABIDOPSIS THALIANA; MAMMALIA;

EID: 84859835280     PISSN: 00319317     EISSN: 13993054     Source Type: Journal    
DOI: 10.1111/j.1399-3054.2011.01540.x     Document Type: Review

References (49)

1. Ahn JW, Atwell BJ, Roberts TH (2009) Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis. BMC Plant Biol 9: 52, DOI: 10.1186/1471-2229-9-52
2. Alvarez-Alfageme F, Maharramov J, Carrillo L, Vandenabeele S, Vercammen D, Van Breusegem F, Smagghe G (2011) Potential use of a serpin from Arabidopsis for pest control. PLoS One 6: e20278
3. Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, Tamai M, Hanada K (1982) L-trans- Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J 201: 189-198
4. Beers EP, Jones AM, Dickerman AW (2004) The S8 serine, C1A cysteine and Al aspartic protease families in Arabidopsis. Phytochemistry 65: 43-58
5. Beinrohr L, Harmat V, Dobo J, Lorincz Z, Gal P, Zavodszky P (2007) C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. J Biol Chem 282: 21100-21109
6. Bird CH, Blink EJ, Hirst CE, Buzza MS, Steele PM, Sun J, Jans DA, Bird PI (2001) Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol Cell Biol 21: 5396-5407
7. Carrell RW, Owen MC (1985) Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature 317: 730-732
8. Carrell R, Travis J (1985) Alpha1-antitrypsin and the serpins: variation and countervariation. Trends Biochem Sci 10: 20-24
9. Chen HJ, Huang DJ, Hou WC, Liu JS, Lin YH (2006) Molecular cloning and characterization of a granulin-containing cysteine protease SPCP3 from sweet potato (Ipomoea batatas) senescent leaves. J Plant Physiol 163: 863-876
10. Coupe SA, Sinclair BK, Watson LM, Heyes JA, Eason JR (2003) Identification of dehydration-responsive cysteine proteases during post-harvest senescence of broccoli florets. J Exp Bot 54: 1045-1056
11. Crooks GE, Hon G, Chandonia JM, Brenner SE (2004) WebLogo: a sequence logo generator. Genome Res 14: 1188-1190
12. Dahl SW, Rasmussen SK, Hejgaard J (1996a) Heterologous expression of three plant serpins with distinct inhibitory specificities. J Biol Chem 271: 25083-25088
13. Dahl SW, Rasmussen SK, Petersen LC, Hejgaard J (1996b) Inhibition of coagulation factors by recombinant barley serpin BSZx. FEBS Lett 394: 165-168
14. Dementiev A, Dobo J, Gettins PG (2006) Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase. J Biol Chem 281: 3452-3457
15. Duncan RC, Wijeyewickrema LC, Pike RN (2008) The initiating proteases of the complement system: controlling the cleavage. Biochimie 90: 387-395
16. Harrak H, Azelmat S, Baker EN, Tabaeizadeh Z (2001) Isolation and characterization of a gene encoding a drought-induced cysteine protease in tomato (Lycopersicon esculentum). Genome 44: 368-374
17. Hayashi Y, Yamada K, Shimada T, Matsushima R, Nishizawa NK, Nishimura M, Hara-Nishimura I (2001) A proteinase-storing body that prepares for cell death or stresses in the epidermal cells of Arabidopsis. Plant Cell Physiol 42: 894-899
18. Hejgaard J (2001) Inhibitory serpins from rye grain with glutamine as P-1 and P-2 residues in the reactive center. FEBS Lett 488: 149-153
19. Hejgaard J (2005) Inhibitory plant serpins with a sequence of three glutamine residues in the reactive center. Biol Chem 386: 1319-1323
20. Hejgaard J, Hauge S (2002) Serpins of oat (Avena sativa) grain with distinct reactive centres and inhibitory specificity. Physiol Plant 116: 155-163
21. Hejgaard J, Roberts TH (2007) Plant serpins. In: Silverman GA, Lomas DA (eds) Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. World Scientific, New Jersey, pp 279-300
22. Hirst CE, Buzza MS, Bird CH, Warren HS, Cameron PU, Zhang M, Ashton-Rickardt PG, Bird PI (2003) The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815
23. Huntington JA, Read RJ, Carrell RW (2000) Structure of a serpin-protease complex shows inhibition by deformation. Nature 407: 923-926
24. Irving JA, Pike RN, Lesk AM, Whisstock JC (2000) Phylogeny of the serpin superfamily. Implications of amino acid conservation for structure and function. Genome Res 10: 1845-1864
25. Johnson DJ, Li W, Adams TE, Huntington JA (2006) Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. EMBO J 25: 2029-2037
26. Jongsma MA, Bolter C (1997) The adaption of insects to plant protease inhibitors. J Insect Physiol 43: 885-895
27. Kikuchi Y, Saika H, Yuasa K, Nagahama M, Tsuji A (2008) Isolation and biochemical characterization of two forms of RD21 from cotyledons of daikon radish (Raphanus sativus). J Biochem (Tokyo) 144: 789-798
28. Koizumi M, Yamaguchishinozaki K, Tsuji H, Shinozaki K (1993) Structure and expression of 2 genes that encode distinct drought-inducible cysteine proteinases in Arabidopsis thaliana. Gene 129: 175-182
29. Lampl N, Budai-Hadrian O, Davydov O, Joss TV, Harrop SJ, Curmi PM, Roberts TH, Fluhr R (2010) Arabidopsis AtSerpin1: crystal structure and in vivo interaction with its target protease responsive to desiccation-21 (RD21). J Biol Chem 285: 13550-13560
30. Law RHP, Zhang QW, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC (2006) An overview of the serpin superfamily. Genome Biol 7: 216
31. Li W, Johnson DJ, Esmon CT, Huntington JA (2004) Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol 11: 857-862.
32. Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Bromme D, Silverman GA (2007) An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell 130: 1108-1119
33. Matsushima R, Hayashi Y, Yamada K, Shimada T, Nishimura M, Hara-Nishimura I (2003) The ER body, a novel endoplasmic reticulum-derived structure in Arabidopsis. Plant Cell Physiol 44: 661-666
34. Ogasawara K, Yamada K, Christeller JT, Kondo M, Hatsugai N, Hara-Nishimura I, Nishimura M (2009) Constitutive and inducible ER bodies of Arabidopsis thaliana accumulate distinct beta-glucosidases. Plant Cell Physiol 50: 480-488
35. Ondzighi CA, Christopher DA, Cho EJ, Chang SC, Staehelin LA (2008) Arabidopsis protein disulfide isomerase-5 inhibits cysteine proteases during trafficking to vacuoles before programmed cell death of the endothelium in developing seeds. Plant Cell 20: 2205-2220
36. Ostergaard H, Rasmussen SK, Roberts TH, Hejgaard J (2000) Inhibitory serpins from wheat grain with reactive centers resembling glutamine-rich repeats of prolamin storage proteins - cloning and characterization of five major molecular forms. J Biol Chem 275: 33272-33279
37. Ostergaard O, Finnie C, Laugesen S, Roepstorff P, Svensson B (2004) Proteome analysis of barley seeds: identification of major proteins from two-dimensional gels (pl 4-7). Proteomics 4: 2437-2447
38. Roberts TH, Hejgaard J (2008) Serpins in plants and green algae. Funct Integr Genomics 8: 1-27
39. Silverman GA, Whisstock JC, Askew DJ, Pak SC, Luke CJ, Cataltepe S, Irving JA, Bird PI (2004) Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis. Cell Mol Life Sci 61: 301-325
40. Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI (2010) Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem 285: 24299-24305
41. van der Hoorn RA (2008) Plant proteases: from phenotypes to molecular mechanisms. Annu Rev Plant Biol 59: 191-223
42. Vercammen D, van de Cotte B, De Jaeger G, Eeckhout D, Casteels P, Vandepoele K, Vandenberghe I, Van Beeumen J, Inze D, Van Breusegem F (2004) Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine. J Biol Chem 279: 45329-45336
43. Vercammen D, Belenghi B, van de Cotte B, Beunens T, Gavigan JA, De Rycke R, Brackenier A, Inze D, Harris JL, Van Breusegem F (2006) Serpin1 of Arabidopsis thaliana is a suicide inhibitor for Metacaspase 9. J Mol Biol 364: 625-636
44. Watanabe N, Lam E (2005) Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. J Biol Chem 280: 14691-14699
45. Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA (2010) Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem 285: 24307-24312
46. Yamada K, Matsushima R, Nishimura M, Hara-Nishimura I (2001) A slow maturation of a cysteine protease with a granulin domain in the vacuoles of senescing Arabidopsis leaves. Plant Physiol 127: 1626-1634
47. Ye S, Cech AL, Belmares R, Bergstrom RC, Tong YR, Corey DR, Kanost MR, Goldsmith EJ (2001) The structure of a Michaelis serpin-protease complex. Nat Struct Biol 8: 979-983
48. Yoo BC, Aoki K, Xiang Y, Campbell LR, Hull RJ, Xoconostle-Cazares B, Monzer J, Lee JY, Ullman DE, Lucas WJ (2000) Characterization of Cucurbita maxima phloem serpin-1 (CmPS-1) - a developmentally regulated elastase inhibitor. J Biol Chem 275: 35122-35128
49. Zimmermann P, Hirsch-Hoffmann M, Hennig L, Gruissem W (2004) GENEVESTIGATOR. Arabidopsis microarray database and analysis toolbox. Plant Physiol 136: 2621-2632