Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-d- ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3058-3065

  Tuncbilek, Meral ^a   Bilget Guven, Ebru ^b   Onder, Tugce ^a   Cetin Atalay, Rengul ^b  

^a ANKARA UNIVERSITY   (Turkey)

^b BILKENT UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 PIPERAZINE 1 YL) 9 (BETA DEXTRO RIBOFURANOSYL); ANTINEOPLASTIC AGENT; PURINE NUCLEOSIDE DERIVATIVE; RETINOBLASTOMA PROTEIN; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL ACTIVITY; CELL DEATH; CELL STRAIN HEPG2; COLON CARCINOMA; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HEPATOMA CELL; IC 50; LIVER CANCER; PROTEIN PHOSPHORYLATION; SENESCENCE;

ADENOSINE; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELL DEATH; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PURINE NUCLEOSIDES; RETINOBLASTOMA PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859806562     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3001532     Document Type: Article

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