TFPI-dependent activities of Protein S

Thrombosis Research

Volumn 129, Issue SUPPL. 2, 2012, Pages

  Peraramelli, Sameera ^a   Rosing, Jan ^a   Hackeng, Tilman M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

anticoagulants; APC; protein S; TFPI

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8A; PROTEIN S; TISSUE FACTOR PATHWAY INHIBITOR;

ANTICOAGULATION; BLOOD CLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; THROMBOSIS;

EID: 84859799365     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.02.024     Document Type: Article

References (35)

1. Hackeng TM, van 't Veer C, Meijers JC, Bouma BN. Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa. J Biol Chem Aug 19 1994;269(33):21051-8. (Pubitemid 24266474)
2. Vantveer C, Hackeng TM, Biesbroeck D, Sixma JJ, Bouma BN. Increased Prothrombin Activation in Protein S-Deficient Plasma under Flow Conditions on Endothelial-Cell Matrix - an Independent Anticoagulant Function of Protein-S in Plasma. Blood Apr 1 1995;85(7):1815-21.
3. Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem Feb 5 1993;268(4):2872-7. (Pubitemid 23057922)
4. Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci U S A Mar 29 1994;91(7):2728-32. (Pubitemid 24139421)
5. Mitchell CA, Kelemen SM, Salem HH. The anticoagulant properties of a modified form of protein S. Thromb Haemost Oct 31 1988;60(2):298-304.
6. Sere KM, Janssen MP,Willems GM, Tans G, Rosing J, Hackeng TM. Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry Jul 31 2001;40(30):8852-60. (Pubitemid 32709518)
7. Sere KM, Willems GM, Rosing J, Hackeng TM. Protein S multimers are generated in vitro and affect protein S structure-function analyses. Semin Hematol Jan 2006;43(1 Suppl. 1):S111-20. (Pubitemid 43150513)
8. SeréKM, Rosing J,Hackeng TM. Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications formaintenance of the hemostatic balance. Blood Dec 1 2004;104(12):3624-30. (Pubitemid 39564437)
9. Hackeng TM, Seré KM, Tans G, Rosing J. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci U S A Feb 28 2006;103(9):3106-11. (Pubitemid 43346432)
10. Girard TJ,Warren LA, NovotnyWF, Likert KM, Brown SG,Miletich JP, et al. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature Apr 6 1989;338(6215):518- 20. (Pubitemid 19107996)
11. Huang ZF, Wun TC, Broze GJ. Kinetics of Factor-Xa Inhibition by Tissue Factor Pathway Inhibitor. J Biol Chem Dec 25 1993;268(36):26950-5.
12. Ndonwi M, Broze Jr GJ. Protein S enhances the TFPI inhibition of factor Xa but not its inhibition of factor VIIa/tissue factor. J Thromb Haemost 2008;6:1044-6. (Pubitemid 351689932)
13. Ndonwi M, Tuley EA, Broze Jr GJ. The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition. Blood Aug 26 2010;116(8):1344-51.
14. Broze GJ,Warren LA,NovotnyWF,Higuchi DA, Girard JJ, Miletich JP. The Lipoprotein-Associated Coagulation Inhibitor That Inhibits the Factor-Vii-Tissue Factor Complex Also Inhibits Factor Xa - Insight into Its Possible Mechanism of Action. Blood Feb 1988;71(2):335-43.
15. Baugh RJ, Broze Jr GJ, Krishnaswamy S. Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor. J Biol Chem Feb 20 1998;273(8): 4378-86. (Pubitemid 28103174)
16. Sandset PM, Abildgaard U. Extrinsic pathway inhibitor-the key to feedback control of blood coagulation initiated by tissue thromboplastin. Haemostasis 1991;21(4):219-39.
17. Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze GJ. Plasma Antigen Levels of the Lipoprotein-Associated Coagulation Inhibitor in Patient Samples. Blood Jul 15 1991;78(2):387-93.
18. Mast AE, Broze Jr GJ. Physiological concentrations of tissue factor pathway inhibitor do not inhibit prothrombinase. Blood Mar 1 1996;87(5):1845-50. (Pubitemid 26068899)
19. Broze GJ, Girard TJ, Novotny WF. Regulation of Coagulation by a Multivalent Kunitz-Type Inhibitor. Biochemistry Aug 21 1990;29(33):7539-46. (Pubitemid 20279168)
20. Nicolaes GA, Thomassen MC, Tans G, Rosing J, Hemker HC. Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals. Blood Coagul Fibrinolysis Jan 1997;8(1):28-38. (Pubitemid 27156097)
21. Curvers J, ThomassenMC, Rimmer J,Hamulyak K, van derMeer J, Tans G, et al. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Thromb Haemost Jul 2002;88(1):5-11. (Pubitemid 34752259)
22. De Visser MCH, Vlieg AV, Tans G, Rosing J, Dahm AEA, Sandset PM, et al. Determinants of the APTT- and ETP-based APC sensitivity tests. J Thromb Haemost 2005 Jul;3(7):1488-94. (Pubitemid 41725208)
23. Huang ZF, Higuchi D, Lasky N, Broze Jr GJ. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood Aug 1 1997;90(3): 944-51. (Pubitemid 27314126)
24. Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernandez JA, et al. Generation and phenotypic analysis of protein S-deficientmice. Blood Sep 10 2009;114(11): 2307-14.
25. Hoffman M, Whinna HC, Monroe DM. Circulating tissue factor accumulates in thrombi, but not in hemostatic plugs. J Thromb Haemost Sep 2006;4(9): 2092-3. (Pubitemid 44226805)
26. Bajaj MS, Kuppuswamy MN, Saito H, Spitzer SG, Bajaj SP. Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis. Proc Natl Acad Sci U S A Nov 1990;87(22):8869-73. (Pubitemid 120007610)
27. Stern D, Brett J, Harris K, Nawroth P. Participation of endothelial cells in the protein C-protein S anticoagulant pathway: the synthesis and release of protein S. J Cell Biol May 1986;102(5):1971-8. (Pubitemid 16078781)
28. Burstyn-Cohen T, Heeb MJ, Lemke G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest Oct 2009;119(10): 2942-53.
29. Lindahl AK, Sandset PM, Abildgaard U. The present status of tissue factor pathway inhibitor. Blood Coagul Fibrinolysis Aug 1992;3(4):439-49.
30. Sandset PM, Abildgaard U, Larsen ML. Heparin induces release of extrinsic coagulation pathway inhibitor (EPI). Thromb Res Jun 15 1988;50(6):803-13.
31. Ariens RA, Alberio G, Moia M, Mannucci PM. Low levels of heparin-releasable tissue factor pathway inhibitor in young patients with thrombosis. Thromb Haemost Feb 1999;81(2):203-7. (Pubitemid 29078303)
32. Dahm AE, Sandset PM, Rosendaal FR. The association between protein S levels and anticoagulant activity of tissue factor pathway inhibitor type 1. J Thromb Haemost Feb 2008;6(2):393-5.
33. Castoldi E, Simioni P, Tormene D, Rosing J, Hackeng TM. Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma. J Thromb Haemost Feb 2010;8(2):294-300.
34. Castoldi E, Hackeng TM. Regulation of coagulation by protein S. Curr Opin Hematol Sep 2008;15(5):529-36.
35. Hackeng TM, Maurissen LFA, Castoldi E, Rosing J. Regulation of TFPI function by protein S. J Thromb Haemost 2009;7:165-8.