메뉴 건너뛰기




Volumn 8, Issue 1, 1997, Pages 28-38

Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals

Author keywords

APC resistance; factor V(Leiden); thrombin generation; thrombosis

Indexed keywords

ACTIVATED PROTEIN C; THROMBIN;

EID: 0030900138     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-199701000-00006     Document Type: Article
Times cited : (93)

References (42)
  • 1
    • 0027446268 scopus 로고
    • Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
    • Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1004-1008
    • Dahlbäck, B.1    Carlsson, M.2    Svensson, P.J.3
  • 2
    • 0027520285 scopus 로고
    • Venous thrombosis due to a poor anticoagulant response to activated protein C: Leiden Thrombophilia Study
    • Koster T, Rosendaal FR, De Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to a poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-1506.
    • (1993) Lancet , vol.342 , pp. 1503-1506
    • Koster, T.1    Rosendaal, F.R.2    De Ronde, H.3    Briët, E.4    Vandenbroucke, J.P.5    Bertina, R.M.6
  • 3
    • 0028326025 scopus 로고
    • The prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects
    • Halbmayer WM, Haushofer A, Schön R, Fischer M. The prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects. Blood Coag Fibrin 1995; 5: 51-57.
    • (1995) Blood Coag Fibrin , vol.5 , pp. 51-57
    • Halbmayer, W.M.1    Haushofer, A.2    Schön, R.3    Fischer, M.4
  • 4
    • 0027428481 scopus 로고
    • Anticoagulant protein C pathway defective in a majority of thrombophilic patients
    • Griffin JH, Evatt B, Wideman C, Fernandez JA. Anticoagulant protein C pathway defective in a majority of thrombophilic patients. Blood 1993; 82: 1989-1993.
    • (1993) Blood , vol.82 , pp. 1989-1993
    • Griffin, J.H.1    Evatt, B.2    Wideman, C.3    Fernandez, J.A.4
  • 5
    • 0028351510 scopus 로고
    • Frequency of a defective response to activated protein C in patients with a history of venous thrombosis
    • Cadroy Y, Sie P, Boneu B. Frequency of a defective response to activated protein C in patients with a history of venous thrombosis. Blood 1994; 83: 2008-2009.
    • (1994) Blood , vol.83 , pp. 2008-2009
    • Cadroy, Y.1    Sie, P.2    Boneu, B.3
  • 6
    • 0028098210 scopus 로고
    • Resistance to activated protein C as a basis for venous thrombosis
    • Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-522.
    • (1994) N Engl J Med , vol.330 , pp. 517-522
    • Svensson, P.J.1    Dahlbäck, B.2
  • 7
    • 0028314865 scopus 로고
    • Mutation in blood coagulation factor V associated with resistance to activated protein C
    • Bertina RM, Koeleman BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
    • (1994) Nature , vol.369 , pp. 64-67
    • Bertina, R.M.1    Koeleman, B.P.C.2    Koster, T.3
  • 8
    • 0028243401 scopus 로고
    • Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V
    • Voorberg J, Roelse J, Koopman R, et al. Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet 1994; 343: 1535-1536.
    • (1994) Lancet , vol.343 , pp. 1535-1536
    • Voorberg, J.1    Roelse, J.2    Koopman, R.3
  • 9
    • 0028352460 scopus 로고
    • Activated protein C resistance caused by Arg506Gln mutation in factor Va
    • Greengard JS, Sun X, Xu X, Fernandez JA, Griffin JH, Evatt B. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet 1994; 343: 1361-1362.
    • (1994) Lancet , vol.343 , pp. 1361-1362
    • Greengard, J.S.1    Sun, X.2    Xu, X.3    Fernandez, J.A.4    Griffin, J.H.5    Evatt, B.6
  • 11
    • 0028037137 scopus 로고
    • Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C
    • Zöller B, Svensson PJ, He X, Dahlbäck B. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 1994; 94: 2521-2524.
    • (1994) J Clin Invest , vol.94 , pp. 2521-2524
    • Zöller, B.1    Svensson, P.J.2    He, X.3    Dahlbäck, B.4
  • 12
    • 0028110027 scopus 로고
    • The mechanism of inactivation of human factor V and human factor Va by activated protein C
    • Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem 1994; 269: 31869-31880.
    • (1994) J Biol Chem , vol.269 , pp. 31869-31880
    • Kalafatis, M.1    Rand, M.D.2    Mann, K.G.3
  • 13
    • 0028939318 scopus 로고
    • Characterixation of the molecular detect in factor VR506Q
    • Kalafatis M, Bertina RM, Rand MR, Mann KG. Characterixation of the molecular detect in factor VR506Q. J Biol Chem 1995; 270: 4053-4057.
    • (1995) J Biol Chem , vol.270 , pp. 4053-4057
    • Kalafatis, M.1    Bertina, R.M.2    Rand, M.R.3    Mann, K.G.4
  • 14
    • 0029133654 scopus 로고
    • Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
    • Nicolaes GAF, Tans G, Thomassen MCLGD, et al. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 21158-21166.
    • (1995) J Biol Chem , vol.270 , pp. 21158-21166
    • Nicolaes, G.A.F.1    Tans, G.2    Thomassen, M.C.L.G.D.3
  • 15
    • 0028959158 scopus 로고
    • Inherited thrombophilia: Resistance to activated protein C as a pathogenic factor of venous thromboembolism
    • Dahlbäck B. Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism. Blood 1995; 85: 607-614.
    • (1995) Blood , vol.85 , pp. 607-614
    • Dahlbäck, B.1
  • 16
    • 0029162113 scopus 로고
    • Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives
    • Hellgren M, Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives. AmJ Obstet Gynecol 1995; 173: 210-213.
    • (1995) AmJ Obstet Gynecol , vol.173 , pp. 210-213
    • Hellgren, M.1    Svensson, P.J.2    Dahlbäck, B.3
  • 17
    • 0028291210 scopus 로고
    • Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis
    • Zöller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994; 343: 1536-1538.
    • (1994) Lancet , vol.343 , pp. 1536-1538
    • Zöller, B.1    Dahlbäck, B.2
  • 18
    • 0029000287 scopus 로고
    • A rapid screening method for the factor V Arg506- > Gln mutation
    • Gandrille S, Alhenc-Gelas M, Aiach M. A rapid screening method for the factor V Arg506- > Gln mutation. Blood Coag Fibrinol 1995; 6: 245-248.
    • (1995) Blood Coag Fibrinol , vol.6 , pp. 245-248
    • Gandrille, S.1    Alhenc-Gelas, M.2    Aiach, M.3
  • 19
    • 0022534734 scopus 로고
    • A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes
    • Hemker HC, Willems GM, Béguin S. A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. Thromb Hacmost 1986; 56: 9-17.
    • (1986) Thromb Hacmost , vol.56 , pp. 9-17
    • Hemker, H.C.1    Willems, G.M.2    Béguin, S.3
  • 20
    • 0028035075 scopus 로고
    • Analysis of thrombin generation in plasma
    • Kessels H, Willems G, Hemker HC. Analysis of thrombin generation in plasma. Comp Biol Med 1994; 24: 277-288.
    • (1994) Comp Biol Med , vol.24 , pp. 277-288
    • Kessels, H.1    Willems, G.2    Hemker, H.C.3
  • 21
    • 0028323644 scopus 로고
    • A new method based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma
    • Duchemin J, Pittet J-L, Tartary M, et al. A new method based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma. Thromb Haemostas 1994; 71: 331-338.
    • (1994) Thromb Haemostas , vol.71 , pp. 331-338
    • Duchemin, J.1    Pittet, J.-L.2    Tartary, M.3
  • 22
    • 0027377650 scopus 로고
    • Continuous registration of thrombin generation in plasma, its use for determination of the thrombin potential
    • Hemker HC, Wielders S, Kessels H, Béguin S. Continuous registration of thrombin generation in plasma, its use for determination of the thrombin potential. Thromb Haemost 1993; 70: 617-624.
    • (1993) Thromb Haemost , vol.70 , pp. 617-624
    • Hemker, H.C.1    Wielders, S.2    Kessels, H.3    Béguin, S.4
  • 23
    • 0029085314 scopus 로고
    • Thrombin generation in plasma: Its assessment via the endogenous thrombin potential
    • Hemker HC, Béguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 1995; 74: 134-138.
    • (1995) Thromb Haemost , vol.74 , pp. 134-138
    • Hemker, H.C.1    Béguin, S.2
  • 24
    • 0027442867 scopus 로고
    • Characterization of two forms of human factor Va with different cofactor activities
    • Rosing J, Bakker HM Thomassen MCLGD, Hemker HC, Tans G. Characterization of two forms of human factor Va with different cofactor activities. J Biol Chem 1993; 268: 21130-21136.
    • (1993) J Biol Chem , vol.268 , pp. 21130-21136
    • Rosing, J.1    Bakker, H.M.2    Thomassen, M.C.L.G.D.3    Hemker, H.C.4    Tans, G.5
  • 25
    • 50549164858 scopus 로고
    • A rapid and sensitive sub-micro phosphorus determination
    • Böttcher CJF, van Gent CM, Pries C. A rapid and sensitive sub-micro phosphorus determination. Anal Chim Acta 1961; 24: 203-207.
    • (1961) Anal Chim Acta , vol.24 , pp. 203-207
    • Böttcher, C.J.F.1    Van Gent, C.M.2    Pries, C.3
  • 26
    • 0021318997 scopus 로고
    • A functional assay of protein C in human plasma
    • Sala N, Owen WG, Collen D. A functional assay of protein C in human plasma. Blood 1984; 63: 671-675.
    • (1984) Blood , vol.63 , pp. 671-675
    • Sala, N.1    Owen, W.G.2    Collen, D.3
  • 29
  • 32
    • 0028651903 scopus 로고
    • Laboratory diagnosis of APC resistance: A critical evaluation of the test and the development of diagnostic criteria
    • Ronde de H, Bertina RM. Laboratory diagnosis of APC resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haem 1994; 72: 880-886.
    • (1994) Thromb Haem , vol.72 , pp. 880-886
    • Ronde De, H.1    Bertina, R.M.2
  • 34
    • 0028902902 scopus 로고
    • Sensitivity to activated protein C; influence of oral contraceptives and sex
    • Henkens CMA, Bom VJJ, Seinen AJ, Meer van der J. Sensitivity to activated protein C; influence of oral contraceptives and sex. Thromb Haem 1995; 73: 402-404.
    • (1995) Thromb Haem , vol.73 , pp. 402-404
    • Henkens, C.M.A.1    Bom, V.J.J.2    Seinen, A.J.3    Meer Van Der, J.4
  • 35
    • 0028261675 scopus 로고
    • A new variant of interaction between phospholipid antibodies and the protein C system
    • Bokarewa MI, Blomback M, Egberg N, Rosen S. A new variant of interaction between phospholipid antibodies and the protein C system. Blood Coag Fibrinol 1994; 5: 37-41.
    • (1994) Blood Coag Fibrinol , vol.5 , pp. 37-41
    • Bokarewa, M.I.1    Blomback, M.2    Egberg, N.3    Rosen, S.4
  • 36
    • 0028939187 scopus 로고
    • Use of a generally applicable tissue factor-dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant
    • Le DT, Griffin JH, Greengard JS, Mujumdar V, Rapaport SI. Use of a generally applicable tissue factor-dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant. Blood 1995; 85: 1704-1711.
    • (1995) Blood , vol.85 , pp. 1704-1711
    • Le, D.T.1    Griffin, J.H.2    Greengard, J.S.3    Mujumdar, V.4    Rapaport, S.I.5
  • 37
    • 0030069068 scopus 로고    scopus 로고
    • Influence of heparin, protamine and polybrene on the time integral of thrombin generation (endogenous thrombin potential)
    • Rotteveel RC, Roozendaal KJ, Weijers RNM, Eijsman L. Influence of heparin, protamine and polybrene on the time integral of thrombin generation (endogenous thrombin potential). Haemostasis 1996; 26: 1-10.
    • (1996) Haemostasis , vol.26 , pp. 1-10
    • Rotteveel, R.C.1    Roozendaal, K.J.2    Weijers, R.N.M.3    Eijsman, L.4
  • 38
    • 0000946077 scopus 로고
    • Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers
    • Laudano AP, Doolittle RF. Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. Proc Natl Acad Sci USA 1978; 75: 3085-3089
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 3085-3089
    • Laudano, A.P.1    Doolittle, R.F.2
  • 39
    • 0028358419 scopus 로고
    • Measurement of thrombin generation in whole blood - The effect of heparin and aspirin
    • Kessels H, Béguin S, Andree H, Hemker HC. Measurement of thrombin generation in whole blood - the effect of heparin and aspirin, Thromb Haemost 1994; 72: 78-83.
    • (1994) Thromb Haemost , vol.72 , pp. 78-83
    • Kessels, H.1    Béguin, S.2    Andree, H.3    Hemker, H.C.4
  • 40
    • 0028039182 scopus 로고
    • The effect of subcutaneous injection of unfractionated and low molecular weight heparin on thrombin generation in platelet rich plasma - A study in human volunteers
    • Bendetowiez AV, Kai H, Knebel R, et al. The effect of subcutaneous injection of unfractionated and low molecular weight heparin on thrombin generation in platelet rich plasma - a study in human volunteers. Thromb Haemost 1994; 72: 705-712.
    • (1994) Thromb Haemost , vol.72 , pp. 705-712
    • Bendetowiez, A.V.1    Kai, H.2    Knebel, R.3
  • 41
    • 0028007619 scopus 로고
    • The influence of fibrinogen and fibrin on thrombin generation - Evidence for feedback activation of the clotting system by clot bound thrombin
    • Kumar R, Béguin S, Hemker HC. The influence of fibrinogen and fibrin on thrombin generation - evidence for feedback activation of the clotting system by clot bound thrombin. Thromb Haemost 1994; 72: 713-721.
    • (1994) Thromb Haemost , vol.72 , pp. 713-721
    • Kumar, R.1    Béguin, S.2    Hemker, H.C.3
  • 42
    • 13344260005 scopus 로고
    • Eftect of different progestagens in low oestrogen oral contraceptives on venous thromboemboli
    • World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Eftect of different progestagens in low oestrogen oral contraceptives on venous thromboemboli. Lancet 1995; 346: 1582-1588.
    • (1995) Lancet , vol.346 , pp. 1582-1588


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.