Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris

Journal of Dermatology

Volumn 39, Issue 5, 2012, Pages 433-438

  Akarsu, Sevgi ^a   Fetil, Emel ^a   Yücel, Filiz ^a   Gül, Eylem ^a   Güneş, Ali T ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Acne vulgaris; Benzoyl peroxide; Clindamycin; Salicylic acid; Treatment outcome

Indexed keywords

BENZOYL PEROXIDE; CLINDAMYCIN; SALICYLIC ACID;

ACNE VULGARIS; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRY SKIN; FACE ERYTHEMA; FEMALE; HUMAN; MALE; PRURITUS; QUALITY OF LIFE INDEX; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN ABRASION; SKIN BURNING SENSATION; TREATMENT OUTCOME;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; BENZOYL PEROXIDE; CLINDAMYCIN; DERMATOLOGIC AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; PROSPECTIVE STUDIES; SALICYLIC ACID; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84859795808     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2011.01405.x     Document Type: Article

References (23)

1. Degitz K, Ochsendorf F. Pharmacotherapy of acne. Expert Opin Pharmacother 2008; 9: 955-971. (Pubitemid 351593743)
2. Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol 2003; 49: S200-S210. (Pubitemid 37046534)
3. Krautheim A, Gollnick HPM. Acne: topical treatment. Clin Dermatol 2004; 22: 398-407. (Pubitemid 39535282)
4. Thiboutot D, Gollnick H, Bettoli V et al. New insights into the management of acne: an update from the global alliance to improve outcomes in acne group. J Am Acad Dermatol 2009; 60: S1-S50.
5. Del Rosso JQ, Schmidt NF. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis 2010; 85: 15-24.
6. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004; 64: 2389-2397. (Pubitemid 39472628)
7. Sagransky M, Yentzer BA, Feldman SR. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother 2009; 10: 2555-2562.
8. Taylor GA, Shalita AR. Benzoyl peroxide-based combination therapies for acne vulgaris: a comparative review. Am J Clin Dermatol 2004; 5: 261-265. (Pubitemid 39127968)
9. Waller JM, Dreher F, Behnam S et al. "Keratolytic" properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man. Skin Pharmacol Physiol 2006; 19: 283-289. (Pubitemid 44329095)
10. Cunliffe WJ, Holland KT, Bojar R, Levy SF. A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. Clin Ther 2002; 24: 1117-1133. (Pubitemid 34833234)
11. Leyden JJ, Berger RS, Dunlap FE, Ellis CN, Connolly MA, Levy SF. Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris. Am J Clin Dermatol 2001; 2: 33-39. (Pubitemid 32405892)
12. Bikowski J, Callender VD, Del Rosso JQ, Draelos ZD, Tanghetti E. Combining clindamycin 1%-benzoyl peroxide 5%gel with multiple therapeutic options. Cutis 2006; 78: 13-20.
13. Bowe WP, Shalita AR. Effective over-the-counter acne treatments. Semin Cutan Med Surg 2008; 27: 170-176.
14. Kaminsky A. Less common methods to treat acne. Dermatology 2003; 206: 68-73. (Pubitemid 36167824)
15. Shalita AR. Treatment of mild and moderate acne vulgaris with salicylic acid in an alcohol-detergent vehicle. Cutis 1981; 28: 556-558.
16. Touitou E, Godin B, Shumilov M et al. Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris. J Eur Acad Dermatol Venereol 2008; 22: 629-631. (Pubitemid 351541069)
17. Babayeva L, Akarsu S, Fetil E, Güneş A. Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol 2011; 25: 328-333.
18. Thiboutot D, Eichenfield L, Shalita A et al. A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide. Cutis 2009; 84: 48-55.
19. Seidler EM, Kimball AB. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. J Am Acad Dermatol 2010; 63: 52-62.
20. Bissonnette R, Bolduc C, Seité S et al. Randomized study comparing the efficacy and tolerance of a lipophillic hydroxy acid derivative of salicylic acid and 5% benzoyl peroxide in the treatment of facial acne vulgaris. J Cosmet Dermatol 2009; 8: 19-23.
21. Schmidt JB, Neumann R, Knobler R, Spona J. Sebum suppression by benzoylperoxide. Dermatologica 1985; 170: 165-169. (Pubitemid 15111942)
22. Stinco G, Bragadin G, Trotter D, Pillon B, Patrone P. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. J Eur Acad Dermatol Venereol 2007; 21: 320-325.
23. Zhen Y, Stoudemayer M, Vamvakias G, Kligman AM. Pilot investigation of the hydrating effects of topical acne medications. J Drugs Dermatol 2007; 6: 810-816.