Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne

Journal of the European Academy of Dermatology and Venereology

Volumn 21, Issue 3, 2007, Pages 320-325

  Stinco, Guiseppe ^b   Bragadin, G ^a   Trotter, D ^a   Pillon, B ^a   Patrone, P ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b Gemona Hospital   (Italy)

Author keywords

Acne; Adapalene; Azelaicacid; Benzoylper oxide; Sebumeter

Indexed keywords

ADAPALENE; AZELAIC ACID; BENZOYL PEROXIDE;

ACNE; ADOLESCENT; ADULT; ARTICLE; CHEEK; CHIN; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRY SKIN; ERYTHEMA; FEMALE; FOLLOW UP; FOREHEAD; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PRURITUS; SCHOOL CHILD; SEBUM SECRETION;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ADOLESCENT; ANALYSIS OF VARIANCE; BENZOYL PEROXIDE; CHILD; DERMATOLOGIC AGENTS; DICARBOXYLIC ACIDS; FACIAL DERMATOSES; FEMALE; HUMANS; MALE; NAPHTHALENES; OINTMENTS; SEBUM; TREATMENT OUTCOME;

EID: 33846980450     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2006.01914.x     Document Type: Article

References (25)

1. Leyden JJ. New understanding of the pathogenesis of acne. J Am Acad Dermatol 1995; 32: S15-S25.
2. Pagnoni A, Klingman AM, el Gammal S, Stoudemayer T. Determination of density of follicles on various regions of the face by cyanoacrilate biopsy: Correlation with sebum output. Br J Dermatol 1994; 131: 862-865.
3. Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol 2004; 22: 360-366.
4. Krautheim A, Gollnick HP. Acne: Topical treatment. Clin Dermatol 2004; 22: 398-407.
5. Henderson CA, Taylor J, Cunliffe WJ. Sebum excretion rates in mothers and neonates. Br J Dermatol 2000; 142: 110-111.
6. Pierard-Franchimont C, Pierard GE, Klingman A. Seasonal modulation of sebum excretion. Dermatologica 1990; 181: 21-22.
7. Conti A, Schiavi ME, Seidenari S. Capacitance, transepidermal water loss and causal level of sebum in healthy subjects in relation to site, sex and age. Int J Cosm Sc 1995; 17: 77-85.
8. Pierard GE, Ries G, Cauwenbergh G. New insight into topical management of excessive sebum flow at the skin surface. Dermatology 1998; 196: 126-129.
9. Powell EW, Beveridge GW. Sebum excretion and sebum composition in adolescent and effect on sebum production. Br J Dermatol 1970; 82: 243-249.
10. Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol 2003; 49: S200-S210.
11. Gollnick H. Current concepts of the pathogenesis of acne: Implications for drug treatment. Drugs 2003; 63: 1579-1596.
12. Passi S, Picardo M, De luca C, Nazzaro-Porro M. Meccanismo d'azione dell'azelaic acid nell'acne. G Ital Dermatol Venereol 1989; 124: 455-463.
13. Breathnach AS. Azelaic acid: A new agent in the treatment of acne: history, metabolism and chemistry. J Dermatol Treat 1989; 1: 7-9.
14. Mayer da Silva A, Gollnick H, Detmar M, Gassmuller J, Parry A, Muller R, Orfanos CE. Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. Acta Derm Venereol Suppl (Stockh) 1989; 143: 20-30.
15. Cunliffe WJ, Holland KT. Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. Acta Derm Venereol Suppl (Stockh) 1989 ; 143: 31-34.
16. Bladon PT, Burke BM, Cunliffe WJ, Forster RA, Holland KT, King K. Topical azelaic acid and the treatment of acne: A clinical and laboratory comparison with oral tetracicline. Br J Dermatol 1986; 114: 493-499.
17. Cunliffe WJ, Staiton C, Forster RA. Topical benzoyl peroxide increases the sebum excretion rate in patients with acne. Br J Dermatol 1983; 109: 577-579.
18. Pierard-Franchimont C, Melotte P, Pierard GE. Topical benzoyl peroxide increases the sebum excretion rate. Br J Dermatol 1984; 11: 506.
19. Goldstein JA, Pochi PE. Failure of benzoyl peroxide to decrease sebaceous gland secretion in acne. Dermatologica 1981; 162: 287-291.
20. Schmidt JB, Neumann R, Knobler R, Spona J. Sebum suppression by benzoyl peroxide. Dermatologica 1985; 170: 165-169.
21. Knor T. Effect of retinoid therapy on seborrhea using iontophoresis. Med Arh 2003; 57: 295-298.
22. Anadolu RY, Sen T, Tarimci N, Birol A, Erdem C. Improved efficacy and tolerability of retinoic acid in acne vulgaris: A new topical formulation with cyclodextrin complex ψ. J Eur Acad Dermatol Venereol 2004; 18: 416-421.
23. Puschmann M. Clinico-experimental studies on the effect of benzoyl peroxide. Hautarzt 1982; 33: 257-265.
24. Haustein UF, Tegetmeyer L, Ziegler V. Allergic and irritant potential of benzoyl peroxide. Contact Dermatitis 1985; 13: 252-257.
25. Leyden JJ, Berger RS, Dunlap FE, Ellis CN, Connoly MA, Levy SF. Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris. Am J Clin Dermatol 2001; 2: 33-39.