Socioeconomic support reduces nonretention in a comprehensive, community-based antiretroviral therapy program in Uganda

Journal of Acquired Immune Deficiency Syndromes

Volumn 59, Issue 4, 2012, Pages

  Talisuna Alamo, Stella ^a   Colebunders, Robert ^b,c   Ouma, Joseph ^d   Sunday, Pamela ^a   Ekoru, Kenneth ^e   Laga, Marie ^b   Wagner, Glenn ^f   Wabwire Mangen, Fred ^g  

^a Medical Department   (Uganda)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d Department of Strategic Planning Management Sciences for Health ^*  (Uganda)

^e MAKERERE UNIVERSITY   (Uganda)

^f RAND CORPORATION   (United States)

^g MAKERERE UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Uganda)

Author keywords

Community based care; HIV; Loss to follow up; Mortality; Retained antiretroviral therapy; Socioeconomic support

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; COHORT ANALYSIS; COMMUNITY CARE; FEMALE; FINANCIAL MANAGEMENT; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOCIAL SUPPORT; SOCIOECONOMIC SUPPORT; SOCIOECONOMICS;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; HIV INFECTIONS; HUMANS; INCIDENCE; LOST TO FOLLOW-UP; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SOCIAL SUPPORT; TREATMENT OUTCOME; UGANDA; YOUNG ADULT;

EID: 84859773713     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318246e2aa     Document Type: Article

References (36)

1. Egger M, May M, Chene G, et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002;360:119-129. (Pubitemid 34786200)
2. Hogg RS, Yip B, Kully C, et al. Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens. CMAJ. 1999;160:659-665. (Pubitemid 29149796)
3. Mocroft A, Vella S, Benfield TL, et al. Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group. Lancet. 1998;352:1725-1730. (Pubitemid 28534954)
4. Sterne JA, Hernan MA, Ledergerber B, et al. Long-term effectiveness of potent antiretroviral therapy in preventing AIDS and death: a prospective cohort study. Lancet. 2005;366:378-384. (Pubitemid 41073955)
5. Weidle PJ, Wamai N, Solberg P, et al. Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda. Lancet. 2006;368:1587-1594. (Pubitemid 44767594)
6. Colebunders R, Kamya M, Semitala F, et al. Free antiretrovirals must not be restricted only to treatment-naive patients: experience in Uganda suggests that restricting access is not the way forward. PLoS Med. 2005;2: e276.
7. Chesney MA, Morin M, Sherr L. Adherence to HIV combination therapy. Soc Sci Med. 2000;50:1599-1605. (Pubitemid 30129133)
8. Wallman S, Baker M. Which resources pay for treatment? A model for estimating the informal economy of health. Soc Sci Med. 1996;42: 671-679.
9. Coetzee D, Hildebrand K, Boulle A, et al. Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS. 2004;18:887-895. (Pubitemid 38553709)
10. Goudge J, Govender V. A Review of Experience Concerning Household Ability to Cope With the Resource Demands of Ill-health and Health Care Utilization. Regional Network for Equity in Health in Southern Africa (Equinet) Policy Series No. 3. Harare, Zimbabwe: Training and Resource Centre; 2000.
11. Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006; 296:679-690. (Pubitemid 44200639)
12. Bekker LG, Orrell C, Reader L, et al. Antiretroviral therapy in a community clinic: early lessons from a pilot project. S Afr Med J. 2003;93:458-462.
13. Stringer JS, Zulu I, Levy J, et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA. 2006;296:782-793. (Pubitemid 44223102)
14. Boulle A, Bock P, Osler M, et al. Antiretroviral therapy and early mortality in South Africa. Bull World Health Organ. 2008;86:678-687.
15. Braitstein P, Brinkhof MW, Dabis F, et al. Mortality of HIV-1 infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006;367:817-824.
16. Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med. 2007;4:e298.
17. Mills EJ, Nachega JB, Bangsberg DR, et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006;3:e438.
18. Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34:281-288. (Pubitemid 37377361)
19. Nash D, Korves C, Saito S, et al. Characteristics of facilities and programs delivering HIV care and treatment services are associated with loss to follow-up rates in programs from 7 Sub-Saharan African countries. Fifteenth Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 2008. [abstract 838]. Available at: http://www.retroconference.org/2008/ Abstracts/33224.htm Accessed October 15, 2009.
20. Lawn SD, Kaplan R, Wood R, et al. Promoting retention in care: an effective model in an antiretroviral treatment service in South Africa. Clin Infect Dis. 2007;45:803.3.
21. Larry WC, Alamo S, Guma S, et al. Two year virologic outcomes of an alternative AIDS care model: evaluation of a peer health worker and nurse-staffed community-based programme in Uganda. J Acquir Immune Defic Syndr. 2009;50:276-282.
22. Amanyire G, Wanyenze R, Alamo S, et al. Client and provider perspectives of the efficiency and quality of care in the context of rapid scale-up of antiretroviral therapy. AIDS Patient Care STDS. 2010;24:441-446.
23. WFP/UNHCR. UN/Inter-agency Guidelines WFP/UNHCR Joint Assessment Guidelines (JAMs), March 2009.
24. FAO/WFP. Joint Guidelines for Crop & Food Security Assessment Missions (CFSAMs), January 2009.
25. IASC. Initial Rapid Assessment (IRA): Guidance Notes & Field Assessment Form.
26. UNAIDS, UNICEF, USAID, WFP and FAO. An Update on the National Plans of Action for Orphans and Children Made Vulnerable by HIV/AIDS and the Second Phase of the Rapid Assessment, Analysis and Action Planning Process. New York, NY: UNICEF; 2005.
27. WHO/UNAIDS. Access to HIV Treatment Continues to Accelerate in Developing Countries, but Bottlenecks Persist. Geneva, Switzerland: World Health Organization; 2005.
28. Bassett IV, Wang B, Chetty S, et al. Loss to care and death before antiretroviral therapy in Durban, South Africa. J Acquir Immune Defic Syndr. 2009;51:135-139.
29. Losina E, Bassett IV, Giddy J, et al. The "ART" of linkage: early loss to follow-up (LTFU) after HIV diagnosis at two PEPFAR sites in Durban, South Africa. Presented at: XVIIth International AIDS Society Meeting; August 3-8, 2008; Mexico City, Mexico. Poster TUPE0345.
30. Wools-Kaloustian K, Kimaiyo S, Diero L, et al. Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from Western Kenya. AIDS. 2006;20:41-48. (Pubitemid 41818113)
31. Mills EJ, Bakandab C, Birungi J. Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda. AIDS. 2011;25:851-855.
32. Zachariah R, Teck R, Buhendwa L, et al. Community support is associated with better antiretroviral treatment outcomes in a resource-limited rural district in Malawi. Trans R Soc Trop Med Hyg. 2007;101:79-84. (Pubitemid 44760916)
33. Maskew M, Mac Phail P, Menezes C, et al. Lost to follow up: contributing factors and challenges in South African patients on antiretroviral therapy. S Afr Med J. 2007;97:853-857. (Pubitemid 47542654)
34. Yu JK, Chen SC, Wang KY, et al. True outcomes of patients on antiretroviral therapy who are "lost to follow up" in Malawi. Bull World Health Organ. 2007;85:550-554. (Pubitemid 47041634)
35. Bisson GP, Gaolathe T, Gross R, et al. Overestimates of survival after HAART: implications for global scale-up efforts. PLoS One. 2008;3:e175.
36. Lawn SD, Myer L, Harling G, et al. Determinants of mortality and nondeath losses from an antiretroviral treatment service in South Africa: implications from program evaluations. Clin Infect Dis. 2006;43: 770-776. (Pubitemid 44330743)