An improved methodology for multidimensional high-throughput preformulation characterization of protein conformational stability

Journal of Pharmaceutical Sciences

Volumn 101, Issue 6, 2012, Pages 2017-2024

  Maddux, Nathaniel R ^a   Rosen, Ilan T ^a,b   Hu, Lei ^a   Olsen, Christopher M ^a   Volkin, David B ^a   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Absorbance; Calorimetry; Circular dichroism; Fluorescence; Formulation; Light scattering; Phase diagrams; Protein; Stability; Vaccines

Indexed keywords

BOVINE SERUM ALBUMIN; CHYMOTRYPSIN A; FRUCTOSE BISPHOSPHATE ALDOLASE; LYSOZYME;

ARTICLE; CIRCULAR DICHROISM; DATA ANALYSIS SOFTWARE; EMPIRICAL PHASE DIAGRAM; FLUORESCENCE SPECTROSCOPY; HIGH THROUGHPUT SEQUENCING; LIGHT ABSORPTION; LIGHT SCATTERING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN STABILITY; REPRODUCIBILITY;

EID: 84859769263     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23132     Document Type: Article

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