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Volumn 27, Issue 5, 2012, Pages 285-296

Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice

Author keywords

Interleukin 1 ; Interleukin 6; Lipopolysaccharide; Perfluorooctanesulfonate; Tumor necrosis factor

Indexed keywords

INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; PERFLUOROOCTANE SULFONATES; TUMOR NECROSIS FACTORS;

EID: 84859769112     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20642     Document Type: Article
Times cited : (40)

References (53)
  • 1
    • 84859767535 scopus 로고    scopus 로고
    • 3M Company. 104-week dietary chronic toxicity and carcinogenicity study with perfluorooctane sulfonic acid potassium salt (PFOS; T-6295) in rats. Final Report, 3M T-6295 (Covance study no.:6329-183), Volumes I-IX, 4068 pages, January 2, 2002. 3M, St. Paul, Minnesota.
    • 3M Company. 2002. 104-week dietary chronic toxicity and carcinogenicity study with perfluorooctane sulfonic acid potassium salt (PFOS; T-6295) in rats. Final Report, 3M T-6295 (Covance study no.:6329-183), Volumes I-IX, 4068 pages, January 2, 2002. 3M, St. Paul, Minnesota.
    • (2002)
  • 2
    • 64949195390 scopus 로고    scopus 로고
    • Review of the expression of peroxisome proliferators activated receptors alpha (PPAR-alpha), beta (PPAR-beta), and gamma (PPAR-gamma) in rodent and human development
    • Abbott BD. 2009. Review of the expression of peroxisome proliferators activated receptors alpha (PPAR-alpha), beta (PPAR-beta), and gamma (PPAR-gamma) in rodent and human development. Reprod Toxicol 27: 246-257.
    • (2009) Reprod Toxicol , vol.27 , pp. 246-257
    • Abbott, B.D.1
  • 4
    • 23944474287 scopus 로고    scopus 로고
    • Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas)
    • Ankley GT, Kuehl DW, Kahl MD, Jensen KM, Linnum A, Leino RL, Villeneuvet DA. 2005. Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem 24: 2316-2324.
    • (2005) Environ Toxicol Chem , vol.24 , pp. 2316-2324
    • Ankley, G.T.1    Kuehl, D.W.2    Kahl, M.D.3    Jensen, K.M.4    Linnum, A.5    Leino, R.L.6    Villeneuvet, D.A.7
  • 5
    • 44649141915 scopus 로고    scopus 로고
    • The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha
    • Asakawa A, Toyoshima M, Harada KH, Fujimiya M, Inoue K, Koizumi A. 2008. The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha. Int J Mol Med 21: 439-445.
    • (2008) Int J Mol Med , vol.21 , pp. 439-445
    • Asakawa, A.1    Toyoshima, M.2    Harada, K.H.3    Fujimiya, M.4    Inoue, K.5    Koizumi, A.6
  • 6
    • 33845524008 scopus 로고    scopus 로고
    • TNF-alpha in promotion and progression of cancer
    • Balkwill F. 2006. TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev 25: 409-416.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 409-416
    • Balkwill, F.1
  • 7
    • 26444449880 scopus 로고    scopus 로고
    • Effects of feed restriction on the nucleolar structure and function in lymphocytes
    • Berger J, Machackova M, Berger Z. 2005. Effects of feed restriction on the nucleolar structure and function in lymphocytes. Basic Clin Pharmacol Toxicol 97: 236-237.
    • (2005) Basic Clin Pharmacol Toxicol , vol.97 , pp. 236-237
    • Berger, J.1    Machackova, M.2    Berger, Z.3
  • 8
    • 84859739167 scopus 로고    scopus 로고
    • Determination of serum half-lives of several fluorochemicals. Interim Report No. 2. St. Paul,MN:3M Company. U.S. EPA docket AR-226-1086. Washington, DC:U.S. Environmental Protection Agency.
    • Burris JM, Lundberg JK, Olsen GW, Simpson C, Mandel JH. 2002. Determination of serum half-lives of several fluorochemicals. Interim Report No. 2. St. Paul, MN:3M Company. U.S. EPA docket AR-226-1086. Washington, DC:U.S. Environmental Protection Agency.
    • (2002)
    • Burris, J.M.1    Lundberg, J.K.2    Olsen, G.W.3    Simpson, C.4    Mandel, J.H.5
  • 9
    • 34247120708 scopus 로고    scopus 로고
    • Serum concentrations of 11 polyfluoroalkyl compounds in the U.S. population: Data from the national health and nutrition examination survey (NHANES)
    • Calafat AM, Kuklenyik Z, Reidy JA.Caudill SP, Tully JS, Needham LL. 2007. Serum concentrations of 11 polyfluoroalkyl compounds in the U.S. population: Data from the national health and nutrition examination survey (NHANES). Environ Sci Technol 41: 2237-2242.
    • (2007) Environ Sci Technol , vol.41 , pp. 2237-2242
    • Calafat, A.M.1    Kuklenyik, Z.2    Reidy, J.A.3    Caudill, S.P.4    Tully, J.S.5    Needham, L.L.6
  • 10
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    • Chinetti G, Fruchart JC, Staels B. 2000. Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49: 497-505.
    • (2000) Inflamm Res , vol.49 , pp. 497-505
    • Chinetti, G.1    Fruchart, J.C.2    Staels, B.3
  • 11
    • 77949506489 scopus 로고    scopus 로고
    • Dietary intake estimate for perfluorooctanesulphonic acid (PFOS) and other perfluorocompounds (PFCs) in UK retail foods following determination using standard addition LC-MS/MS
    • Clarke DB, Bailey VA, Routledge A, Lloyd AS, Hird S, Mortimer DN, Gem M. 2010. Dietary intake estimate for perfluorooctanesulphonic acid (PFOS) and other perfluorocompounds (PFCs) in UK retail foods following determination using standard addition LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27: 530-545.
    • (2010) Food Addit Contam Part A Chem Anal Control Expo Risk Assess , vol.27 , pp. 530-545
    • Clarke, D.B.1    Bailey, V.A.2    Routledge, A.3    Lloyd, A.S.4    Hird, S.5    Mortimer, D.N.6    Gem, M.7
  • 13
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • Daynes RA, Jones DC. 2002. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2: 748-759.
    • (2002) Nat Rev Immunol , vol.2 , pp. 748-759
    • Daynes, R.A.1    Jones, D.C.2
  • 16
    • 45549094021 scopus 로고    scopus 로고
    • Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice
    • DeWitt JC, Copeland CB, Strynar MJ, Luebke RW. 2008. Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environ Health Perspect 116: 644-650.
    • (2008) Environ Health Perspect , vol.116 , pp. 644-650
    • DeWitt, J.C.1    Copeland, C.B.2    Strynar, M.J.3    Luebke, R.W.4
  • 17
    • 68849106955 scopus 로고    scopus 로고
    • Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL/6 mice
    • Dong GH, Zhang YH, Zheng L, Liu W, Jin YH, He QC. 2009. Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL/6 mice. Arch Toxicol 83: 805-815.
    • (2009) Arch Toxicol , vol.83 , pp. 805-815
    • Dong, G.H.1    Zhang, Y.H.2    Zheng, L.3    Liu, W.4    Jin, Y.H.5    He, Q.C.6
  • 18
    • 79951949318 scopus 로고    scopus 로고
    • An assessment of the exposure of Americans to perfluorooctane sulfonate: A comparison of estimated intake with values inferred from NHANES data
    • doi:10.1038/jes.2009.73.
    • Egeghy PP, Lorber M. 2010. An assessment of the exposure of Americans to perfluorooctane sulfonate: A comparison of estimated intake with values inferred from NHANES data. J Expo Sci Environ Epidemiol doi:10.1038/jes.2009.73.
    • (2010) J Expo Sci Environ Epidemiol
    • Egeghy, P.P.1    Lorber, M.2
  • 19
    • 0035298680 scopus 로고    scopus 로고
    • Global distribution of perfluorooctane sulfonate in wildlife
    • Giesy JP, Kannan K. 2001. Global distribution of perfluorooctane sulfonate in wildlife. Environ Sci Technol 35: 1339-1342.
    • (2001) Environ Sci Technol , vol.35 , pp. 1339-1342
    • Giesy, J.P.1    Kannan, K.2
  • 20
    • 0035865117 scopus 로고    scopus 로고
    • Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
    • Hansen KJ, Clemen LA, Ellefson ME, Johnson HO. 2001. Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices. Environ Sci Technol 35: 766-770.
    • (2001) Environ Sci Technol , vol.35 , pp. 766-770
    • Hansen, K.J.1    Clemen, L.A.2    Ellefson, M.E.3    Johnson, H.O.4
  • 21
    • 0028670345 scopus 로고
    • Comparison of the toxicity of cinnamaldehyde when administered by microencapsulation in feed or by corn oil gavage
    • Hebert CD, Yuan J, Dieter MP. 1994. Comparison of the toxicity of cinnamaldehyde when administered by microencapsulation in feed or by corn oil gavage. Food Chem Toxicol 32: 1107-1115.
    • (1994) Food Chem Toxicol , vol.32 , pp. 1107-1115
    • Hebert, C.D.1    Yuan, J.2    Dieter, M.P.3
  • 22
    • 2542593145 scopus 로고    scopus 로고
    • Dietary repletion can replenish reduced T cell subset numbers and lymphoid organ weight in zinc-deficient and energy-restricted rats
    • Hosea HJ, Rector ES, Taylor CG. 2004. Dietary repletion can replenish reduced T cell subset numbers and lymphoid organ weight in zinc-deficient and energy-restricted rats. Br J Nutr 91: 741-747.
    • (2004) Br J Nutr , vol.91 , pp. 741-747
    • Hosea, H.J.1    Rector, E.S.2    Taylor, C.G.3
  • 25
    • 34248175235 scopus 로고    scopus 로고
    • Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China
    • Jin Y, Saito N, Harada KH, Inoue K, Koizumi A. 2007. Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China. Tohoku J Exp Med 212: 63-70.
    • (2007) Tohoku J Exp Med , vol.212 , pp. 63-70
    • Jin, Y.1    Saito, N.2    Harada, K.H.3    Inoue, K.4    Koizumi, A.5
  • 28
    • 42149179865 scopus 로고    scopus 로고
    • Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 Mice
    • Keil DE, Mehlmann T, Butterworth L, Peden-Adams MM. 2008. Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 Mice. Toxicol Sci 103: 77-85.
    • (2008) Toxicol Sci , vol.103 , pp. 77-85
    • Keil, D.E.1    Mehlmann, T.2    Butterworth, L.3    Peden-Adams, M.M.4
  • 29
    • 1642400099 scopus 로고    scopus 로고
    • Mercury-induced apoptosis and necrosis in murine macrophages: Role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling
    • Kim SH, Sharma RP. 2004. Mercury-induced apoptosis and necrosis in murine macrophages: Role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol 196: 47-57.
    • (2004) Toxicol Appl Pharmacol , vol.196 , pp. 47-57
    • Kim, S.H.1    Sharma, R.P.2
  • 30
    • 33845961349 scopus 로고    scopus 로고
    • Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A. 1 murine macrophages
    • Kim SH, Lee S, Suk K, Bark H, Jun CD, Kim DK, Choi CH, Yoshimura T. 2007. Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A. 1 murine macrophages. Free Radic Biol Med 42: 343-352.
    • (2007) Free Radic Biol Med , vol.42 , pp. 343-352
    • Kim, S.H.1    Lee, S.2    Suk, K.3    Bark, H.4    Jun, C.D.5    Kim, D.K.6    Choi, C.H.7    Yoshimura, T.8
  • 32
    • 48049084135 scopus 로고    scopus 로고
    • The cytokine hypothesis of depression: inflammation, oxidative and nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression
    • Maes M. 2008. The cytokine hypothesis of depression: inflammation, oxidative and nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett 29: 287-291.
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 287-291
    • Maes, M.1
  • 33
    • 77951707570 scopus 로고    scopus 로고
    • Association between serum perfluoroctanoic acid (PFOA) and thyroid disease in the NHANES study
    • doi:10.1289/ehp.0901584.
    • Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS. 2010. Association between serum perfluoroctanoic acid (PFOA) and thyroid disease in the NHANES study. Environ Health Perspect doi:10.1289/ehp.0901584.
    • (2010) Environ Health Perspect
    • Melzer, D.1    Rice, N.2    Depledge, M.H.3    Henley, W.E.4    Galloway, T.S.5
  • 35
    • 84859740925 scopus 로고    scopus 로고
    • Organization for Economic Co-operation and Development. Hanzard assessment of perfluorooctane sulfonate (PFOS) and its salts.
    • Organization for Economic Co-operation and Development. 2002. Hanzard assessment of perfluorooctane sulfonate (PFOS) and its salts. Available at:
    • (2002)
  • 36
    • 67651051836 scopus 로고    scopus 로고
    • High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a similar fashion
    • Qazi MR, Bogdanska J, Butenhoff JL, Nelson BD, DePierre JW, Abedi-Valugerdi M. 2009a. High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a similar fashion. Toxicology 262: 207-214.
    • (2009) Toxicology , vol.262 , pp. 207-214
    • Qazi, M.R.1    Bogdanska, J.2    Butenhoff, J.L.3    Nelson, B.D.4    DePierre, J.W.5    Abedi-Valugerdi, M.6
  • 37
    • 67349112418 scopus 로고    scopus 로고
    • The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPAR-alpha)
    • Qazi MR, Xia Z, Bogdanska J, Chang SC, Ehresman DJ, Butenhoff JL, Nelson BD, DePierre JW, Abedi-Valugerdi M. 2009b. The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Toxicology 260: 68-76.
    • (2009) Toxicology , vol.260 , pp. 68-76
    • Qazi, M.R.1    Xia, Z.2    Bogdanska, J.3    Chang, S.C.4    Ehresman, D.J.5    Butenhoff, J.L.6    Nelson, B.D.7    DePierre, J.W.8    Abedi-Valugerdi, M.9
  • 38
    • 71849098790 scopus 로고    scopus 로고
    • 28-Day dietary exposure of mice to a low total dose (7 mg/kg) of perfluorooctanesulfonate (PFOS) alters neither the cellular compositions of the thymus and spleen nor humoral immune responses: Does the route of administration play a pivotal role in PFOS-induced immunotoxicity?
    • Qazi MR, Nelson BD, Depierre JW, Abedi-Valugerdi M. 2010. 28-Day dietary exposure of mice to a low total dose (7 mg/kg) of perfluorooctanesulfonate (PFOS) alters neither the cellular compositions of the thymus and spleen nor humoral immune responses: Does the route of administration play a pivotal role in PFOS-induced immunotoxicity? Toxicology 267: 132-139.
    • (2010) Toxicology , vol.267 , pp. 132-139
    • Qazi, M.R.1    Nelson, B.D.2    Depierre, J.W.3    Abedi-Valugerdi, M.4
  • 40
    • 0033406251 scopus 로고    scopus 로고
    • Peroxisome proliferators: Mechanisms of adverse effects in rodents and molecular basis for species differences
    • Roberts RA. 1999. Peroxisome proliferators: Mechanisms of adverse effects in rodents and molecular basis for species differences. Arch Toxicol 73(8/9): 413-418.
    • (1999) Arch Toxicol , vol.73 , Issue.8-9 , pp. 413-418
    • Roberts, R.A.1
  • 41
    • 0027159920 scopus 로고
    • Clinical detection of LPS and animal models of endotoxemia
    • Redl H, Bahrami S, Schlag G, Traber DL. 1993. Clinical detection of LPS and animal models of endotoxemia. Immunobiology 187: 330-345.
    • (1993) Immunobiology , vol.187 , pp. 330-345
    • Redl, H.1    Bahrami, S.2    Schlag, G.3    Traber, D.L.4
  • 42
    • 0029076291 scopus 로고
    • Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection
    • Salkowski CA, Neta R, Wynn TA, Strassmann G, van Rooijen N, Vogel SN. 1995. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol 155: 3168-3179.
    • (1995) J Immunol , vol.155 , pp. 3168-3179
    • Salkowski, C.A.1    Neta, R.2    Wynn, T.A.3    Strassmann, G.4    van Rooijen, N.5    Vogel, S.N.6
  • 44
    • 72149128887 scopus 로고    scopus 로고
    • Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice
    • Son HY, Lee S, Tak EN, Cho HS, Shin HI, Kim SH, Yang JH. 2009. Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice. Environ Toxicol 24: 580-588.
    • (2009) Environ Toxicol , vol.24 , pp. 580-588
    • Son, H.Y.1    Lee, S.2    Tak, E.N.3    Cho, H.S.4    Shin, H.I.5    Kim, S.H.6    Yang, J.H.7
  • 45
    • 77249103036 scopus 로고    scopus 로고
    • Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA
    • Steenland K, Tinker S, Shankar A, Ducatman A. 2010. Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA. Environ Health Perspect 118: 229-233.
    • (2010) Environ Health Perspect , vol.118 , pp. 229-233
    • Steenland, K.1    Tinker, S.2    Shankar, A.3    Ducatman, A.4
  • 46
    • 70349484227 scopus 로고    scopus 로고
    • Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome
    • Stein CR, Savitz DA, Dougan M. 2009. Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome. Am J Epidemiol 170: 837-846.
    • (2009) Am J Epidemiol , vol.170 , pp. 837-846
    • Stein, C.R.1    Savitz, D.A.2    Dougan, M.3
  • 48
    • 1842769377 scopus 로고    scopus 로고
    • Secondary immunodeficiency
    • Roitt I, Brostoff J,Male DK, editors., 6th ed. Edinburgh, Scotland: Mosby.
    • Weller I. 2001. Secondary immunodeficiency. In: Roitt I, Brostoff J, Male DK, editors. Immunology, 6th ed. Edinburgh, Scotland: Mosby. pp 315-317.
    • (2001) Immunology , pp. 315-317
    • Weller, I.1
  • 49
    • 0035501236 scopus 로고    scopus 로고
    • Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluorooctanoic acid in mice
    • Yang Q, Xie Y, Eriksson AM, Nelson BD, DePierre JW. 2001. Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluorooctanoic acid in mice. Biochem Pharmacol 62: 1133-1140.
    • (2001) Biochem Pharmacol , vol.62 , pp. 1133-1140
    • Yang, Q.1    Xie, Y.2    Eriksson, A.M.3    Nelson, B.D.4    DePierre, J.W.5
  • 50
    • 0036149365 scopus 로고    scopus 로고
    • Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator,perfluorooctanoic acid
    • Yang Q, Abedi-Valugerdi M, Xie Y, Zhao XY, Moller G, Nelson BD, DePierre JW. 2002. Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid. Int Immunopharmacol 2(2/3): 389-397.
    • (2002) Int Immunopharmacol , vol.2 , Issue.2-3 , pp. 389-397
    • Yang, Q.1    Abedi-Valugerdi, M.2    Xie, Y.3    Zhao, X.Y.4    Moller, G.5    Nelson, B.D.6    DePierre, J.W.7
  • 51
    • 67249099546 scopus 로고    scopus 로고
    • Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism
    • Yu WG, Liu W, Jin YH. 2009. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environ Toxicol Chem 28: 990-996.
    • (2009) Environ Toxicol Chem , vol.28 , pp. 990-996
    • Yu, W.G.1    Liu, W.2    Jin, Y.H.3
  • 53
    • 67650915703 scopus 로고    scopus 로고
    • Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL/6 mice
    • Zheng L, Dong GH, Jin YH, He QC. 2009. Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL/6 mice. Arch Toxicol 83: 679-689.
    • (2009) Arch Toxicol , vol.83 , pp. 679-689
    • Zheng, L.1    Dong, G.H.2    Jin, Y.H.3    He, Q.C.4


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