Iron deficiency in blood donors: The REDS-II Donor Iron Status Evaluation (RISE) study

Transfusion

Volumn 52, Issue 4, 2012, Pages 702-711

  Cable, Ritchard G ^{a,b,c,d,e,f,g,h,i}   Glynn, Simone A ^{a,b,c,d,e,f,g,h,i}   Kiss, Joseph E ^{a,b,c,d,e,f,g,h,i}   Mast, Alan E ^{a,b,c,d,e,f,g,h,i}   Steele, Whitney R ^{a,b,c,d,e,f,g,h,i}   Murphy, Edward L ^{a,b,c,d,e,f,g,h,i}   Wright, David J ^{a,b,c,d,e,f,g,h,i}   Sacher, Ronald A ^{a,b,c,d,e,f,g,h,i}   Gottschall, Jerry L ^{a,b,c,d,e,f,g,h,i}   Tobler, Leslie H ^{a,b,c,d,e,f,g,h,i}   Simon, Toby L ^{a,b,c,d,e,f,g,h,i}  

^a AMERICAN RED CROSS BLOOD SERVICES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c INSTITUTE FOR TRANSFUSION MEDICINE   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e WESTAT   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^h UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

ⁱ CSL Plasma   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IRON; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; ERYTHROPOIESIS; FEMALE; HUMAN; IRON DEFICIENCY; IRON DEPLETION; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; RACE; SEX;

ADULT; AGED; BLOOD DONORS; CROSS-SECTIONAL STUDIES; FEMALE; HEMOGLOBINS; HUMANS; IRON; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SMOKING;

EID: 84859761810     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2011.03401.x     Document Type: Article

References (28)

1. Simon TL, Garry PJ, Hooper EM,. Iron stores in blood donors. JAMA 1981; 245: 2038-43.
2. Mast AE, Foster TM, Pinder HL, Beczkiewicz CA, Bellissimo DB, Murphy AT, Kovacevic S, Wroblewski VJ, Witcher DR,. Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors. Transfusion 2008; 48: 2197.
3. Finch CA, Cook JD, Labbe RF, Culala M,. Effect of blood donation on iron stores as evaluated by serum ferritin. Blood 1977; 50: 441-7.
4. Newman B,. Iron depletion by whole-blood donation harms menstruating females: the current whole-blood-collection paradigm needs to be changed. Transfusion 2006; 46: 1667-81.
5. Sullivan JL,. Stored iron and vascular reactivity. Arterioscler Thromb Vasc Biol 2005; 25: 1532-5.
6. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, Malenka DJ, Ozaki CK, Lavori PW,. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 2008; 100: 996-1002.
7. Lee PL, Halloran C, Trevino R, Felitti V, Beutler E,. Human transferrin G277S mutation: a risk factor for iron deficiency anemia. Br J Haematol 2001; 115: 329-33.
8. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P,; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 2005; 352: 1769-78.
9. Feder JN, Gnirke A, Thomas W, Suchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK,. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13: 399-408.
10. Cable RG, Glynn SA, Kiss JE, Mast AE, Steele WR, Murphy EL, Wright DJ, Sacher RA, Gottschall JL, Vij V, Simon TL,; NHLBI Retrovirus Epidemiology Donor Study-II. Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study. Transfusion 2011; 51: 511-22.
11. American Association of Blood Banks. Standards for blood banks and transfusion services. 26th ed. Bethesda (MD): AABB; 2009. p. 56. Standard 5.4.1A.
12. Code of Federal Regulations. Suitability of Donor. 21 CFR 640.3 (b) (3) (2011).
13. Melmed R, Cable RG, Wright DJ,. Modeling pre-donation venous hemoglobin from post-donation venous hemoglobin. Transfusion 2009; 49: 41A.
14. Punnonen K, Irjala K, Rajamaki A,. Serum transferrin receptor and its ratio to serum ferritin in diagnosis of iron-deficiency anemia. Blood 1997; 89: 1052-7.
15. Punnonen K, Rajamaki A,. Evaluation of iron status of Finnish blood donors using serum transferrin receptor. Transfus Med 1999; 9: 131-4.
16. Radtke H, Meyer T, Kalus U, Röcker L, Salama A, Kiesewetter H, Latza R,. Rapid identification of iron deficiency in blood donors with red cell indexes provided by Advia 120. Transfusion 2005; 45: 5-10.
17. Ali MA, Luxton AW, Walker WH,. Serum ferritin concentration and bone marrow iron stores: a prospective study. Can Med Assoc J 1978; 118: 945-6.
18. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA,. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990; 75: 102-7.
19. Skikne BS, Flowers CH, Cook JD,. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 1990; 75: 1870-6.
20. Department of Health and Human Services. The 2007 national blood collection and utilization survey report. [cited 2011 Oct 4]. Available from: URL
21. Røsvik AS, Ulvik RJ, Wentzel-Larsen T, Hervig T,. The effect of blood donation frequency on iron status. Transfus Apher Sci 2009; 41: 165-9.
22. Bahrami SH, Guiltinan AM, Schlumpf KS, Scott E, Banks LL, D'Andrea P, Hartman EL, Vij V, Wright DJ, Spencer B, Murphy EL, for the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). Donation frequency of blood donors participating in a prospective cohort study of iron status. Transfusion 2011; 51: 1207-12.
23. Mast A, Schlumpf K, Wright D, Custer B, Spencer B, Murphy EL, Simon TL,; NHLBI Retrovirus Epidemiology Donor Study-II. Demographic correlates of low hematocrit deferral among prospective whole blood donors. Transfusion 2010; 50: 1794-802.
24. Pynaert I, De Bacquer D, Matthys C, Delanghe J, Temmerman M, De Backer G, De Henauw S,. Determinants of ferritin and soluble transferrin receptors as iron status parameters in young adult women. Public Health Nutr 2009; 12: 1775-82.
25. Milman N, Kirchhoff M,. Relationship between serum ferritin and risk factors for ischaemic heart disease in 2235 Danes, aged 30-60 years. J Int Med 1999; 245: 423-33.
26. National Center for Chronic Disease Prevention and Health Promotion, CDC. Behavioral risk factor surveillance system. Prevalence and trends data; nationwide-2002 vs 2009 tobacco use. [cited 2011 Oct 4]. Available from: URL
27. Nordenberg D, Yip R, Binkin NJ,. The effect of cigarette smoking on hemoglobin levels and anemia screening. JAMA 1990; 264: 1556-9.
28. Bianco C, Brittenham G, Gilcher RO, Gordeuk VR, Kushner JP, Sayers M, Chambers L, Counts RB, Aylesworth C, Nemo G, Alving B,. Maintaining iron balance in women blood donors of childbearing age: summary of a workshop. Transfusion 2002; 42: 798-805.