Contribution of alcoholism to brain dysmorphology in HIV infection: Effects on the ventricles and corpus callosum

NeuroImage

Volumn 33, Issue 1, 2006, Pages 239-251

  Pfefferbaum, Adolf ^a,b   Rosenbloom, Margaret J ^a,b   Rohlfing, Torsten ^a   Adalsteinsson, Elfar ^c   Kemper, Carol A ^b   Deresinski, Stanley ^b   Sullivan, Edith V ^b  

^a SRI INTERNATIONAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; ALCOHOLISM; ARTICLE; BRAIN REGION; BRAIN SIZE; BRAIN VENTRICLE; BRAIN VENTRICLE DILATATION; CD4 LYMPHOCYTE COUNT; COMORBIDITY; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR; STATISTICAL SIGNIFICANCE; TERATOLOGY; VIRUS LOAD;

ADULT; ALCOHOLISM; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CEREBRAL VENTRICLES; CORPUS CALLOSUM; ECHO-PLANAR IMAGING; FEMALE; HIV INFECTIONS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 33748704918     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2006.05.052     Document Type: Article

References (99)

1. Archibald S.L., Masliah E., Fennema-Notestine C., Marcotte T.D., Ellis R.J., McCutchan J.A., Heaton R.K., Grant I., Mallory M., Miller A., and Jernigan T.L. Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss. Arch. Neurol. 61 (2004) 369-376
2. Aylward E.H., Brettschneider P.D., McArthur J.C., Harris G.J., Schlaepfer T.E., Henderer J.D., Barta P.E., Tien A.Y., and Pearlson G.D. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am. J. Psychiatry 152 (1995) 987-994
3. Beck A.T., Steer R.A., and Brown G.K. Manual for the Beck Depression Inventory-II (1996), Psychological Corporation, San Antonio, TX
4. 2+-mediated neurotoxicity. Neuroscience 104 (2001) 769-781
5. Belmadani A., Neafsey E.J., and Collins M.A. Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations. J. NeuroVirol. 9 (2003) 45-54
6. Bornstein R.A., Chakeres D., Brogan M., Nasrallah H.A., Fass R.J., Para M.F., and Whitacre C.C. Magnetic resonance imaging of white matter lesions in HIV infection. J. Neuropsychiatry Clin. Neurosci. 4 (1992) 174-178
7. Braithwaite R.S., McGinnis K.A., Conigliaro J., Maisto S.A., Crystal S., Day N., Cook R.L., Gordon A., Bridges M.W., Seiler J.F., and Justice A.C. A temporal and dose-response association between alcohol consumption and medication adherence among veterans in care. Alcohol.: Clin. Exp. Res. 29 (2005) 1190-1197
8. Budka H. Neuropathology of myelitis, myelopathy, and spinal infections in AIDS. Neuroimaging Clin. N. Am. (Neuroimaging of AIDS II) 7 (1997) 639-650
9. Cardenas V.A., Studholme C., Meyerhoff D.J., Song E., and Weiner M.W. Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes. Psychiatry Res. 138 (2005) 115-130
10. Carlen P.L., Wortzman G., Holgate R.C., Wilkinson D.A., and Rankin J.G. Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science 200 (1978) 1076-1078
11. CASCADE Collaboration. Survival after introduction of HAART in people with known duration of HIV-1 infection. Lancet 355 (2000) 1158-1159
12. Chang L., Speck O., Miller E.N., Braun J., Jovicich J., Koch C., Itti L., and Ernst T. Neural correlates of attention and working memory deficits in HIV patients. Neurology 57 (2001) 1001-1007
13. Chang L., Lee P.L., Yiannoutsos C.T., Ernst T., Marra C.M., Richards T., Kolson D., Schifitto G., Jarvik J.G., Miller E.N., Lenkinski R., Gonzalez G., and Navia B.A. A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age. NeuroImage 23 (2004) 1336-1347
14. Chen W., Tang Z., Fortina P., Patel P., Addya S., Surrey S., Acheampong E.A., Mukhtar M., and Pomerantz R.J. Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virology 334 (2005) 59-73
15. Collins D.L., Zijdenbos A.P., Kollokian V., Sled J.G., Kabani N.J., Holmes C.J., and Evans A.C. Design and construction of a realistic digital brain phantom. IEEE Trans. Med. Imaging 17 (1998) 463-468
16. Collins M.A., Neafsey E.J., and Zou J.Y. HIV-I gpI20 neurotoxicity in brain cultures is prevented by moderate ethanol pretreatment. NeuroReport 11 (2000) 1219-1222
17. Cook R.L., Sereika S.M., Hunt S.C., Woodward W.C., Erlen J.A., and Conigliaro J. Problem drinking and medication adherence among persons with HIV infection. J. Gen. Int. Med. 16 (2001) 68-83
18. Crovitz H.F., and Zener K.A. Group test for assessing hand and eye dominance. Am. J. Psychol. 75 (1962) 271-276
19. Dal Pan G.J., McArthur J.H., Aylward E., Selnes O.A., Nance-Sproson T.E., Kumar A.J., Mellits E.D., and McArthur J.C. Patterns of cerebral atrophy in HIV-1-infected individuals-Results of a quantitative MRI analysis. Neurology 42 (1992) 2125-2130
20. Di Sclafani V., Mackay R.D., Meyerhoff D.J., Norman D., Weiner M.W., and Fein G. Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment. J. Int. Neuropsychol. Soc. 3 (1997) 276-287
21. Dice L. Measures of the amount of ecologic association between species. Ecology 26 (1945) 297-302
22. Dunn L.M., and Dunn E.S. Peabody Picture Vocabulary Test-Third Edition (1997), American Guidance Service, Circle Pines, MN
23. Ernst T., Chang L., Witt M., Walot I., Aronow H., Leonido-Yee M., and Singer E. Progressive multifocal leukoencephalopathy and human immunodeficiency virus-associated white matter lesions in AIDS: magnetization transfer MR imaging. Radiology 210 (1999) 539-543
24. Fein G., Biggins C.A., and MacKay S. Alcohol abuse and HIV infection have additive effects on frontal cortex function as measured by auditory evoked potential P3a latency. Biol. Psychiatry 37 (1995) 183-195
25. Fein G., Di Sclafani V., Cardenas V.A., Goldmann H., Tolou-Shams M., and Meyerhoff D.J. Cortical gray matter loss in treatment-naive alcohol dependent individuals. Alcohol.: Clin. Exp. Res. 26 (2002) 558-564
26. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) Version 2.0 (1998), Biometrics Research Department, New York State Psychiatric Institute, New York, NY
27. Galvan F.H., Bing E.G., Fleishman J.A., London A.S., Caetano R., Burnam M.A., Longshore D., Morton S.C., Orlando M., and Shapiro M. The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: results from the HIV Cost and Services Utilization Study. J. Stud. Alcohol 63 (2002) 179-186
28. Gazdzinski S., Durazzo T.C., and Meyerhoff D.J. Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence. Drug Alcohol Depend. 78 (2005) 263-273
29. Gelman B.B., and Guinto F.C. Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodeficiency syndrome. Ann. Neurol. 32 (1992) 31-40
30. Goodkin K., Wilkie F.L., Concha M., Hinkin C.H., Symes S., Baldewicz T.T., Asthana D., Fujimura R.K., Lee D., van Zuilen M.H., Khamis I., Shapshak P., and Eisdorfer C. Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality. J. Clin. Epidemiol. 54 Suppl. 1 (2001) S35-S43
31. Green J.E., Saveanu R.V., and Bornstein R.A. The effect of previous alcohol abuse on cognitive function in HIV infection. Am. J. Psychiatry 161 (2004) 249-254
32. Heaton R.K., Grant I., Butters N., White D.A., Kirson D., Atkinson J.H., McCutchan J.A., Taylor M.J., Kelly M.D., Ellis R.J., Wolfson T., Velin R., Marcotte T.D., Hesselink J.R., Jernigan T.L., Chandler J., Wallace M., and Abramson I. The HNRC 500-neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. J. Int. Neuropsychol. Soc. 1 (1995) 231-251
33. Heindel W.C., Jernigan T.L., Archibald S.L., Achim C.L., Masliah E., and Wiley C.A. The relationship of quantitative brain magnetic resonance imaging measures to neuropathologic indexes of human immunodeficiency virus infection. Arch. Neurol. 51 (1994) 1129-1135
34. Hollingshead A., and Redlich F. Social Class and Mental Illness (1958), John Wiley and Sons, New York
35. Hommer D.W., Momenan R., Kaiser E., and Rawlings R.R. Evidence for a gender-related effect of alcoholism on brain volumes. Am. J. Psychiatry 158 (2001) 198-204
36. Jernigan T.L., Butters N., DiTraglia G., Schafer K., Smith T., Irwin M., Grant I., Schuckit M., and Cermak L. Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol.: Clin. Exp. Res. 15 (1991) 418-427
37. Jernigan T.L., Archibald S., Hesselink J.R., Atkinson J.H., Velin R.A., McCutchan J.A., Chandler J., and Grant I. Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection. The HNRC Group 50 (1993) 250-255
38. Karnofsky D.A. The clinical evaluation of chemotherapeutic agents in cancer. In: MacLeod C.M. (Ed). Evaluation of Chemotherapeutic Agents (1949), Columbia Univ. Press, New York 191-205
39. Langford T.D., Letendre S.L., Marcotte T.D., Ellis R.J., McCutchan J.A., Grant I., Mallory M.E., Hansen L.A., Archibald S., Jernigan T., and Masliah E. Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy. AIDS 16 (2002) 1019-1029
40. Lefevre F., O'Leary B., Moran M., Mossar M., Yarnold P.R., Martin G.J., and Glassroth J. Alcohol consumption among HIV-infected patients. J. Gen. Intern. Med. 10 (1995) 458-460
41. Lim K.O., and Pfefferbaum A. Segmentation of MR brain images into cerebrospinal fluid spaces, white and gray matter. J. Comput. Assist. Tomogr. 13 (1989) 588-593
42. Manji H., Connolly S., McAllister R., Valentine A.R., Kendall B.E., Fell M., Durrance P., Thompson A.J., Newman S., Weller I.V.D., and Harrison M.J.G. Serial MRI of the brain in asymptomatic patients infected with HIV: results from the UCMSM/Medical Research Council neurology cohort. J. Neurol., Neurosurg. Psychiatry 57 (1994) 144-149
43. Mankowski J.L., Queen S.E., Tarwater P.M., Fox K.J., and Perry V.H. Accumulation of beta-amyloid precursor protein in axons correlates with CNS expression of SIV gp41. J. Neuropathol. Exp. Neurol. 61 (2002) 85-90
44. Mann K., Gunther A., Stetter F., and Ackermann K. Rapid recovery from cognitive deficits in abstinent alcoholics: a controlled test-retest study. Alcohol Alcohol. 34 (1999) 567-574
45. Mann K.F., Ackermann K., Croissan B., Mundle G., and Diehl A. Neuroimaging of gender differences in alcoholism: are women more vulnerable?. Alcohol.: Clin. Exp. Res. 29 (2005) 896-901
46. McArthur J.C., Kumar A.J., Johnson D.W., Selnes O.A., Becker J.T., Herman C., Cohen B.A., and Saah A. Incidental white matter hyperintensities on magnetic resonance imaging in HIV-1 infection. J. Acquir. Immune Defic. Syndr. 3 (1990) 252-259
47. Meyerhoff D.J. Effects of alcohol and HIV infection on the central nervous system. Alcohol Res. Health 25 (2001) 288-298
48. Meyerhoff D.J., MacKay S., Sappey-Marinier D., Deicken R., Calabrese G., Dillon W.P., Weiner M.W., and Fein G. Effects of chronic alcohol abuse and HIV infection on brain phosphorus metabolites. Alcohol.: Clin. Exp. Res. 19 (1995) 685-692
49. Miguez M.J., Shor-Posner G., Morales G., Rodriguez A., and Burbano X. HIV treatment in drug abusers: impact of alcohol use. Addict. Biol. 8 (2003) 33-37
50. Navia B.A. Clinical and biologic features of the AIDS dementia complex. Neuroimaging Clin. N. Am. 7 (1997) 581-592
51. Navia B.A., Cho E.S., Petito C.K., and Price R.W. The AIDS dementia complex: II. Neuropathology. Ann. Neurol. 19 (1986) 525-535
52. Neuen-Jacob E., Arendt G., Wendtland B., Jacob B., Schneeweis M., and Wechsler W. Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions. Clin. Neuropathol. 12 (1993) 315-324
53. Olsen W.L., Longo F.M., Mills C.M., and Norman D. White matter disease in AIDS: findings at MR imaging. Radiology 169 (1988) 445-448
54. O'Neill J., Cardenas V.A., and Meyerhoff D.J. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol.: Clin. Exp. Res. 25 (2001) 1673-1682
55. Oscar-Berman M., and Hutner N. Frontal lobe changes after chronic alcohol ingestion. In: Hunt W.A., and Nixon S.J. (Eds). Alcohol-Induced Brain Damage. NIAAA Research Monographs vol. 22 (1993), National Institutes of Health, Rockville, MD 121-156
56. Page-Shafer K., Delorenze G.N., Satariano W.A., and Winkelstein Jr. W. Comorbidity and survival in HIV-infected men in the San Francisco Men's Health Survey. Annals of Epidemiology 6 (1996) 420-430
57. Paul R., Cohen R., Navia B., and Tashima K. Relationships between cognition and structural neuroimaging findings in adults with human immunodeficiency virus type-1. Neurosci. Biobehav. Rev. 26 (2002) 353-359
58. Paul R.H., Brickman A.M., Navia B., Hinkin C., Malloy P.F., Jefferson A.L., Cohen R.A., Tate D.F., and Flanigan T.P. Apathy is associated with volume of the nucleus accumbens in patients infected with HIV. Journal of Neuropsychiatry and Clin. Neurosci. 17 (2005) 167-171
59. Petry N.M. Alcohol use in HIV patients: what we don't know may hurt us. Int. J. STD AIDS 10 (1999) 561-570
60. Pfefferbaum A., and Sullivan E.V. Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn. Reson. Med. 49 (2003) 953-961
61. Pfefferbaum A., Lim K.O., Zipursky R.B., Mathalon D.H., Lane B., Ha C.N., Rosenbloom M.J., and Sullivan E.V. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol.: Clin. Exp. Res. 16 (1992) 1078-1089
62. Pfefferbaum A., Mathalon D.H., Sullivan E.V., Rawles J.M., Zipursky R.B., and Lim K.O. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch. Neurol. 51 (1994) 874-887
63. Pfefferbaum A., Sullivan E.V., Mathalon D.H., Shear P.K., Rosenbloom M.J., and Lim K.O. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol.: Clin. Exp. Res. 19 (1995) 1177-1191
64. Pfefferbaum A., Sullivan E.V., Mathalon D.H., and Lim K.O. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol.: Clin. Exp. Res. 21 (1997) 521-529
65. Pfefferbaum A., Sullivan E.V., Rosenbloom M.J., Mathalon D.H., and Lim K.O. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a five year interval. Arch. Gen. Psychiatry 55 (1998) 905-912
66. Pfefferbaum A., Rosenbloom M.J., Deshmukh A., and Sullivan E.V. Sex differences in the effects of alcohol on brain structure. Am. J. Psychiatry 158 (2001) 188-197
67. Pfefferbaum A., Rosenbloom M., and Sullivan E. Alcoholism and AIDS: MR imaging approaches for detecting interaction neuropathology. Alcohol.: Clin. Exp. Res. 26 (2002) 1031-1046
68. Pfefferbaum A., Adalsteinsson E., and Sullivan E.V. Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity. Neuropsychopharmacology 30 (2005) 1392-1399
69. Pfefferbaum A., Adalsteinsson E., and Sullivan E.V. Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol. Aging 27 (2006) 994-1009
70. Pfefferbaum A., Adalsteinsson E., and Sullivan E.V. Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women. Biol. Psychiatry 59 (2006) 364-372
71. Pfefferbaum, A., Rosenbloom, M.J., Adalsteinsson, E., Sullivan, E.V., in revision. Diffusion tensor imaging with quantitative fiber tracking in HIV infection and alcoholism comorbidity: Synergistic white matter damage.
72. Rohlfing T., and Maurer Jr. C.R. Nonrigid image registration in shared-memory multiprocessor environments with application to brains, breasts, and bees. IEEE Trans. Inf. Technol. Biomed. 7 (2003) 16-25
73. Rosenbloom, M.J., Sullivan, E.V., Sassoon, S.A., O'Reilly, A., Fama, R., Kemper, C.A., Pfefferbaum, A., in press. Alcoholism, HIV infection and their comorbidity: Factors affecting self-rated health-related quality of life. Journal of Studies on Alcoholism.
74. Rueckert D., Sonoda L.I., Hayes C., Hill D.L., Leach M.O., and Hawkes D.J. Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans. Med. Imaging 18 (1999) 712-721
75. Samet J.H., Horton N.J., Traphagen E.T., Lyon S.M., and Freedberg K.A. Alcohol consumption and HIV disease progression: are they related?. Alcohol.: Clin. Exp. Res. 27 (2003) 827-862
76. Samet J.H., Horton N.J., Meli S., Freedberg K.A., and Palepu A. Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcohol.: Clin. Exp. Res. 28 (2004) 572-577
77. Samet J.H., Phillips S.J., Horton N.J., Traphagen E.T., and Freedberg K.A. Detecting alcohol problems in HIV-infected patients: use of the CAGE questionnaire. AIDS Res. Hum. Retroviruses 20 (2004) 151-155
78. Schulte T., Pfefferbaum A., and Sullivan E.V. Parallel interhemispheric processing in aging and alcoholism: relation to corpus callosum size. Neuropsychologia 42 (2003) 257-271
79. Schulte T., Sullivan E.V., Müller-Oehring E.M., Adalsteinsson E., and Pfefferbaum A. Corpus callosal microstructural integrity influences interhemispheric processing: a diffusion tensor imaging study. Cereb. Cortex 15 (2005) 1384-1392
80. Schulte, T., Müller-Oehring, E.M., Pfefferbaum, A., Sullivan, E.V., in press. Callosal involvement in a lateralized Stroop task in alcoholic and healthy subjects. Neuropsychology.
81. Self R.L., Mulholland P.J., Harris B.R., Nath A., and Prendergast M.A. Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment. Alcohol.: Clin. Exp. Res. 28 (2004) 1916-1924
82. Shear P.K., Jernigan T.L., and Butters N. Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics. Alcohol.: Clin. Exp. Res. 18 (1994) 172-176
83. Skinner H.A. Development and Validation of a Lifetime Alcohol Consumption Assessment Procedure (1982), Addiction Research Foundation, Toronto, Canada
84. Skinner H.A., and Sheu W.J. Reliability of alcohol use indices: the lifetime drinking history and the MAST. J. Stud. Alcohol. 43 (1982) 1157-1170
85. Smith S. Fast robust automated brain extraction. Hum. Brain Mapp. 17 (2002) 143-155
86. Stein M., Herman D.S., Trisvan E., Pirraglia P., Engler P., and Anderson B.J. Alcohol use and sexual risk behavior among human immunodeficiency virus-positive persons. Alcohol.: Clin. Exp. Res. 29 (2005) 837-843
87. Stout J., Ellis R., Jernigan T., Archibald S., Abramson I., Wolfson T., McCutchan J., Wallace M., Atkinson J., and Grant I. Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. Arch. Neurol. 55 (1998) 161-168
88. Sullivan E.V., Pfefferbaum A., Adalsteinsson E., Swan G.E., and Carmelli D. Differential rates of regional change in callosal and ventricular size: a 4-year longitudinal MRI study of elderly men. Cereb. Cortex 12 (2002) 438-445
89. Sullivan E.V., Deshmukh A., De Rosa E., Rosenbloom M.J., and Pfefferbaum A. Striatal and forebrain nuclei volumes: contribution to motor function and working memory deficits in alcoholism. Biol. Psychiatry 57 (2005) 768-776
90. Supiot F., Guillaume M.P., Hermanus N., Telerman-Toppet N., and Karmali R. Toxoplasma encephalitis in a HIV patient: unusual involvement of the corpus callosum. Clin. Neurol. Neurosurg. 99 (1997) 287-290
91. Symonds L.L., Archibald S.L., Grant I., Zisook S., and Jernigan T.L. Does an increase in sulcal or ventricular fluid predict where brain tissue is lost?. J. Neuroimaging 9 (1999) 201-209
92. Tate D., Paul R.H., Flanigan T.P., Tashima K., Nash J., Adair C., Boland R., and Cohen R.A. The impact of apathy and depression on quality of life in patients infected with HIV. AIDS Patient Care STDS 17 (2003) 115-120
93. Thompson P.M., Dutton R.A., Hayashi K.M., Toga A.W., Lopez O.L., Aizenstein H.J., and Becker J.T. Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 15647-15652
94. Thompson P.M., Dutton R.A., Hayashi K.M., Lu A., Lee S.E., Lee J.Y., Lopez O.L., Aizenstein H.J., Toga A.W., and Becker J.T. 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. NeuroImage 15 (2006) 12-23
95. Thurnher M.M., Post M.J., Rieger A., Kleibl-Popov C., Loewe C., and Schindler E. Initial and follow-up MR imaging findings in AIDS-related progressive multifocal leukoencephalopathy treated with highly active antiretroviral therapy. Am. J. Neuroradiol. 22 (2001) 977-984
96. Wang Y., and Watson R.R. Is alcohol consumption a cofactor in the development of acquired immunodeficiency syndrome?. Alcohol 12 (1995) 105-109
97. Wang X., Douglas S.D., Metzger D.S., Guo C.J., Li Y., O'Brien C.P., Song L., Davis-Vogal A., and Ho W.Z. Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes. Alcohol.: Clin. Exp. Res. 26 (2002) 1880-1886
98. Wu P., Price P., Du B., Hatch W.C., and Terwilliger E.F. Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. NeuroReport 7 (1996) 1045-1049
99. Zijdenbos A.P., Dawant B.M., Margolin R.A., and Palmer A.C. Morphometric analysis of white matter lesions in MR images: method and validation. IEEE Trans. Med. Imaging 13 (1994) 716-724