Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes

Journal of NeuroVirology

Volumn 16, Issue 6, 2010, Pages 435-444

  Cohen, Ronald A ^a   Harezlak, Jaroslaw ^b   Gongvatana, Assawin ^a   Buchthal, Steven ^c   Schifitto, Giovanni ^d   Clark, Uraina ^a   Paul, Robert ^e   Taylor, Michael ^f   Thompson, Paul ^g   Tate, David ^h   Alger, Jeffery ^g   Brown, Mark ⁱ   Zhong, Jianhui ^d   Campbell, Thomas ⁱ   Singer, Elyse ^g   Daar, Eric ^g   McMahon, Deborah ^j   Tso, Yuen ^k   Yiannoutsos, Constantin T ^b   Navia, Bradford ^l  

^a BROWN UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HAWAII   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ UNIVERSITY OF COLORADO   (United States)

^j UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^k STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

brain; cerebral metabolites; cortical volume; HIV; magnetic resonance spectroscopy; morphometry; subcortical volume

Indexed keywords

CHOLINE; CREATINE; GLUTAMIC ACID; GLUTAMINE; N ACETYLASPARTIC ACID;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN SIZE; CAUDATE NUCLEUS; DEMENTIA; DISEASE ASSOCIATION; FEMALE; FRONTAL CORTEX; GRAY MATTER; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARIETAL LOBE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TEMPORAL LOBE; THALAMUS; WHITE MATTER;

ADULT; BASAL GANGLIA; CEREBRAL CORTEX; COHORT STUDIES; FEMALE; FRONTAL LOBE; HIV; HIV INFECTIONS; HUMANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; NEUROGLIA; THALAMUS;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 78649687236     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550284.2010.520817     Document Type: Article

References (47)

1. Akaike H (1974). A new look at the statistical model identification. IEEE Trans Autom Control 19: 716-723.
2. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007). Updated research nosology for HIV-associated neu-rocognitive disorders. Neurology 69: 1789-1799.
3. Aylward EH, Brettschneider PD, McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, Barta PE, Tien AY, Pearlson GD (1995). Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry 152: 987-994.
4. Antuono PG, Jones JL, Wang Y, Li SJ (2001). Decreased glutamate + glutamine in Alzheimer's disease detected in vivo with (1)H-MRS at 0.5 T. Neurology 56: 737-742.
5. Alemán-Gómez Y, Melie-García L, Valdés- Hernandez P (2006). IBASPM: toolbox for automatic parcellation of brain structures. Paper presented at Organization for Human Brain Mapping meeting; Florence, Italy; June 11-15, 2006.
6. Brew BJ (2004). Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS 18(Suppl 1): S75-S78.
7. Burnham KP, Anderson DR (2002). Model selection and multimodel inference: a practical-theoretic approach, 2nd ed. New York: Springer.
8. Broom KA, Anthony DC, Lowe JP, Griffin JL, Scott H, Blamire AM, Styles P, Perry VH, Sibson NR (2007). MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropatholog-ical and behavioural changes. Neurobiol Dis 26: 07-717.
9. Brew BJ, Crowe SM, Landay A, Cysique LA, Guillemin G. (2009). Neurodegeneration and ageing in the HAART era. J Neuroimmune Pharmacol 4: 163-174.
10. Binesh N, Huda A, Thomas MA, Wyckoff N, Bugbee M, Han S, Rasgon N, Davanzo P, Sayre J, Guze B, Martin P, Fawzy F (2006). Hepatic encephalopathy: a neurochem-ical, neuroanatomical, and neuropsychological study. J Appl Clin Med Phys 7: 86-96.
11. Brew BJ, Rosenblum M, Cronin K, Price RW (1995). AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Ann Neurol 38: 563-570.
12. Chang L, Ernst T, Leonido-Yee M, Walot I, Singer E (1999). Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex. Neurology 52: 100-108.
13. Chang L, Ernst T, Tornatore C, Aronow H, Melchor R, Walot I, Singer E, Cornford M (1997). Metabolite abnormalities in progressive multifocal leukoencephalopathy by proton magnetic resonance spectroscopy. Neurology 48: 836-845.
14. Chang L, Ernst T, Witt MD, Ames N, Gaiefsky M (2002). Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naive HIV patients. NeuroImage 17: 1638-1648.
15. Chang L, Ernst T, Witt MD, Ames N, Walot I, Jovicich J, DeSilva M, Trivedi N, Speck O, Miller EN (2003). Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART. Antivir Ther 8: 17-26.
16. Cohen RA, Harezlak J, Schifitto G, et al. (2010). Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era. J NeuroVirol 16: 25-32.
17. Chang L, Lee PL, Yiannoutsos CT, Ernst T, Marra CM, Richards T, Kolson D, Schifitto G, Jarvik JG, Miller EN, Lenkinski R, Gonzalez G, Navia BA (2004). A multicenter in vivo proton-MRS study of HIV-asso-ciated dementia and its relationship to age. NeuroImage 23: 1336-1347.
18. Gropman AL, Batshaw ML (2004). Cognitive outcome in urea cycle disorders. Mol Genet Metab 81(Suppl 1): S58-S62.
19. Gongvatana A, Schweinsburg BC, Taylor MJ, Theilmann RJ, Letendre SL, Alhassoon OM, Jacobus J, Woods SP, Jernigan TL, Ellis RJ, Frank LR, Grant I (2009). White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals. J NeuroVirol 15: 187-195.
20. Heindel WC, Jernigan TL, Archibald SL, Achim CL, Masliah E, Wiley CA (1994). The relationship of quantitative brain magnetic resonance imaging measures to neuropathologic indexes of human immunodeficiency virus infection. Arch Neurol 51: 1129-1135.
21. Jernigan TL, Archibald S, Hesselink JR, Atkinson JH, Velin RA, McCutchan JA, Chandler J, Grant I (1993). Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection. The HNRC Group. Arch Neurol 50: 250-255.
22. Jones RS, Waldman AD (2004). 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurol Res 26: 488-495.
23. Kreis R, Arcinue E, Ernst T, Shonk TK, Flores R, Ross BD (1996). Hypoxic encephalopathy after near-drowning studied by quantitative 1H-magnetic resonance spec-troscopy. J Clin Invest 97: 1142-1154.
24. Lentz MR, Kim WK, Lee V, Bazner S, Halpern EF, Venna N, Williams K, Rosenberg ES, Gonzalez RG (2009). Changes in MRS neuronal markers and T cell pheno-types observed during early HIV infection. Neurology 72: 1465-1472.
25. Long LL, Li XR, Huang ZK, Jiang YM, Fu SX, Zheng W (2009). Relationship between changes in brain MRI and (1)H-MRS, severity of chronic liver damage, and recovery after liver transplantation. Exp Biol Med (Maywood) 234: 1075-1085.
26. Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen LM, Meyerhoff DJ, Lenkinski RE, Gonzalez RG, Navia BA (2003). A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. J Magn Reson Imaging 17: 625-633.
27. McArthur JC (2004). HIV dementia: an evolving disease. J Neuroimmunol 157: 3-10.
28. Provencher SW (2001). Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 14: 260-264.
29. Paul RH, Ernst T, Brickman AM, Yiannoutsos CT, Tate DF, Cohen RA, Navia BA (2008). Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV. J Int Neu-ropsychol Soc 14: 725-733.
30. Patel SH, Inglese M, Glosser G, Kolson DL, Grossman RI, Gonen O (2003). Whole-brain N-acetylaspartate level and cognitive performance in HIV infection. AJNR Am J Neuroradiol 24: 1587-1591.
31. Paul RH, Yiannoutsos CT, Miller EN, Chang L, Marra CM, Schifitto G, Ernst T, Singer E, Richards T, Jarvik GJ, Price R, Meyerhoff DJ, Kolson D, Ellis RJ, Gonzalez G, Lenkinski RE, Cohen RA, Navia BA (2007). Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. J Neuropsychiatry Clin Neurosci 19: 283-292.
32. Ross B, Bluml S (2001). Magnetic resonance spectroscopy of the human brain. Anat Rec 265: 54-84.
33. Ratai EM, Pilkenton SJ, Greco JB, Lentz MR, Bombardier JP, Turk KW, He J, Joo CG, Lee V, Westmoreland S, Halpern E, Lackner AA, Gonzalez RG (2009). In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci 10: 63.
34. Sijens PE, Alkefaji H, Lunsing RJ, van Spronsen FJ, Meiners LC, Oudkerk M, Verkade HJ (2008). Quantitative multivoxel 1H MR spectroscopy of the brain in children with acute liver failure. Eur Radiol 18: 2601-2609.
35. Sacktor N, McDermott MP, Marder K, Schifitto G, Selnes OA, McArthur JC, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida JA, Cohen B, Epstein L (2002). HIV-associated cognitive impairment before and after the advent of combination therapy. J NeuroVirol 8: 136-142.
36. Sacktor N, Skolasky RL, Ernst T, Mao X, Selnes O, Pomper MG, Chang L, Zhong K, Shungu DC, Marder K, Shibata D, Schifitto G, Bobo L, Barker PB (2005). A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. J Magn Reson Imaging 21: 325-333.
37. Schweinsburg BC, Taylor MJ, Alhassoon OM, Gonzalez R, Brown GG, Ellis RJ, Letendre S, Videen JS, McCutchan JA, Patterson TL, Grant I (2005). Brain mitochondrial injury in human immunodeficiency vir-us-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors. J NeuroVirol 11: 356-364.
38. Schifitto G, Yiannoutsos CT, Ernst T, Navia BA, Nath A, Sacktor N, Anderson C, Marra CM, Clifford DB (2009a). Selegiline and oxidative stress in HIV-associated cognitive impairment. Neurology 73: 1975-1981.
39. Schifitto G, Zhong J, Gill D, Peterson DR, Gaugh MD, Zhu T, Tivarus M, Cruttenden K, Maggirwar SB, Gendelman HE, Dewhurst S, Gelbard HA (2009b). Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment. J NeuroVirol 15: 176-186.
40. Thompson PM, Dutton RA, Hayashi KM, Toga AW, Lopez OL, Aizenstein HJ, Becker JT (2005). Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc Natl Acad Sci USA 102: 15647-15652.
41. Tkac I, Dubinsky JM, Keene CD, Gruetter R, Low WC (2007). Neurochemical changes in Huntington R6/ 2 mouse striatum detected by in vivo 1H NMR spec-troscopy. J Neurochem 100: 1397-1406.
42. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 15: 273-289.
43. Tate D, Harezlak J, Price J, Dewey J, Yiannoutsos C, Campbell T, Daar E, McMahon D, Schifitto G, Zhong J, Taylor M Singer E, Alger J, Brown M, Cohen R, Navia B (2010). Progressive brain atrophy in chronic HIV infection: longitudinal analysis of the HIVNC Cohort Study. Human Brain Mapping. Barcelona, Spain; June 6-10, 2010.
44. Tarasow E, Wiercinska-Drapalo A, Kubas B, Dzienis W, Orzechowska- Bobkiewicz A, Prokopowicz D, Walecki J (2003). Cerebral MR spectroscopy in neurologically asymptomatic HIV-infected patients. Acta Radiol 44: 206-212.
45. Valcour V, Sacktor N (2002). HIV-associated dementia and aging. J Ment Health Aging 8: 295-306.
46. Valcour V, Shikuma C, Waters M, Sacktor N (2004). Cognitive impairment in older HIV-1 seropositive individuals: prevalence and potential mechanisms. AIDS 18(Suppl 1): S79-S86.
47. Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM, Meyerhoff DJ, Jarvik JG, Kolson D, Schifitto G, Ellis RJ, Swindells S, Simpson DM, Miller EN, Gonzalez RG, Navia BA (2004). Regional patterns of brain metabolites in AIDS dementia complex. NeuroImage 23: 928-935.