Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: Insight from molecular dynamics

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Kikuchi, Hiroto ^a   Fujisaki, Hiroshi ^a,c   Furuta, Tadaomi ^b,c   Okamoto, Ken ^a   Leimkühler, Silke ^d,e   Nishino, Takeshi ^a,d,f  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c RIKEN   (Japan)

^d UNIVERSITY OF POTSDAM   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FEBUXOSTAT; THIAZOLE DERIVATIVE; XANTHINE DEHYDROGENASE;

ANIMAL; ARTICLE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; MOLECULAR DYNAMICS; RHODOBACTER CAPSULATUS;

ANIMALS; CATTLE; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; RHODOBACTER CAPSULATUS; THIAZOLES; XANTHINE DEHYDROGENASE;

EID: 84859747169     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00331     Document Type: Article

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