An essential regulatory role of downstream of kinase-1 in the ovalbumin-induced murine model of asthma

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Lee, Chang Min ^a   Jung, In Duk ^a   Noh, Kyung Tae ^a   Lee, Jun Sik ^b   Park, Jin Wook ^a   Heo, Deok Rim ^a   Park, Jun Ho ^c,d   Chang, Jeong Hyun ^e   Choi, Il Whan ^f   Kim, Jong Suk ^g   Shin, Yong Kyoo ^h   Park, Sung Joo ⁱ   Han, Myung Kwan ^g   Lee, Chun Geun ^j   Cho, Won Kyung ^j   Park, Yeong Min ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Chosun University   (South Korea)

^c Busan Medical Center   (South Korea)

^d Daegu Haany University ^*

^e Daegu Haany University   (South Korea)

^f Inje University College of Medicine   (South Korea)

^g Chonbuk National University Medical School   (South Korea)

^h Chung Ang University College of Medicine   (South Korea)

ⁱ Wonkwang University   (South Korea)

^j YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; COMPLEMENTARY DNA; KINASE 1; LENTIVIRUS VECTOR; OVALBUMIN; PHOSPHOTRANSFERASE; SHORT HAIRPIN RNA; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DOK1 PROTEIN, MOUSE; PHOSPHOPROTEIN; RNA BINDING PROTEIN; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL NUCLEUS; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIUM CELL; FEMALE; GENE SILENCING; INFLAMMATORY CELL; INTRACELLULAR TRANSPORT; MOUSE; MUCUS SECRETION; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH2 CELL; ANIMAL; CHEMICALLY INDUCED DISORDER; GENETICS; LENTIVIRINAE; METABOLISM;

MURINAE; MUS;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; LENTIVIRUS; MICE; OVALBUMIN; PHOSPHOPROTEINS; RNA-BINDING PROTEINS; STAT4 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS;

EID: 84859720189     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034554     Document Type: Article

References (44)

1. Elias JA, Zhu Z, Chupp G, Homer RJ, (1999) Airway remodeling in asthma. J Clin Invest 104: 1001-1006.
2. Choi JR, Lee CM, Jung ID, Lee JS, Jeong YI, et al. (2009) Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. Int Immunopharmacol 9: 918-924.
3. Vogel G, (2002) Asthma research. Missing gene takes mice's breath away. Science 295: 253.
4. Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, et al. (2007) A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 357: 2016-2027.
5. Jeon SG, Oh SY, Park HK, Kim YS, Shim EJ, et al. (2007) TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. J Allergy Clin Immunol 120: 803-812.
6. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, et al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263.
7. Kurowska-Stolarska M, Kewin P, Murphy G, Russo RC, Stolarski B, et al. (2008) IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol 181: 4780-4790.
8. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, et al. (2004) Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 10: 1095-1103.
9. Zhou M, Ouyang W, (2003) The function role of GATA-3 in Th1 and Th2 differentiation. Immunol Res 28: 25-37.
10. Darcan-Nicolaisen Y, Meinicke H, Fels G, Hegend O, Haberland A, et al. (2009) Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice. J Immunol 182: 7501-7508.
11. Hirota JA, Ask K, Fritz D, Ellis R, Wattie J, et al. (2009) Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study. Clin Exp Allergy 39: 147-158.
12. Tamachi T, Takatori H, Fujiwara M, Hirose K, Maezawa Y, et al. (2009) STAT6 inhibits T-bet-independent Th1 cell differentiation. Biochem Biophys Res Commun 382: 751-755.
13. Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, et al. (2007) Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. J Immunol 178: 6191-6199.
14. Pernis AB, Rothman PB, (2002) JAK-STAT signaling in asthma. J Clin Invest 109: 1279-1283.
15. Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, et al. (2007) D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett 581: 57-64.
16. Hirahara K, Yamashita M, Iwamura C, Shinoda K, Hasegawa A, et al. (2008) Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J Allergy Clin Immunol 122: 512-520 e511.
17. Lee CC, Huang HY, Chiang BL, (2008) Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol Ther 16: 60-65.
18. Das J, Chen CH, Yang L, Cohn L, Ray P, et al. (2001) A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2: 45-50.
19. Mashima R, Hishida Y, Tezuka T, Yamanashi Y, (2009) The roles of Dok family adapters in immunoreceptor signaling. Immunol Rev 232: 273-285.
20. Niki M, Di Cristofano A, Zhao M, Honda H, Hirai H, et al. (2004) Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med 200: 1689-1695.
21. Inoue A, Yasuda T, Yamamoto T, Yamanashi Y, (2007) Dok-1 is a positive regulator of IL-4 signalling and IgE response. J Biochem 142: 257-263.
22. Hiragun T, Peng Z, Beaven MA, (2005) Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Mol Pharmacol 67: 598-603.
23. Itoh S, Lemay S, Osawa M, Che W, Duan Y, et al. (2005) Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem 280: 26383-26396.
24. Dong S, Corre B, Foulon E, Dufour E, Veillette A, et al. (2006) T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J Exp Med 203: 2509-2518.
25. Wu L, Bijian K, Shen SS, (2009) CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells. Mol Immunol 46: 2167-2177.
26. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, et al. (2005) Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med 201: 333-339.
27. Mancardi DA, Iannascoli B, Hoos S, England P, Daeron M, et al. (2008) FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest 118: 3738-3750.
28. Marshall E, (2001) Clinical research. Procedures faulted in fatal asthma trial. Science 293: 405-407.
29. Richardson PJ, (1997) Asthma. Blocking adenosine with antisense. Nature 385: 684-685.
30. Kim D, Kim SH, Park EJ, Kang CY, Cho SH, et al. (2009) Anti-allergic effects of PG102, a water-soluble extract prepared from Actinidia arguta, in a murine ovalbumin-induced asthma model. Clin Exp Allergy 39: 280-289.
31. Kim SH, Park HJ, Lee CM, Choi IW, Moon DO, et al. (2006) Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma. FEBS Lett 580: 1883-1890.
32. Sokol CL, Barton GM, Farr AG, Medzhitov R, (2008) A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9: 310-318.
33. Abbott A, (2004) Beta-blocker goes on trial as asthma therapy. Nature 432: 7.
34. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, et al. (2003) New insights into the pathogenesis of asthma. J Clin Invest 111: 291-297.
35. Koch M, Witzenrath M, Reuter C, Herma M, Schutte H, et al. (2006) Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation. Am J Respir Cell Mol Biol 35: 211-219.
36. Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, et al. (2008) Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest 118: 2771-2784.
37. Barnes PJ, (2008) The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 118: 3546-3556.
38. Holgate ST, (1999) The epidemic of allergy and asthma. Nature 402: B2-4.
39. Shinohara H, Yasuda T, Yamanashi Y, (2004) Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells 9: 601-607.
40. Lee PJ, Zhang X, Shan P, Ma B, Lee CG, et al. (2006) ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest 116: 163-173.
41. Mullings RE, Wilson SJ, Puddicombe SM, Lordan JL, Bucchieri F, et al. (2001) Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol 108: 832-838.
42. Held HD, Uhlig S, (2000) Basal lung mechanics and airway and pulmonary vascular responsiveness in different inbred mouse strains. J Appl Physiol 88: 2192-2198.
43. Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, et al. (2006) Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A 103: 11021-11026.
44. Nikolaidis NM, Wang TC, Hogan SP, Rothenberg ME, (2006) Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung. Exp Lung Res 32: 483-497.