-
1
-
-
11144341956
-
Chemical space and biology
-
DOI 10.1038/nature03192
-
Dobson, C. M. Chemical space and biology Nature 2004, 432, 824-828 (Pubitemid 40037137)
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 824-828
-
-
Dobson, C.M.1
-
2
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stokwell, B. R. Exploring biology with small organic molecules Nature 2004, 432, 846-854
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stokwell, B.R.1
-
3
-
-
33644846857
-
Small molecules: The missing link in the central dogma
-
Schreiber, S. L. Small molecules: the missing link in the central dogma Nat. Chem. Biol. 2005, 1, 64-66
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 64-66
-
-
Schreiber, S.L.1
-
4
-
-
0142147275
-
Generating Diverse Skeletons of Small Molecules Combinatorially
-
DOI 10.1126/science.1089946
-
Burke, M. D.; Berger, E. M.; Schreiber, S. L. Generating diverse skeletons of small molecules combinatorially Science 2003, 302, 613-618 (Pubitemid 37310911)
-
(2003)
Science
, vol.302
, Issue.5645
, pp. 613-618
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
5
-
-
78649254350
-
Grand challenge commentary: Accessing new chemical space for "undruggable" targets
-
Marcaurelle, L. A.; Dandapani, S. Grand challenge commentary: Accessing new chemical space for "undruggable" targets Nat. Chem. Biol. 2010, 6, 861-863
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 861-863
-
-
Marcaurelle, L.A.1
Dandapani, S.2
-
6
-
-
84880296641
-
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
-
Galloway, W. R. J. D.; Isidro-Llobet, A.; Spring, D. R. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules Nature Commun. 2010, 1, 80
-
(2010)
Nature Commun.
, vol.1
, pp. 80
-
-
Galloway, W.R.J.D.1
Isidro-Llobet, A.2
Spring, D.R.3
-
7
-
-
79955563790
-
Organic synthesis toward small-molecule probes and drugs
-
Schreiber, S. L. Organic synthesis toward small-molecule probes and drugs Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6699-6702
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 6699-6702
-
-
Schreiber, S.L.1
-
8
-
-
34250673184
-
An approach to skeletal diversity using functional group pairing of multifunctional scaffolds
-
Comer, E.; Rohan, E.; Deng., L.; Porco, J. A., Jr. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds Org. Lett. 2007, 9, 2123-2126
-
(2007)
Org. Lett.
, vol.9
, pp. 2123-2126
-
-
Comer, E.1
Rohan, E.2
Deng, L.3
Porco Jr., J.A.4
-
9
-
-
3042799070
-
A planning strategy for diversity-oriented synthesis
-
Burke, M. D.; Schreiber, S. L. A planning strategy for diversity-oriented synthesis Angew. Chem., Int. Ed. 2004, 43, 46-59
-
(2004)
Angew. Chem., Int. Ed.
, vol.43
, pp. 46-59
-
-
Burke, M.D.1
Schreiber, S.L.2
-
10
-
-
29844455070
-
Small-molecule diversity using a skeletal transformation strategy
-
DOI 10.1021/ol0504345
-
Kumar, N.; Kiuchi, M.; Tallarico, J. A.; Schreiber, S. L. Small-molecule diversity using skeletal transformation strategy Org. Lett. 2005, 7, 2535-2538 (Pubitemid 43034202)
-
(2005)
Organic Letters
, vol.7
, Issue.13
, pp. 2535-2538
-
-
Kumar, N.1
Kiuchi, M.2
Tallarico, J.A.3
Schreiber, S.L.4
-
11
-
-
33845208398
-
An oligomer-based approach to skeletal diversity in small-molecule synthesis
-
DOI 10.1021/ja065724a
-
Spiegel, D. A.; Schroeder, F. C.; Duvall, J. R.; Schreiber, S. L. An oligomer-based approach to skeletal diversity in small-molecule synthesis J. Am. Chem. Soc. 2006, 128, 14766-14767 (Pubitemid 44851590)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.46
, pp. 14766-14767
-
-
Spiegel, D.A.1
Schroeder, F.C.2
Duvall, J.R.3
Schreiber, S.L.4
-
12
-
-
41149097628
-
Diversity-oriented synthesis; A spectrum of approaches and results
-
DOI 10.1039/b719372f
-
Spandl, R. J.; Bender, A.; Spring, D. R. Diversity-oriented synthesis; a spectrum of approaches and results Org. Biomol. Chem. 2008, 6, 1149-1158 (Pubitemid 351432832)
-
(2008)
Organic and Biomolecular Chemistry
, vol.6
, Issue.7
, pp. 1149-1158
-
-
Spandl, R.J.1
Bender, A.2
Spring, D.R.3
-
13
-
-
37549020046
-
Towards the optimal screening collection: A synthesis strategy
-
Nielsen, T. E.; Schreiber, S. L. Towards the optimal screening collection: a synthesis strategy Angew. Chem., Int. Ed. 2008, 47, 48-56
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 48-56
-
-
Nielsen, T.E.1
Schreiber, S.L.2
-
14
-
-
58149346448
-
Synthesis of natural product-like molecules with over eighty distinct skeletons
-
Morton, D.; Leach, S.; Cordier, C.; Warriner, S.; Nelson, A. Synthesis of natural product-like molecules with over eighty distinct skeletons Angew. Chem., Int. Ed. 2009, 48, 104-109
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 104-109
-
-
Morton, D.1
Leach, S.2
Cordier, C.3
Warriner, S.4
Nelson, A.5
-
15
-
-
67849083142
-
Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy
-
Luo, T.; Schreiber, S. L. Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy J. Am. Chem. Soc. 2009, 131, 5667-5674
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 5667-5674
-
-
Luo, T.1
Schreiber, S.L.2
-
16
-
-
79955566051
-
Route to three-dimensional fragments using diversity-oriented synthesis
-
Hung, A. W.; Ramek, A.; Wang, Y.; Kaya, T.; Wilson, A. J.; Clemons, P. A.; Young, D. W. A. Route to three-dimensional fragments using diversity-oriented synthesis Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6799-6804
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 6799-6804
-
-
Hung, A.W.1
Ramek, A.2
Wang, Y.3
Kaya, T.4
Wilson, A.J.5
Clemons, P.A.6
Young, D.W.A.7
-
17
-
-
78649527328
-
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: Discovery of macrocyclic histone deacetylase inhibitors
-
Marcaurelle, L. A.; Comer, E.; Dandapani, S.; Duvall, J. R.; Baudouin, G.; Kesavan, S.; Lee, M. D.; Liu, H.; Lowe, J. T.; Marie, J.-C.; Mulrooney, C. A.; Pandya, B. A.; Rowley, A.; Ryba, T. D.; Suh, B.-C.; Wei, J.; Young, D. W.; Akella, L. B.; Ross, N. T.; Zhang, Y.-L.; Fass, D. M.; Reis, S. A.; Zhao, W.-N.; Haggarty, S. J.; Palmer, M.; Foley, M. A. An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors J. Am. Chem. Soc. 2010, 132, 16962-16976
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 16962-16976
-
-
Marcaurelle, L.A.1
Comer, E.2
Dandapani, S.3
Duvall, J.R.4
Baudouin, G.5
Kesavan, S.6
Lee, M.D.7
Liu, H.8
Lowe, J.T.9
Marie, J.-C.10
Mulrooney, C.A.11
Pandya, B.A.12
Rowley, A.13
Ryba, T.D.14
Suh, B.-C.15
Wei, J.16
Young, D.W.17
Akella, L.B.18
Ross, N.T.19
Zhang, Y.-L.20
Fass, D.M.21
Reis, S.A.22
Zhao, W.-N.23
Haggarty, S.J.24
Palmer, M.25
Foley, M.A.26
more..
-
18
-
-
78449286975
-
Expanding stereochemical and skeletal diversity using Petasis reactions and 1,3-dipolar cycloadditions
-
Muncipinto, G.; Kaya, T.; Wilson, A. J.; Kumagai, N.; Clemons, P. A.; Schreiber, S. L. Expanding stereochemical and skeletal diversity using Petasis reactions and 1,3-dipolar cycloadditions Org. Lett. 2010, 12, 5230-5233
-
(2010)
Org. Lett.
, vol.12
, pp. 5230-5233
-
-
Muncipinto, G.1
Kaya, T.2
Wilson, A.J.3
Kumagai, N.4
Clemons, P.A.5
Schreiber, S.L.6
-
19
-
-
0027454702
-
The boronic acid Mannich reaction: A new method for the synthesis of geometrically pure allylamines
-
DOI 10.1016/S0040-4039(00)61625-8
-
Petasis, N. A.; Akritopoulou, I. The boronic-acid Mannich reaction: A new method for the synthesis of geometrically pure allylamines Tetrahedron Lett. 1993, 34, 583-586 (Pubitemid 23034547)
-
(1993)
Tetrahedron Letters
, vol.34
, Issue.4
, pp. 583-586
-
-
Petasis, N.A.1
Akritopoulou, I.2
-
20
-
-
0002924629
-
Asymmetry in the boronic acid Mannich reaction: Diastereocontrolled addition to chiral iminium species derived from aldehydes and (S)-5-phenylmorpholin-2-one
-
Harwood, L. M.; Currie, G. S.; Drew, M. G. B.; Luke, R. W. A. Asymmetry in the boronic acid Mannich reaction: Diastereocontrolled addition to chiral iminium species derived from aldehydes and (S)-5-phenylmorpholin-2-one Chem. Commun. 1996, 1953-1954 (Pubitemid 126424380)
-
(1996)
Chemical Communications
, Issue.16
, pp. 1953-1954
-
-
Harwood, L.M.1
Currie, G.S.2
Drew, M.G.B.3
Luke, R.W.A.4
-
21
-
-
0030821811
-
Amino acid derivatives by multicomponent reactions
-
Dyker, G. Amino acid derivatives by multicomponent reactions Angew. Chem., Int. Ed. 1997, 36, 1700-1702
-
(1997)
Angew. Chem., Int. Ed.
, vol.36
, pp. 1700-1702
-
-
Dyker, G.1
-
22
-
-
77958034343
-
Boronic acid and esters in the Petasis-borono Mannich multicomponent reaction
-
For a review on the Petasis 3-CR, see: Candeias, N. R.; Montalbano, F.; Cal, P. M. S. D.; Gois, P. M. P. Boronic acid and esters in the Petasis-borono Mannich multicomponent reaction Chem. Rev. 2010, 110, 6169-6193
-
(2010)
Chem. Rev.
, vol.110
, pp. 6169-6193
-
-
Candeias, N.R.1
Montalbano, F.2
Cal, P.M.S.D.3
Gois, P.M.P.4
-
23
-
-
36049015039
-
Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions
-
Kumagai, N.; Muncipinto, G.; Schreiber, S. L. Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions Angew. Chem., Int. Ed. 2006, 118, 3717-3720
-
(2006)
Angew. Chem., Int. Ed.
, vol.118
, pp. 3717-3720
-
-
Kumagai, N.1
Muncipinto, G.2
Schreiber, S.L.3
-
24
-
-
80051747274
-
Catalytic diastereoselective Petasis reactions
-
The applicability of the Petasis 3-CR in B/C/P pathways is further merited by a recent report on the syn-selective variant of the reaction: Muncipinto, G.; Moquist, P. N.; Schreiber, S. L.; Schaus, S. E. Catalytic diastereoselective Petasis reactions Angew. Chem., Int. Ed. 2011, 50, 8172-8175
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 8172-8175
-
-
Muncipinto, G.1
Moquist, P.N.2
Schreiber, S.L.3
Schaus, S.E.4
-
25
-
-
77949595728
-
Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts
-
For a recent review on metathesis, see: Vougioukalakis, G. C.; Grubbs, R. H. Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts Chem. Rev. 2010, 110, 1746-1787
-
(2010)
Chem. Rev.
, vol.110
, pp. 1746-1787
-
-
Vougioukalakis, G.C.1
Grubbs, R.H.2
-
26
-
-
79956115514
-
Synthesis of heterocycles through a ruthenium-catalyzed tandem ring-closing metathesis/isomerization/ N -acyliminium cyclization sequence
-
Ascic, E.; Jensen, J. F.; Nielsen, T. E. Synthesis of heterocycles through a ruthenium-catalyzed tandem ring-closing metathesis/isomerization/ N -acyliminium cyclization sequence Angew. Chem., Int. Ed. 2011, 50, 5188-5191
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 5188-5191
-
-
Ascic, E.1
Jensen, J.F.2
Nielsen, T.E.3
-
27
-
-
14644412877
-
Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: A pyrrolidine-derived arylglycine synthesis
-
DOI 10.1016/j.tetlet.2005.01.151
-
Nanda, K. K.; Trotter, B. W. Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: A pyrrolidine-derived arylglycine synthesis Tetrahedron Lett. 2005, 46, 2025-2028 (Pubitemid 40311220)
-
(2005)
Tetrahedron Letters
, vol.46
, Issue.12
, pp. 2025-2028
-
-
Nanda, K.K.1
Trotter, B.W.2
-
28
-
-
0001128282
-
Enantioselective Synthesis of α-hydroxy acids employing (1 S)-(+)- N,N- diisopropyl-10-camphorsulfonamide as chiral auxiliary
-
references herein
-
Chang, J.-W.; Jang, D.-P.; Uang, B.-J.; Liao, F.-L.; Wang, S.-L. Enantioselective Synthesis of α-hydroxy acids employing (1 S)-(+)- N,N- diisopropyl-10-camphorsulfonamide as chiral auxiliary Org. Lett. 1999, 13, 2061-2063 and references herein.
-
(1999)
Org. Lett.
, vol.13
, pp. 2061-2063
-
-
Chang, J.-W.1
Jang, D.-P.2
Uang, B.-J.3
Liao, F.-L.4
Wang, S.-L.5
-
29
-
-
0037150417
-
Indium-mediated diastereoselective allylation reactions: Preparation of α-hydroxy and α-amino acids
-
Lee, J.-G.; Choi, K.-I.; Pae, A.-N.; Koh, H.-Y.; Kang, Y.; Cho, Y.-S. Indium-mediated diastereoselective allylation reactions: preparation of α-hydroxy and α-amino acids J. Chem. Soc., Perkin Trans. 2002, 1, 1314-1317 and references herein. (Pubitemid 34630722)
-
(2002)
Journal of the Chemical Society. Perkin Transactions 1
, Issue.10
, pp. 1314-1317
-
-
Lee, J.G.1
Choi, K.I.2
Pae, A.N.3
Koh, H.Y.4
Kang, Y.5
Cho, Y.S.6
-
30
-
-
15044355873
-
Lewis acid assisted ring-closing metathesis of chiral diallylamines: An efficient approach to enantiopure pyrrolidine derivatives
-
DOI 10.1021/ol047356q
-
Yiang, Q.; Xiao, W.; Yu, Z. Lewis acid assisted ring-closing metathesis of chiral diallylamines: An efficient approach to enantiopure pyrrolidine derivatives Org. Lett. 2005, 7, 871-874 (Pubitemid 40380247)
-
(2005)
Organic Letters
, vol.7
, Issue.5
, pp. 871-874
-
-
Yang, Q.1
Xiao, W.-J.2
Yu, Z.3
-
31
-
-
79959236946
-
Palladium-catalyzed ring-contraction and ring-expansion reactions of cyclic allyl amines
-
Dubovyk, I.; Pichugin, D.; Yudin, A. K. Palladium-catalyzed ring-contraction and ring-expansion reactions of cyclic allyl amines Angew. Chem., Int. Ed. 2011, 50, 5924-5926
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 5924-5926
-
-
Dubovyk, I.1
Pichugin, D.2
Yudin, A.K.3
-
32
-
-
0037073212
-
New tandem catalysis: Preparation of cyclic enol ethers through a ruthenium-catalyzed ring-closing metathesis-olefin isomerization sequence
-
DOI 10.1021/ja028044q
-
Sutton, A. E.; Seigal, B. A.; Finnegan, D. F.; Snapper, M. L. New tandem catalysis: preparation of cyclic enol ethers through a ruthenium-catalyzed ring-closing metathesis-olefin isomerization sequence J. Am. Chem. Soc. 2002, 124, 13390-13391 (Pubitemid 35285909)
-
(2002)
Journal of the American Chemical Society
, vol.124
, Issue.45
, pp. 13390-13391
-
-
Sutton, A.E.1
Seigal, B.A.2
Finnegan, D.F.3
Snapper, M.L.4
-
33
-
-
15444363138
-
Synthesis of polycyclic lactams and sultams by a cascade ring-closure metathesis/isomerization and subsequent radical cyclization
-
DOI 10.1055/s-2005-862386, D35104ST
-
Bressy, C.; Menant, C.; Piva, O. Synthesis of polycyclic lactams and sultams by a cascade ring-closure metathesis/isomerization and subsequent radical cyclization Synlett 2005, 577-582 (Pubitemid 40395551)
-
(2005)
Synlett
, Issue.4
, pp. 577-582
-
-
Bressy, C.1
Menant, C.2
Piva, O.3
-
34
-
-
6344226411
-
Ruthenium-catalyzed olefin metathesis double-bond isomerization sequence
-
DOI 10.1021/jo048937w
-
Schmidt, B. Ruthenium-catalyzed olefin metathesis double-bond isomerization sequence J. Org. Chem. 2004, 69, 7672-7687 (Pubitemid 39403355)
-
(2004)
Journal of Organic Chemistry
, vol.69
, Issue.22
, pp. 7672-7687
-
-
Schmidt, B.1
-
35
-
-
38349172460
-
Tandem RCM-isomerization approach to glycals of desoxyheptoses from a common precursor
-
Schmidt, B.; Biernat, A. Tandem RCM-isomerization approach to glycals of desoxyheptoses from a common precursor Org. Lett. 2008, 10, 105-108
-
(2008)
Org. Lett.
, vol.10
, pp. 105-108
-
-
Schmidt, B.1
Biernat, A.2
-
36
-
-
68949158621
-
Grubbs ruthenium-carbenes beyond the metathesis reaction: Less conventional non-metathetic utility
-
Alcaide, B.; Almendros, P.; Luna, A. Grubbs ruthenium-carbenes beyond the metathesis reaction: less conventional non-metathetic utility Chem. Rev. 2009, 109, 3817-3858
-
(2009)
Chem. Rev.
, vol.109
, pp. 3817-3858
-
-
Alcaide, B.1
Almendros, P.2
Luna, A.3
-
37
-
-
0037451439
-
Non-metathetic behavior patterns of Grubbs carbene
-
Alcaide, B.; Almendros, P. Non-metathetic behavior patterns of Grubbs carbene Chem. - Eur. J. 2003, 9, 1258-1262
-
(2003)
Chem. - Eur. J.
, vol.9
, pp. 1258-1262
-
-
Alcaide, B.1
Almendros, P.2
-
38
-
-
55549105103
-
Relay catalysis by a metal-complex/Brønsted acid binary system in a tandem isomerization/carbon-carbon bond forming sequence
-
Sorimachi, K.; Terada, M. Relay catalysis by a metal-complex/ Brønsted acid binary system in a tandem isomerization/carbon-carbon bond forming sequence J. Am. Chem. Soc. 2008, 130, 14452-14453
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 14452-14453
-
-
Sorimachi, K.1
Terada, M.2
-
39
-
-
33645977761
-
Stereoselective synthesis of 2-hydroxymorpholines and amino diols via a three-component boro-Mannich reaction
-
Berrée, F.; Debache, A.; Marac, Y.; Collet, B.; Girard-Le Bleiz, P.; Carboni, B. Stereoselective synthesis of 2-hydroxymorpholines and amino diols via a three-component boro-Mannich reaction Tetrahedron 2006, 62, 4027-4037
-
(2006)
Tetrahedron
, vol.62
, pp. 4027-4037
-
-
Berrée, F.1
Debache, A.2
Marac, Y.3
Collet, B.4
Girard-Le Bleiz, P.5
Carboni, B.6
|