Genistein attenuated allergic airway inflammation by modulating the transcription factors T-bet, GATA-3 and STAT-6 in a murine model of asthma

Pharmacology

Volumn 89, Issue 3-4, 2012, Pages 229-236

  Gao, Fei ^a   Wei, Dong ^a   Bian, Tao ^a   Xie, Ping ^a   Zou, Jian ^a   Mu, Huijun ^a   Zhang, Bin ^a   Zhou, Xiaoyan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Asthma; Cytokine; Genistein; Transcription factor

Indexed keywords

GAMMA INTERFERON; GENISTEIN; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL;

ALLERGENS; ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; GATA3 TRANSCRIPTION FACTOR; GENISTEIN; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; RNA, MESSENGER; STAT6 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS;

EID: 84859714760     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000337180     Document Type: Article

References (29)

1. Finn PW, Bigby TD: Innate immunity and asthma. Proc Am Thorac Soc 2009; 6: 260-265.
2. Cohn L, Elias JA, Chupp GL: Asthma: Mechanisms of disease persistence and progression. Annu Rev Immunol 2004; 22: 789-815. (Pubitemid 38680442)
3. Robinson DS: The role of the T cell in asthma. J Allergy Clin Immunol 2010; 126: 1081-1091, 1092-1093.
4. Finiasz M, Otero C, Bezrodnik L, Fink S: The role of cytokines in atopic asthma. Curr Med Chem 2011; 18: 1476-1487.
5. O'Byrne PM: Global guidelines for asthma management: Summary of the current status and future challenges. Pol Arch Med Wewn 2010; 120: 511-517.
6. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of tyrosinespecific protein kinases. J Biol Chem 1987; 262: 5592-5595.
7. Levitzki A, Gazit A: Tyrosine kinase inhibition: An approach to drug development. Science 1995; 267: 1782-1788.
8. Yan GR, Xiao CL, He GW, Yin XF, Chen NP, Cao Y, He QY: Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways. Proteomics 2010; 10: 976-986.
9. Sakai T, Kogiso M: Soy isoflavones and immunity. J Med Invest 2008; 55: 167-173.
10. Si H, Liu D: Phytochemical genistein in the regulation of vascular function: New insights. Curr Med Chem 2007; 14: 2581-2589. (Pubitemid 350018471)
11. Branca F: Dietary phyto-oestrogens and bone health. Proc Nutr Soc 2003; 62: 877-887. (Pubitemid 38004985)
12. Helferich WG, Andrade JE, Hoagland MS: Phytoestrogens and breast cancer: A complex story. Inflammopharmacology 2008; 16: 219-226.
13. Butler LM, Koh WP, Lee HP, Yu MC, London SJ: Dietary fiber and reduced cough with phlegm: A cohort study in Singapore. Am J Respir Crit Care Med 2004; 170: 279-287. (Pubitemid 38971413)
14. Butler LM, Koh WP, Lee HP, Tseng M, Yu MC, London SJ: Prospective study of dietary patterns and persistent cough with phlegm among Chinese Singaporeans. Am J Respir Crit Care Med 2006; 173: 264-270. (Pubitemid 43209079)
15. Miyake Y, Sasaki S, Ohya Y, Miyamoto S, Matsunaga I, Yoshida T, Hirota Y, Oda H: Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: The Osaka Maternal and Child Health Study. J Allergy Clin Immunol 2005; 115: 1176-1183. (Pubitemid 40824586)
16. Smith LJ, Holbrook JT, Wise R, Blumenthal M, Dozor AJ, Mastronarde J, Williams L: Dietary intake of soy genistein is associated with lung function in patients with asthma. J Asthma 2004; 41: 833-843. (Pubitemid 40019135)
17. Duan W, Kuo IC, Selvarajan S, Chua KY, Bay BH, Wong WS: Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma. Am J Respir Crit Care Med 2003; 167: 185-192. (Pubitemid 36076078)
18. Regal JF, Fraser DG, Weeks CE, Greenberg NA: Dietary phytoestrogens have anti-inflammatory activity in a guinea pig model of asthma. Proc Soc Exp Biol Med 2000; 223: 372-378. (Pubitemid 30180785)
19. Duan W, Kuo IC, Selvarajan S, Chua KY, Bay BH, Wong WS: Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma. Am J Respir Crit Care Med 2003; 167: 185-192. (Pubitemid 36076078)
20. Rankin JA, Picarella DE, Geba GP, Temann UA, Prasad B, DiCosmo B, Tarallo A, Stripp B, Whitsett J, Flavell RA: Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci USA 1996; 93: 7821-7825. (Pubitemid 26277122)
21. Maddox L, Schwartz DA: The pathophysiology of asthma. Annu Rev Med 2002; 53: 477-498. (Pubitemid 34177892)
22. Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-596. (Pubitemid 27511769)
23. Sel S, Wegmann M, Dicke T, Sel S, Henke W, Yildirim AO, Renz H, Garn H: Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme. J Allergy Clin Immunol 2008; 121: 910-916.
24. Lee CC, Huang HY, Chiang BL: Lentiviralmediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol Ther 2008; 16: 60-65.
25. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-669.
26. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL: Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001; 292: 1907-1910. (Pubitemid 32538365)
27. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002; 295: 336-338. (Pubitemid 34074365)
28. Oh CK, Geba GP, Molfino N: Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 2010; 19: 46-54.
29. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002; 8: 885-889.