Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Tyan, Shiaw Wei ^a   Hsu, Chih Hung ^a   Peng, Kai Lin ^a,b   Chen, Chun Chin ^a   Kuo, Wen Hung ^c   Lee, Eva Y H P ^a,e,f   Shew, Jin Yuh ^a   Chang, King Jen ^c,d   Juan, Li Jung ^a   Lee, Wen Hwa ^a,f  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d CHENG CHING GENERAL HOSPITAL   (Taiwan)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS1 PROTEIN; DNA; HISTONE H3; TRANSCRIPTION FACTOR EZH2; ADAM PROTEIN; ADAMTS1 PROTEIN, HUMAN; PROTEOGLYCAN; SERGLYCIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL INVASION; COCULTURE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FIBROBLAST; HISTONE METHYLATION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC EPIGENESIS; GENETICS; IMMUNOPRECIPITATION; IN VITRO STUDY; METABOLISM; METASTASIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ADAM PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; COCULTURE TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIGENESIS, GENETIC; FEMALE; FIBROBLASTS; HUMANS; IMMUNOPRECIPITATION; NEOPLASM METASTASIS; PROTEOGLYCANS; REAL-TIME POLYMERASE CHAIN REACTION; VESICULAR TRANSPORT PROTEINS;

EID: 84859710342     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035128     Document Type: Article

References (30)

1. Hu M, Polyak K, (2008) Microenvironmental regulation of cancer development. Curr Opin Genet Dev 18: 27-34.
2. Tlsty TD, Coussens LM, (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1: 119-150.
3. Mueller MM, Fusenig NE, (2004) Friends or foes- bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4: 839-849.
4. Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, et al. (2011) Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One 6: e15313.
5. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, et al. (2004) Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6: 17-32.
6. Canals F, Colome N, Ferrer C, Plaza-Calonge Mdel C, Rodriguez-Manzaneque JC, (2006) Identification of substrates of the extracellular protease ADAMTS1 by DIGE proteomic analysis. Proteomics 6 (Suppl 1): S28-35.
7. Kuno K, Okada Y, Kawashima H, Nakamura H, Miyasaka M, et al. (2000) ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Lett 478: 241-245.
8. Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, et al. (2001) Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J Biol Chem 276: 13372-13378.
9. Liu YJ, Xu Y, Yu Q, (2006) Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene 25: 2452-2467.
10. Lu X, Wang Q, Hu G, van Poznak C, Fleisher M, et al. (2009) ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 23: 1882-1894.
11. Rodriguez-Manzaneque JC, Carpizo D, Plaza-Calonge Mdel C, Torres-Collado AX, Thai SN, et al. (2009) Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int J Biochem Cell Biol 41: 800-810.
12. Rocks N, Paulissen G, Quesada-Calvo F, Munaut C, Gonzalez ML, et al. (2008) ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo. Cancer Res 68: 9541-9550.
13. Longpre JM, Leduc R, (2004) Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem 279: 33237-33245.
14. Bird A, (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21.
15. Tremblay KD, Duran KL, Bartolomei MS, (1997) A 5′ 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol Cell Biol 17: 4322-4329.
16. Koken MH, Hoogerbrugge JW, Jasper-Dekker I, de Wit J, Willemsen R, et al. (1996) Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. Dev Biol 173: 119-132.
17. Zhu B, Reinberg D, (2011) Epigenetic inheritance: uncontested? Cell Res 21: 435-441.
18. Wang GG, Allis CD, Chi P, (2007) Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med 13: 363-372.
19. Li B, Carey M, Workman JL, (2007) The role of chromatin during transcription. Cell 128: 707-719.
20. Kouzarides T, (2007) Chromatin modifications and their function. Cell 128: 693-705.
21. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, et al. (2006) ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol 28: 259-272.
22. Yao JY, Zhang L, Zhang X, He ZY, Ma Y, et al. (2010) H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells. J Biol Chem 285: 18828-18837.
23. Sorensen AL, Jacobsen BM, Reiner AH, Andersen IS, Collas P, (2010) Promoter DNA methylation patterns of differentiated cells are largely programmed at the progenitor stage. Mol Biol Cell 21: 2066-2077.
24. Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, et al. (2011) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473: 389-393.
25. Xu Y, Wu F, Tan L, Kong L, Xiong L, et al. (2011) Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell 42: 451-464.
26. Swigut T, Wysocka J, (2007) H3K27 demethylases, at long last. Cell 131: 29-32.
27. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, et al. (2007) UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449: 731-734.
28. Kolset SO, Tveit H, (2008) Serglycin-structure and biology. Cell Mol Life Sci 65: 1073-1085.
29. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, et al. (2005) Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310: 306-310.
30. Hsu CH, Chang MD, Tai KY, Yang YT, Wang PS, et al. (2004) HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. EMBO J 23: 2269-2280.