ARNTL2 and SERPINE1: Potential biomarkers for tumor aggressiveness in colorectal cancer

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 3, 2012, Pages 501-511

  Mazzoccoli, Gianluigi ^a   Pazienza, Valerio ^a   Panza, Anna ^a   Valvano, Maria Rosa ^a   Benegiamo, Giorgia ^a   Vinciguerra, Manlio ^b   Andriulli, Angelo ^a   Piepoli, Ada ^a  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

ARNTL2; Colorectal cancer; SERPINE1

Indexed keywords

MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; ARNTL2 PROTEIN, HUMAN; SERPINE1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR ARNTL; TUMOR MARKER;

ADULT; AGED; ARNTL2 GENE; ARTICLE; CANCER CELL; CANCER GRADING; CANCER INVASION; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN CACO2; CELL STRAIN SW480; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; MARKER GENE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; SERPINE1 GENE; TISSUE SECTION; UPREGULATION; VASCULAR TUMOR; BLOOD; CANCER STAGING; CHEMISTRY; COLORECTAL TUMOR; GENETICS; MIDDLE AGED; MORTALITY; PATHOLOGY; PREDICTIVE VALUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; TUMOR CELL LINE;

ADULT; AGED; AGED, 80 AND OVER; ARNTL TRANSCRIPTION FACTORS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PLASMINOGEN ACTIVATOR INHIBITOR 1; PREDICTIVE VALUE OF TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84859708955     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1126-6     Document Type: Article

References (79)

1. Agostino PV, Harrington ME, Ralph MR, Golombek DA (2009) Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamsters. Chronobiol Int 26:126-133
2. Andreasen PA (2007) PAI-1-a potential therapeutic target in cancer. Curr Drug Targets 8(9):1030-1041 (Pubitemid 47578151)
3. Angleton P, Chandler WL, Schmer G (1989) Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1). Circulation 79:101-106 (Pubitemid 19043680)
4. Bajou K, Masson V, Gerard RD, Schmitt PM, Albert V, Praus M, Lund LR, Frandsen TL, Brunner N, Dano K, Fusenig NE, Weidle U, Carmeliet G, Loskutoff D, Collen D, Carmeliet P, Foidart JM, Noël A (2001) The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J Cell Biol 152(4):777-784 (Pubitemid 34280162)
5. Bertagnolli MM, Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Warren RS, Redston M (2009) Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and Leukemia Group B Protocol 89803. J Clin Oncol 27:1814-1821
6. Beyer BC, Heiss MM, Simon EH, Gruetzner KU, Babic R, Jauch KW, Schildberg FW, Allgayer H (2006) Urokinase system expression in gastric carcinoma: prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens. Cancer 106:1026-1035
7. Boland CR, Thibodeau SN, Hamilton SR (1998) A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257 (Pubitemid 28521189)
8. Cale JM, Li SH, Warnock M, Su EJ, North PR, Sanders KL, Puscau MM, Emal CD, Lawrence DA (2010) Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor- 1. J Biol Chem 285(11):7892-7902
9. Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E, Norat T (2011) Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One 6:e20456
10. Charfi C, Voisin V, Levros LC Jr, Edouard E, Rassart E (2011) Gene profiling of Graffi murine leukemia virus-induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene. Blood 117(6):1899-1910
11. Chu G, Yoshida K, Narahara S, Uchikawa M, Kawamura M, Yamauchi N, Xi Y, Shigeyoshi Y, Hashimoto S, Hattori MA (2011) Alterations of circadian clockworks during differentiation and apoptosis of rat ovarian cells. Chronobiol Int 28:477-487
12. Compton CC (2003) Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 16:376-388 (Pubitemid 36443987)
13. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, Starling N (2010) Colorectal cancer. Lancet 375:1030-1047
14. Czekay RP, Loskutoff DJ (2009) Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism. J Cell Physiol 220(3):655-663
15. Czekay RP, Aertgeerts K, Curriden SA, Loskutoff DJ (2003) Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. J Cell Biol 160(5):781-791 (Pubitemid 36298272)
16. Dardente H, Cermakian N (2007) Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol Int 24:195-213 (Pubitemid 46643411)
17. Darmoul D, Marie J-C, Devaud H, Gratio V, Laburthe M (2001) Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2. Br J Cancer 85:772-779 (Pubitemid 32929479)
18. Dorn J, Harbeck N, Kates R, Magdolen V, Grass L, Soosaipillai A, Schalfeldt B, Diamandis EP, Schmitt M (2006) Disease processes may be reflected by correlations among tissue kallikrein proteases but not proteolytic factors UPA and PAI-1 in primary ovarian carcinoma. Biol Chem 387:1121-1128 (Pubitemid 44200507)
19. Duguay D, Cermakian N (2009) The crosstalk between physiology and circadian clock proteins. Chronobiol Int 26:1479-1513
20. Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, Tamura T (2011) Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. BMC Genomics 12:196
21. Edery I (2000) Circadian rhythms in a nutshell. Physiol Genomics 3:59-74
22. Einholm AP, Pedersen KE, Wind T, Kulig P, Overgaard MT, Jensen JK, Bødker JS, Christensen A, Charlton P, Andreasen PA (2003) Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J 373(Pt 3):723-732 (Pubitemid 36986586)
23. Erren TC, Groß JV, Meyer-Rochow VB (2011) Light, clocks, mood, and cancer: consolidation and novel tests of latitude and instability hypotheses. Chronobiol Int 28:471-473
24. Filipski E, King VM, Li XM, Granda TG, Mormont MC, Liu X (2002) Host circadian clock as a control point in tumor progression. J Natl Cancer Inst 94:690-697 (Pubitemid 34552490)
25. Filipski E, King VM, Etienne MC, Li XM, Claustrat B, Granda TG (2004) Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice. Am J Physiol Regul Integr Comp Physiol 287:R844-R851 (Pubitemid 39280471)
26. Fu L, Lee CC (2003) The circadian clock: pacemaker and tumour suppressor. Nature Rev Cancer 3:350-361 (Pubitemid 37328855)
27. Fu L, Pelicano H, Liu J, Huang P, Lee CC (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111:41-50
28. Ganesh S, Sier CF, Heerding MM, van Krieken JH, Griffioen G, Welvaart K, van de Velde CJ, Verheijen JH, Lamers CB, Verspaget HW (1997) Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes's stage B and C colorectal cancer. Br J Cancer 75:1793-1801 (Pubitemid 27230706)
29. Hastings MH, Reddy AB, Maywood ES (2003) A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4:649-661 (Pubitemid 37280160)
30. Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S (2010) Proxisome proliferator-activated receptor-a mediates high-fat, dietenhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Chronobiol Int 27:1735-1753
31. Huang TS, Grodeland G, Sleire L, Wang MY, Kvalheim G, Laerum OD (2009) Induction of circadian rhythm in cultured human mesenchymal stem cells by serum shock and cAMP analogs in vitro. Chronobiol Int 26:242-257
32. Ikeda M, Yu W, Hirai M, Ebisawa T, Honma S, Yoshimura K, Honma KI, Nomura M (2000) cDNA cloning of a novel bHLHPAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization. Biochem Biophys Res Commun 275:493-502
33. Iurisci I, Filipski E, Sallam H, Harper F, Guettier C, Maire I, Hassan M, Iacobelli S, Lévi F (2009) Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib. Chronobiol Int 26:1169-1188
34. Iwamoto J, Mizokami Y, Takahashi K, Nakajima K, Ohtsubo T, Miura S, Narasaka T, Takeyama H, Omata T, Shimokobe K, Ito M, Takehara H, Matsuoka T (2005) Expressions of urokinasetype plasminogen activator, its receptor and plasminogen activator inhibitor-1 in gastric cancer and effects of Helicobacter pylori. Scand J Gastroenterol 40:783-793 (Pubitemid 40978853)
35. Jensen SA, Vainer B, Kruhøffer M, Sørensen JB (2009) Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression. BMC Cancer 20:e25
36. Jud C, Chappuis S, Revell VL, Sletten TL, Saaltink DJ, Cajochen C, Skene DJ, Albrecht U (2009) Age-dependent alterations in human PER2 levels after early morning blue light exposure. Chronobiol Int 26:1462-1469
37. Khapre RV, Samsa WE, Kondratov RV (2010) Circadian regulation of cell cycle: molecular connections between aging and the circadian clock. Ann Med 42(6):404-415
38. Kloog I, Haim A, Stevens RG, Portnov BA (2009) Global codistribution of light at night (LAN) and cancers of prostate, colon, and lung in men. Chronobiol Int 26:108-125
39. Koch JM, Hagenauer MH, Lee TM (2009) The response of Per1 to light in the suprachiasmatic nucleus of the diurnal degu (Octodon degus). Chronobiol Int 26:1263-1271
40. Kurnik PB (1995) Circadian variation in the efficacy of tissue-type plasminogen activator. Circulation 91:1341-1346
41. Leibetseder V, Humpeler S, Svoboda M, Schmid D, Thalhammer T, Zuckermann A, Marktl W, Ekmekcioglu C (2009) Clock genes display rhythmic expression in human hearts. Chronobiol Int 26:621-636
42. Leik CE, Su EJ, Nambi P, Crandall DL, Lawrence DA (2006) Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis. J Thromb Haemost 4(12):2710-2715 (Pubitemid 44741569)
43. Lemmer B (2009) Discoveries of rhythms in human biological functions: a historical review. Chronobiol Int 26:1019-1068
44. Lindberg P, Larsson A, Nielsen BS (2006) Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin c-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer 118:2948-2956
45. Liu S, Cai Y, Sothern RB, Guan Y, Chan P (2007) Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice. Chronobiol Int 24:793-820 (Pubitemid 350125645)
46. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCt method. Methods 25:402-408 (Pubitemid 34164012)
47. Lowrey PL, Takahashi JS (2000) Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet 34:533-562 (Pubitemid 32065932)
48. Luo Y, Tian W, Cai L, Wang Y, Zhang J, Teng H, Du J, Sun ZS (2009) Expression profiling reveals a positive regulation by mPer2 on circadian rhythm of cytotoxicity receptors: Ly49C and Nkg2d. Chronobiol Int 26:1514-1544
49. Madsen CD, Sidenius N (2008) The interaction between urokinase receptor and vitronectin in cell adhesion and signalling. Eur J Cell Biol 87(8-9):617-629
50. Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME (2000) CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem 275:36847-36851 (Pubitemid 32002096)
51. Märkl B, Renk I, Oruzio DV, Jähnig H, Schenkirsch G, Schöler C, Ehret W, Arnholdt HM, Anthuber M, Spatz H (2010) Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer. J Surg Oncol 102:235-241
52. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H (2003) Control mechanism of the circadian clock for timing of cell division in vivo. Science 302:255-259 (Pubitemid 37248750)
53. Mazzoccoli G (2011) The timing clockwork of life. J Biol Regul Homeost Agents 25:137-143
54. Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, Schibler U (2004) Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119:693-705 (Pubitemid 39535756)
55. Nielsen HJ, Pappot H, Christensen J, Brünner N, Thorlacius-Ussing O, Moesgaard F, Danø K, Grøndahl-Hansen J (1998) Association between plasma concentrations of plasminogen activator inhibitor-1 and survival in patients with colorectal cancer. BMJ 316:829-830 (Pubitemid 28112429)
56. Offersen BV, Pfeiffer P, Andreasen P, Overgaard J (2007) Urokinase plasminogen activator and plasminogen activator inhibitor type- 1 in normal-cell lung cancer: relation to prognosis and angiogenesis. Lung Cancer 43:43-50 (Pubitemid 46356642)
57. Oishi K (2009) Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders. Clin Exp Hypertens 31:208-219
58. Oishi K, Miyazaki K, Uchida D, Ohkura N, Wakabayashi M, Doi R, Matsuda J, Ishida N (2009) PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice. J Mol Cell Cardiol 46:545-552
59. Polidarová L, Soták M, Sládek M, Pacha J, Sumová A (2009) Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Chronobiol Int 26:607-620
60. Rodrigues RF, Roque L, Krug T, Leite V (2007) Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines. Br J Cancer 96(8):1237-1245 (Pubitemid 46625062)
61. Sakakibara T, Hibi K, Koike M, Fujiwara M, Kodera Y, Ito K, Nakao A (2005) Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer. Br J Cancer 93:799-803 (Pubitemid 41486440)
62. Sakakibara T, Hibi K, Koike M, Fujiwara M, Kodera Y, Ito K, Nakao A (2006) Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer. Cancer Sci 97:395-399
63. Samarakoon R, Higgins CE, Higgins SP, Higgins PJ (2009) TGFbeta1- induced expression of the poor prognosis SERPINE1/PAI- 1 gene requires EGFR signaling: a new target for anti-EGFR therapy. J Oncol 2009:342391
64. Sasaki M, Yoshitane H, Du NH, Okano T, Fukada Y (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem 284:25149-25159
65. Schibler U, Sassone-Corsi P (2002) A web of circadian pacemakers. Cell 111:919-922 (Pubitemid 36044683)
66. Schoenhard JA, Eren M, Johnson CH, Vaughan DE (2002) Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. Am J Physiol Cell Physiol 283:C103-C114 (Pubitemid 34670553)
67. Schoenhard JA, Smith LH, Painter CA, Eren M, Johnson CH, Vaughan DE (2003) Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J Mol Cell Cardiol 35:473-481 (Pubitemid 36539453)
68. Schwimmer H, Mursu N, Haim A (2010) Effects of light and melatonin treatment on body temperature and melatonin secretion daily rhythms in a diurnal rodent, the fat sand rat. Chronobiol Int 27:1401-1419
69. Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH (2010) Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Curr Biol 20:316-321
70. Sier CF, Vloedgraven HJM, Ganesh S, Griffioen G, Quax PH, Verheijen JH, Dooijewaard G, Welvaart K, van de Velde CJ, Lamers CB (1994) Inactive urokinase and increased levels of its inhibitors type 1 in colorectal cancer liver metastasis. Gastroenterology 107:1449-1456 (Pubitemid 24328284)
71. Speleman L, Kerrebijn JD, Look MP, Meeuwis CA, Fockens JA, Berns EM (2007) Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma. Head Neck 29:341-350 (Pubitemid 46623499)
72. Takahashi JS, Hong HK, Ko CH, McDearmon EL (2008) The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 9:764-775
73. Talieri M, Papadopoulou S, Scorilas A, Xynopoulos D, Arnogianaki N, Plataniotis G, Yotis J, Agnanti N (2004) Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma. Cancer Lett 205:97-106 (Pubitemid 38230144)
74. Troy AM, Sheahan K, Mulcahy HE, Duffy MJ, Hyland JM, O'Donoughe DP (2004) Expression of cathepsin B and L antigen and activity is associated with early colorectal progression. Eur J Cancer 40:1610-1616 (Pubitemid 38757752)
75. Vial D, McKeown-Longo PJ (2008) PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. J Cell Sci 121(Pt 10):1661-1670 (Pubitemid 351911823)
76. Wille JJ Jr (2003) Circadian rhythm of tumor promotion in the twostage model of mouse tumorigenesis. Cancer Lett 190:143-149 (Pubitemid 36136012)
77. Wright CM, Dent OF, Newland RC, Barker M, Chapuis PH, Bokey EL, Young JP, Leggett BA, Jass JR, Macdonald GA (2005) Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma. Gut 54:103-108 (Pubitemid 40007227)
78. Yamamura Y, Yano I, Kudo T, Shibata S (2010) Time-dependent inhibitory effect of lipopolysaccharide injection on Per1 and Per2 gene expression in the mouse heart and liver. Chronobiol Int 27:213-232
79. Yeh CT, Lu SC, Tseng IC, Lai HY, Tsao ML, Huang SF, Liaw YF (2003) Antisense overexpression of BMAL2 enhances cell proliferation. Oncogene 22:5306-5314