메뉴 건너뛰기




Volumn 166, Issue 1, 2012, Pages 1-3

Secretin family (Class B) G protein-coupled receptors - From molecular to clinical perspectives

Author keywords

CGRP; family B; G protein coupled receptor; GPCR; secretin

Indexed keywords

AMYLIN RECEPTOR; CALCITONIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; SECRETIN;

EID: 84859705032     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01810.x     Document Type: Review
Times cited : (16)

References (31)
  • 1
    • 80053374553 scopus 로고    scopus 로고
    • Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development
    • Archbold JK, Flanagan JU, Watkins HA, Gingell JJ, Hay DL, (2011). Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development. Trends Pharmacol Sci 32: 591-600.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 591-600
    • Archbold, J.K.1    Flanagan, J.U.2    Watkins, H.A.3    Gingell, J.J.4    Hay, D.L.5
  • 2
    • 84859023464 scopus 로고    scopus 로고
    • Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts
    • Axelsen L, Keung W, Pedersen H, Meier E, Riber D, Kjolbye A, et al,. (2012). Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts. Br J Pharmacol 165: 2736-2748.
    • (2012) Br J Pharmacol , vol.165 , pp. 2736-2748
    • Axelsen, L.1    Keung, W.2    Pedersen, H.3    Meier, E.4    Riber, D.5    Kjolbye, A.6
  • 3
    • 84859727546 scopus 로고    scopus 로고
    • Pharmacological characterization of rat amylin receptors: Implications for the identification of amylin receptor subtypes
    • Bailey RJ, Walker CS, Ferner AH, Loomes KM, Prijic G, Halim A, et al,. (2012). Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes. Br J Pharmacol 166: 151-167.
    • (2012) Br J Pharmacol , vol.166 , pp. 151-167
    • Bailey, R.J.1    Walker, C.S.2    Ferner, A.H.3    Loomes, K.M.4    Prijic, G.5    Halim, A.6
  • 5
    • 84859703456 scopus 로고    scopus 로고
    • VPAC receptors: Structure, molecular pharmacology and interaction with accessory proteins
    • Couvineau A, Laburthe M, (2012). VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins. Br J Pharmacol 166: 42-50.
    • (2012) Br J Pharmacol , vol.166 , pp. 42-50
    • Couvineau, A.1    Laburthe, M.2
  • 6
    • 84857772149 scopus 로고    scopus 로고
    • The structure and function of the glucagon-like peptide-1 receptor and its ligands
    • Donnelly D, (2012). The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br J Pharmacol 166: 27-41.
    • (2012) Br J Pharmacol , vol.166 , pp. 27-41
    • Donnelly, D.1
  • 7
    • 65549137630 scopus 로고    scopus 로고
    • G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases
    • Dunworth WP, Caron KM, (2009). G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases. Arterioscler Thromb Vasc Biol 29: 650-656.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 650-656
    • Dunworth, W.P.1    Caron, K.M.2
  • 8
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB, (2003). The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63: 1256-1272.
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 9
    • 84859716892 scopus 로고    scopus 로고
    • Consequences of splice variation on Secretin family G protein-coupled receptor function
    • Furness SGB, Wootten D, Christopoulos A, Sexton PM, (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. Br J Pharmacol 166: 98-109.
    • (2012) Br J Pharmacol , vol.166 , pp. 98-109
    • Furness, S.G.B.1    Wootten, D.2    Christopoulos, A.3    Sexton, P.M.4
  • 10
    • 79961236811 scopus 로고    scopus 로고
    • 'Biasing' the parathyroid hormone receptor: A novel anabolic approach to increasing bone mass?
    • Gesty-Palmer D, Luttrell LM, (2011). 'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? Br J Pharmacol 164: 59-67.
    • (2011) Br J Pharmacol , vol.164 , pp. 59-67
    • Gesty-Palmer, D.1    Luttrell, L.M.2
  • 11
    • 82255172411 scopus 로고    scopus 로고
    • Structure-based discovery of allosteric modulators of two related class B G-protein-coupled receptors
    • de Graaf C, Rein C, Piwnica D, Giordanetto F, Rognan D, (2011). Structure-based discovery of allosteric modulators of two related class B G-protein-coupled receptors. ChemMedChem 6: 2159-2169.
    • (2011) ChemMedChem , vol.6 , pp. 2159-2169
    • De Graaf, C.1    Rein, C.2    Piwnica, D.3    Giordanetto, F.4    Rognan, D.5
  • 12
    • 4444351153 scopus 로고    scopus 로고
    • NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor
    • Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, et al,. (2004). NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc Natl Acad Sci U S A 101: 12836-12841.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12836-12841
    • Grace, C.R.1    Perrin, M.H.2    Digruccio, M.R.3    Miller, C.L.4    Rivier, J.E.5    Vale, W.W.6
  • 13
    • 78649649695 scopus 로고    scopus 로고
    • NMR structure of the first extracellular domain of corticotropin- releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist
    • Grace CR, Perrin MH, Gulyas J, Rivier JE, Vale WW, Riek R, (2010). NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist. J Biol Chem 285: 38580-38589.
    • (2010) J Biol Chem , vol.285 , pp. 38580-38589
    • Grace, C.R.1    Perrin, M.H.2    Gulyas, J.3    Rivier, J.E.4    Vale, W.W.5    Riek, R.6
  • 14
    • 84859713916 scopus 로고    scopus 로고
    • Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction
    • Grammatopoulos DK, (2012). Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction. Br J Pharmacol 166: 85-97.
    • (2012) Br J Pharmacol , vol.166 , pp. 85-97
    • Grammatopoulos, D.K.1
  • 15
    • 77956336134 scopus 로고    scopus 로고
    • Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism
    • ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, et al,. (2010). Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure 18: 1083-1093.
    • (2010) Structure , vol.18 , pp. 1083-1093
    • Ter Haar, E.1    Koth, C.M.2    Abdul-Manan, N.3    Swenson, L.4    Coll, J.T.5    Lippke, J.A.6
  • 16
    • 84859698659 scopus 로고    scopus 로고
    • Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1
    • Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, et al,. (2012). Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1. Br J Pharmacol 166: 4-17.
    • (2012) Br J Pharmacol , vol.166 , pp. 4-17
    • Harmar, A.J.1    Fahrenkrug, J.2    Gozes, I.3    Laburthe, M.4    May, V.5    Pisegna, J.R.6
  • 18
    • 84856528059 scopus 로고    scopus 로고
    • The pharmacology of Adrenomedullin 2/Intermedin
    • Hong Y, Hay DL, Quirion R, Poyner DR, (2012). The pharmacology of Adrenomedullin 2/Intermedin. Br J Pharmacol 166: 110-120.
    • (2012) Br J Pharmacol , vol.166 , pp. 110-120
    • Hong, Y.1    Hay, D.L.2    Quirion, R.3    Poyner, D.R.4
  • 19
    • 79959848145 scopus 로고    scopus 로고
    • Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice
    • Kadmiel M, Fritz-Six K, Pacharne S, Richards GO, Li M, Skerry TM, et al,. (2011). Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice. Mol Endocrinol 25: 1244-1253.
    • (2011) Mol Endocrinol , vol.25 , pp. 1244-1253
    • Kadmiel, M.1    Fritz-Six, K.2    Pacharne, S.3    Richards, G.O.4    Li, M.5    Skerry, T.M.6
  • 20
    • 77957280365 scopus 로고    scopus 로고
    • Identification of a novel corticotropin-releasing hormone type 1beta-like receptor variant lacking Exon 13 in human pregnant myometrium regulated by estradiol-17beta and progesterone
    • Karteris E, Markovic D, Chen J, Hillhouse EW, Grammatopoulos DK, (2010). Identification of a novel corticotropin-releasing hormone type 1beta-like receptor variant lacking Exon 13 in human pregnant myometrium regulated by estradiol-17beta and progesterone. Endocrinology 151: 4959-4968.
    • (2010) Endocrinology , vol.151 , pp. 4959-4968
    • Karteris, E.1    Markovic, D.2    Chen, J.3    Hillhouse, E.W.4    Grammatopoulos, D.K.5
  • 21
    • 84855799592 scopus 로고    scopus 로고
    • Diversity and modularity of G protein-coupled receptor structures
    • Katritch V, Cherezov V, Stevens RC, (2011). Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci 33: 17-27.
    • (2011) Trends Pharmacol Sci , vol.33 , pp. 17-27
    • Katritch, V.1    Cherezov, V.2    Stevens, R.C.3
  • 22
    • 84856185720 scopus 로고    scopus 로고
    • Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding
    • doi: 10.1002/pro.2003
    • Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda KI, Sakamoto K, et al,. (2011). Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. Protein Sci. doi: 10.1002/pro.2003.
    • (2011) Protein Sci
    • Kusano, S.1    Kukimoto-Niino, M.2    Hino, N.3    Ohsawa, N.4    Okuda, K.I.5    Sakamoto, K.6
  • 23
    • 84859723390 scopus 로고    scopus 로고
    • The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling
    • Kuwasako K, Hay DL, Nagata K, Hikosaka T, Kitamura K, Kato J, (2012). The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling. Br J Pharmacol 166: 137-150.
    • (2012) Br J Pharmacol , vol.166 , pp. 137-150
    • Kuwasako, K.1    Hay, D.L.2    Nagata, K.3    Hikosaka, T.4    Kitamura, K.5    Kato, J.6
  • 25
    • 84859724051 scopus 로고    scopus 로고
    • Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor
    • Miller LJ, Dong M, Harikumar KG, (2012). Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor. Br J Pharmacol 166: 18-26.
    • (2012) Br J Pharmacol , vol.166 , pp. 18-26
    • Miller, L.J.1    Dong, M.2    Harikumar, K.G.3
  • 26
    • 84859726761 scopus 로고    scopus 로고
    • Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine
    • Moore EL, Salvatore CA, (2012). Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine. Br J Pharmacol 166: 66-78.
    • (2012) Br J Pharmacol , vol.166 , pp. 66-78
    • Moore, E.L.1    Salvatore, C.A.2
  • 27
    • 78650036810 scopus 로고    scopus 로고
    • Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor
    • Pal K, Swaminathan K, Xu HE, Pioszak AA, (2010). Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. J Biol Chem 285: 40351-40361.
    • (2010) J Biol Chem , vol.285 , pp. 40351-40361
    • Pal, K.1    Swaminathan, K.2    Xu, H.E.3    Pioszak, A.A.4
  • 29
    • 42449160533 scopus 로고    scopus 로고
    • Molecular recognition of parathyroid hormone by its G protein-coupled receptor
    • Pioszak AA, Xu HE, (2008). Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci U S A 105: 5034-5039.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5034-5039
    • Pioszak, A.A.1    Xu, H.E.2
  • 30
    • 84859733684 scopus 로고    scopus 로고
    • GLP-1R and amylin agonism in metabolic disease: Complementary mechanisms and future opportunities
    • Roth JD, Erickson MR, Chen S, Parkes DG, (2012). GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities. Br J Pharmacol 166: 121-136.
    • (2012) Br J Pharmacol , vol.166 , pp. 121-136
    • Roth, J.D.1    Erickson, M.R.2    Chen, S.3    Parkes, D.G.4
  • 31
    • 45549086826 scopus 로고    scopus 로고
    • Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
    • Runge S, Thogersen H, Madsen K, Lau J, Rudolph R, (2008). Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 283: 11340-11347.
    • (2008) J Biol Chem , vol.283 , pp. 11340-11347
    • Runge, S.1    Thogersen, H.2    Madsen, K.3    Lau, J.4    Rudolph, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.