Structural basis for hormone recognition by the human CRFR2α G protein-coupled receptor

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40351-40361

  Pal, Kuntal ^a,b   Swaminathan, Kunchithapadam ^b   Xu, H Eric ^a   Pioszak, Augen A ^a,c  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR FUNCTION; CLASS B; COMPATIBILITY MECHANISMS; CORTICOTROPIN-RELEASING FACTORS; ELECTROSTATIC SURFACES; EXTRACELLULAR DOMAINS; G PROTEIN COUPLED RECEPTORS; ISOFORMS; LIGAND RECOGNITION; MOLECULAR BASIS; MOLECULAR TEMPLATE; N-TERMINALS; NON-POLAR; PEPTIDE HORMONES; PEPTIDE-BINDING; PSEUDO-SIGNAL; RATIONAL DESIGN; SELECTIVITY FILTER; STRESS RESPONSE; STRUCTURAL BASIS; THERAPEUTIC AGENTS;

AMINO ACIDS; ELECTROCHROMIC DEVICES; GENE ENCODING; HORMONES; LIGANDS; MAMMALS; REDUCTION;

PEPTIDES;

ALANINE; AMINO ACID; ARGININE; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2ALPHA; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; ISOPROTEIN; LIGAND; PEPTIDE; PROLINE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; UROCORTIN I; UROCORTIN II; UROCORTIN III;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; HORMONE BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; STATIC ELECTRICITY; SURFACE CHARGE;

ANIMALS; BINDING SITES; CORTICOTROPIN-RELEASING HORMONE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; UROCORTINS;

MAMMALIA;

EID: 78650036810     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.186072     Document Type: Article

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