Leptin relieves intestinal ischemia/reperfusion injury by promoting ERK1/2 phosphorylation and the NO signaling pathway

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 1, 2012, Pages 143-149

  Deng Jr , Zi Hui ^a   Yan, Guang Tao ^a   Wang, Lu Huan ^a   Zhang, Jin Ying ^a   Xue, Hui ^a   Zhang, Kai ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Intestinal I R injury; Leptin; Mucosal repair; Nitric oxide; Oxygen radicals

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; INTERLEUKIN 6; LEPTIN; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHOSPHOLIPASE A2; ANTIOXIDANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CELL HYPOXIA; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; INTESTINE ISCHEMIA; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ARTICLE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; INTESTINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-6; INTESTINES; LEPTIN; MALE; MALONDIALDEHYDE; MAP KINASE SIGNALING SYSTEM; MICE; NITRIC OXIDE; PHOSPHOLIPASES A2; PHOSPHORYLATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84859648465     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182222f67     Document Type: Conference Paper

References (21)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
2. Baratta M. Leptin-from a signal of adiposity to a hormonal mediator in peripherial tissues. Med Sci Monit. 2002;8:282-292.
3. Lin J, Yan GT, Wang LH, Hao XH, Zhang K, Xue H. Leptin fluctuates in intestinal ischemia-reperfusion injury as inflammatory cytokine. Peptides. 2004;25:2187-2193.
4. Lin J, Yan G. Roles of leptin-mediated intracellular signaling pathways on wound healing. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007;21:1254-1258.
5. Sukhotnik I, Coran AG, Mogilner JG, et al. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Pediatr Res. 2009;66:648-653.
6. Sáinz N, Rodríguez A, Catalán V, et al. Leptin administration downregulates the increased expression levels of gene related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice. Mediators Inflamm. 2010;2010:784343.
7. Yan GT, Lin J, Hao XH, Xue H, Zhang K, Wang LH. Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. Eur J Pharmacol. 2009;616:244-250.
8. Fernández-Riejos P, Goberna R, Sánchez-Margalet V. Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase. Clin Exp Immunol. 2008;151:505-518.
9. Mahapatra SK, Das S, Bhattacharjee S, Gautam N, Majumdar S, Roy S. In vitro nicotine-induced oxidative stress in mice peritoneal macrophages: a dose-dependent approach. Toxicol Mech Methods. 2009;19: 100-108.
10. Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006;281:29776-29787.
11. Chiu CJ, Mc Ardle AH, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101:478-483.
12. Slomiany BL, Slomiany A. Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways in leptin protection of gastric mucosa against ethanol cytotoxicity. J Physiol Pharmacol. 2008;59:301-314.
13. Oldenburg MD, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med. 2004;164: 1054-1062.
14. Hacioglu A, Algin C, Pasaoglu O, Pasaoglu E, Kanbak G. Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine. BMC Gastroenterol. 2005;21:37.
15. Breithaupt-Faloppa AC, Vitoretti LB, Coelho FR, et al. Nitric oxide mediates lung vascular permeability and lymph-borne IL-6 after an intestinal ischemic insult. Shock. 2009;32:55-61.
16. Lanas A. Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther. 2008;10 suppl 2:S4.
17. Das A, Salloum FN, Xi L, Rao YJ, Kukreja RC. ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol. 2009;296: H1236-H1243.
18. Zhang F, Chen J. Leptin protects hippocampal CA1 neurons against ischemic injury. J Neurochem. 2008;107:578-587.
19. Slomiany BL, Slomiany A. Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. J Physiol Pharmacol. 2005;56:531-541.
20. Kuwata H, Nakatani Y, Murakami M, Kudo I. Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. J Biol Chem. 1998;273:1733-1740.
21. Slomiany BL, Slomiany A. Leptin-induced cytosolic phospholipase A2 activation in gastric mucosal protection against ethanol cytotoxicity involves epidermal growth factor receptor transactivation. Inflammopharmacology. 2009;17:6-14.