Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways in leptin protection of gastric mucosa against ethanol cytotoxicity

Journal of Physiology and Pharmacology

Volumn 59, Issue 2, 2008, Pages 301-314

  Slomiany, B L ^a,b   Slomiany, A ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

cNOS; cPLA2; Ethanol cytotoxicity; Gastric mucosal protection; Leptin; PGE2; Src activation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ALCOHOL; CONSTITUTIVE NITRIC OXIDE SYNTHASE; INDOMETACIN; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE A2; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; WORTMANNIN;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME MECHANISM; INHIBITION KINETICS; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; RAT; STOMACH MUCOSA;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ETHANOL; GASTRIC MUCOSA; LEPTIN; MICE; NITRIC OXIDE SYNTHASE; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 46849119207     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Fruhbeck G. Intracellular signaling pathways activated by leptin. Biochem J 2006; 393: 7-20.
2. Bado A, Lavasseur S, Attoub S, et al. The stomach is a source of leptin. Nature 1998; 394: 790-793.
3. Konturek PC, Brzozowski T, Sulekova Z, et al. Role of leptin in ulcer healing. Eur J Pharmacol 2001; 414: 87-97.
4. Sobhani I., Bado A., Visuzaine C. et al. Leptin secretion and leptin receptor in the human stomach. Gut 200; 47: 178-183.
5. Takahashi N, Waelput W, Guisez Y. (1999). Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 1999; 189: 207-212.
6. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune responses and immunodeficiency of malnutrition. FASEB J. 2001; 15: 2565-2571.
7. Konturek PC, Brzozowski T, Sulekova Z, et al. Enhanced expression of leptin following acute gastric injury in rat. J Physiol Pharmacol 1999; 50: 587-595.
8. Brzozowski T, Konturek PC, Konturek SJ, et al. Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. Eur J Pharmacol 1999; 374: 263-276.
9. Guslandi M. Effects of ethanol on the gastric mucosa. Dig Dis Sci 1987; 5: 21-32.
10. Konturek SJ, Brzozowski T, Konturek W, et al. Growth factors in gastric mucosal integrity, protection and healing of acute and chronic ulcerations. In The Stomach, W Domschke, SJ Konturek (eds). Berlin, Springer-Verlag, 1993, pp. 159-176.
11. Mastronardi CA, Yu WH, McCann SM. Resting and circadian release of nitric oxide is controlled by leptin in male rats. Proc Natl Acad Sci USA 2002; 99: 5721-5726.
12. Vecchione C, Maffei A, Collela S, et al. Leptin effect on endothelial nitric oxide synthase is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002; 51: 168-173.
13. Kim GS, Hong JS, Kim SW, et al. Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. J Biol Chem 2003; 278: 21920-21929.
14. 2 activation in gastric mucosal cells. J Physiol Pharmacol 2007; 58: 117-130.
15. Yamada M, Watanabe M, Mue S, et al. Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2. J Pharmacol Exp Ther 1996; 277: 1607-1614.
16. 2 as defined by gene knockout. Biochim Biophys Acta 2000; 1488:139-148.
17. 2+- dependent death. J Biol Chem 2006; 281: 6106-6116.
18. 2. Biochim Biophys Acta 2000; 1488: 124-138.
19. 1 macrophages using GFP/REP constructs. Biochim Biophys Acta 2005; 1735: 119-129.
20. 2 activation on salivary mucin synthesis via ERK-signal transduction. Inflammopharmacol 2006; 14: 250-255.
21. 2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. IUBMB Life 2006; 58: 217-223.
22. 2 activation by Porphyromonas gingivalis: role of leptin. J Appl Res 2007; 7: 127-136.
23. 15N]nitrate in biological fluids. Anal Biochem 1982; 126: 131-138.
24. Slomiany BL, Slomiany A. Role of epidermal growth factor receptor transactivation in PPARγ-dependent suppression of Helicobacter pylori interference with gastric mucin synthesis. Inflammopharmacol 2004; 12: 177-188.
25. Anter E, Thomas SR, Schulz E, et al. ( Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem 2004; 279: 46637-46643.
26. 2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem 2005; 280: 38969-38975.
27. Haynes MP, Li L, Sinha D, et al. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem 2003; 278: 2118-2123.
28. Lorenz M, Wessler S, Follmann E, et al. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phopsphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 2004; 279: 6190-6195.
29. Takagi A, Slomiany BL, Kosmala M, et al. Changes in mucus glycoprotein synthesized in rat gastric mucosa exposed to ethanol. Biochim Biophys Acta 1986; 884: 1-10.
30. Wu-Wang CY, Wang SL, Lim C, et al. Impairment by ethanol of prostaglandin production in rat salivary glands. Archs Oral Biol 1999; 36: 9-13.
31. Slomiany BL, Slomiany A. Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair. J Physiol Pharmacol 2005; 56: 531-541.