Preparation of two novel monobrominated 2-(2',4'-dihydroxybenzoyl)-3,4,5,6-tetrachlorobenzoic acids and their separation from crude synthetic mixtures using vortex counter-current chromatography

Journal of Chromatography A

Volumn 1237, Issue , 2012, Pages 106-114

  Weisz, Adrian ^a   Witten, Jacob J ^b,c   Zeng, Yun ^b,d   Mazzola, Eugene P ^a   Ito, Yoichiro ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c AMHERST COLLEGE   (United States)

^d AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

Author keywords

2 (2',4' Dihydroxy 3' bromobenzoyl) 3,4,5,6 tetrachlorobenzoic acid; 2 (2',4' Dihydroxy 5' bromobenzoyl) 3,4,5,6 tetrachlorobenzoic acid; Chemoselective ortho bromination; PH zone refining CCC; VCCC; Vortex counter current chromatography

Indexed keywords

AQUEOUS AMMONIA; CHEMOSELECTIVE; COLOR ADDITIVES; COLOR INDEX; COUNTERCURRENT CHROMATOGRAPHY; FOOD AND DRUG ADMINISTRATION; GLACIAL ACETIC ACID; HIGH RESOLUTION MASS SPECTROMETRY; ISOLATED COMPOUNDS; MONOBROMINATION; PH-ZONE-REFINING CCC; POSITIONAL ISOMERS; PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLVENT SYSTEM; SYNTHETIC MIXTURES; TRIFLUOROACETIC ACIDS; TWO-PHASE SOLVENT SYSTEM; VCCC; VOLUME RATIO;

ACETIC ACID; HEXANE; MASS SPECTROMETRY; METHANOL; MIXTURES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC SOLVENTS; REFINING; SEPARATION; VORTEX FLOW;

CHROMATOGRAPHY;

2 (2',4' DIHYDROXYBENZOYL) 3,4,5,6 TETRACHLOROBENZOIC ACID; ACETIC ACID; ACETIC ACID ETHYL ESTER; AMMONIA; BROMINE; CHLOROBENZOIC ACID DERIVATIVE; HEXANE; METHANOL; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER;

ARTICLE; BROMINATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PHASE SEPARATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VORTEX COUNTER CURRENT CHROMATOGRAPHY;

BENZOIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUNTERCURRENT DISTRIBUTION; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84859645353     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.040     Document Type: Article

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