Isolation of 4′-bromo-4,5,6,7-tetrachlorofluorescein from a synthetic mixture by pH-zone-refining counter-current chromatography with continuous pH monitoring

Journal of Chromatography A

Volumn 732, Issue 2, 1996, Pages 283-290

  Weisz, Adrian ^a   Scher, Alan L ^a   Ito, Yoichiro ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Bromotetrachlorofluorescein; Color additives; Counter current chromatography; Preparative chromatography

Indexed keywords

4' BROMO 4,5,6,7 TETRACHLOROFLUORESCEIN; FLUORESCEIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; COUNTER CURRENT CHROMATOGRAPHY; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONITORING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROPHOTOMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; FLUORESCEINS; FOOD ADDITIVES; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0029922374     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9673(95)01266-4     Document Type: Article

References (7)

1. A. Weisz, A.L. Scher, K. Shinomiya, H.M. Fales and Y. Ito, J. Am. Chem. Soc., 116 (1994) 704-708.
2. Y. Ito and A. Weisz, pH-Zone-Refining Countercurrent Chromatography, US Patent 5 332 504, July 26, 1994.
3. Y. Ito, K. Shinomiya, H.M. Fales, A. Weisz and A.L. Scher, in W.D. Conway and R.J. Petroski (Editors), Modern Countercurrent Chromatography, ACS Symp. Ser. Vol. 593, American Chemical Society, Washington, DC, 1995, Ch. 14, pp. 156-183.
4. A. Weisz, A.L. Scher, D. Andrzejewski and Y. Ito, presented at the 10th International Symposium on Preparative Chromatography, Arlington, VA, June 14-16, 1993, abstract 320.
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7. A. Weisz, A.L. Scher, D. Andrzejewski, Y. Shibusawa and Y. Ito, J. Chromatogr., 607 (1992) 47-53.