Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway

Acta Pharmacologica Sinica

Volumn 33, Issue 4, 2012, Pages 551-557

  Zhang, Yan Jun ^a,b   Lu, Cheng Rong ^a   Cao, Yan ^a,b   Luo, Yuan ^a   Bao, Rong Feng ^a   Yan, Shu ^a,c   Xue, Mei ^a   Zhu, Feng ^d   Wang, Zhe ^a   Duan, Lian Ning ^a  

^a AIR FORCE GENERAL HOSPITAL   (China)

^b HEBEI NORTH UNIVERSITY   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

acetylation; apoptosis; caspase 3; chronic myelogenous leukemia; H2AX; imatinib; mammalian STE20 like kinase 1 (Mst1); phosphorylation; Williams Beuren syndrome transcription factor; Z VAD

Indexed keywords

BCR ABL PROTEIN; CASPASE 3; HISTONE H2AX; IMATINIB; LYSINE; MAMMALIAN STE20 LIKE KINASE 1; P53 INDUCED PHOSPHATASE 1; PHOSPHATASE; PHOSPHOTRANSFERASE; SERINE; TRANSCRIPTION FACTOR; TYROSINE; UNCLASSIFIED DRUG; WILLIAMS BEUREN SYNDROME TRANSCRIPTION FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CARBOXY TERMINAL SEQUENCE; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LEUKEMIA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; HEPATOCYTE GROWTH FACTOR; HISTONES; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PHOSPHORYLATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PYRIMIDINES; SIGNAL TRANSDUCTION;

EID: 84859608162     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.9     Document Type: Article

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