Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma

Biochemical and Biophysical Research Communications

Volumn 420, Issue 3, 2012, Pages 680-684

  Zheng, Long Yi ^a   Zhou, Dong Xun ^b   Lu, Jin ^a   Zhang, Wen Jun ^a   Zou, Da Jin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b EASTERN HEPATOBILIARY SURGERY HOSPITAL   (China)

Author keywords

Catenin; Hepatocellular carcinoma; Prognosis; PTP1B; Tumor initiating cells

Indexed keywords

BETA CATENIN; PROTEIN TYROSINE PHOSPHATASE 1B; WNT PROTEIN;

ADULT; ARTICLE; CANCER SURVIVAL; CLINICAL FEATURE; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADULT; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL NUCLEUS; DOWN-REGULATION; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84859586860     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.066     Document Type: Article

References (27)

1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics 2010. CA Cancer J. Clin. 2010, 60:277-300.
2. Tung-Ping Poon R., Fan S.T., Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann. Surg. 2000, 232:10-24.
3. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
4. Yip S.C., Saha S., Chernoff J. PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem. Sci. 2010, 35:442-449.
5. Lessard L., Stuible M., Tremblay M.L. The two faces of PTP1B in cancer. Biochim. Biophys. Acta 1804, 2010:613-619.
6. Delibegovic M., Zimmer D., Kauffman C., Rak K., Hong E.G., Cho Y.R., Kim J.K., Kahn B.B., Neel B.G., Bence K.K. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 2009, 58:590-599.
7. Gonzalez-Rodriguez A., Escribano O., Alba J., Rondinone C.M., Benito M., Valverde A.M. Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J. Cell. Physiol. 2007, 212:76-88.
8. Visvader J.E. Cells of origin in cancer. Nature 2011, 469:314-322.
9. Yang W., Yan H.X., Chen L., Liu Q., He Y.Q., Yu L.X., Zhang S.H., Huang D.D., Tang L., Kong X.N., Chen C., Liu S.Q., Wu M.C., Wang H.Y. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008, 68:4287-4295.
10. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., Normandin D., Cheng A., Himms-Hagen J., Chan C.C., Ramachandran C., Gresser M.J., Tremblay M.L., Kennedy B.P. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
11. Cheng A., Uetani N., Simoncic P.D., Chaubey V.P., Lee-Loy A., McGlade C.J., Kennedy B.P., Tremblay M.L. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev. Cell 2002, 2:497-503.
12. Zabolotny J.M., Bence-Hanulec K.K., Stricker-Krongrad A., Haj F., Wang Y., Minokoshi Y., Kim Y.B., Elmquist J.K., Tartaglia L.A., Kahn B.B., Neel B.G. PTP1B regulates leptin signal transduction in vivo. Dev. Cell 2002, 2:489-495.
13. Haj F.G., Markova B., Klaman L.D., Bohmer F.D., Neel B.G. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J. Biol. Chem. 2003, 278:739-744.
14. Kakazu A., Sharma G., Bazan H.E. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci. 2008, 49:2927-2935.
15. Woodford-Thomas T.A., Rhodes J.D., Dixon J.E. Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. J. Cell Biol. 1992, 117:401-414.
16. Dube N., Cheng A., Tremblay M.L. The role of protein tyrosine phosphatase 1B in Ras signaling. Proc. Natl. Acad. Sci. USA 2004, 101:1834-1839.
17. LaMontagne K.R., Hannon G., Tonks N.K. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. Proc. Natl. Acad. Sci. USA 1998, 95:14094-14099.
18. Julien S.G., Dube N., Read M., Penney J., Paquet M., Han Y., Kennedy B.P., Muller W.J., Tremblay M.L. Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat. Genet. 2007, 39:338-346.
19. Zhu H.H., Ji K., Alderson N., He Z., Li S., Liu W., Zhang D.E., Li L., Feng G.S. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 2011, 117:5350-5361.
20. You-Ten K.E., Muise E.S., Itie A., Michaliszyn E., Wagner J., Jothy S., Lapp W.S., Tremblay M.L. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J. Exp. Med. 1997, 186:683-693.
21. Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 2008, 8:755-768.
22. Fodde R., Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr. Opin. Cell Biol. 2007, 19:150-158.
23. Thompson M.D., Monga S.P. Wnt/beta-catenin signaling in liver health and disease. Hepatology 2007, 45:1298-1305.
24. Hu M., Kurobe M., Jeong Y.J., Fuerer C., Ghole S., Nusse R., Sylvester K.G. Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology 2007, 133:1579-1591.
25. Apte U., Thompson M.D., Cui S., Liu B., Cieply B., Monga S.P. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology 2008, 47:288-295.
26. Nelson W.J., Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004, 303:1483-1487.
27. Xu G., Arregui C., Lilien J., Balsamo J. PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site. J. Biol. Chem. 2002, 277:49989-49997.