Human umbilical cord Wharton's jelly stem cell (hWJSC) extracts inhibit cancer cell growth in vitro

Journal of Cellular Biochemistry

Volumn 113, Issue 6, 2012, Pages 2027-2039

  Gauthaman, Kalamegam ^a   Yee, Fong Chui ^a   Cheyyatraivendran, Suganya ^a   Biswas, Arijit ^a   Choolani, Mahesh ^a   Bongso, Ariff ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

APOPTOSIS; AUTOPHAGY; CANCER CELLS; CELL INHIBITION; HUMAN WHARTON'S JELLY STEM CELL CONDITIONED MEDIUM AND LYSATE

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BECLIN 1; CELL EXTRACT; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; SURVIVIN; UNCLASSIFIED DRUG; WHARTON JELLY STEM CELL EXTRACT;

ARTICLE; AUTOPHAGY; BREAST ADENOCARCINOMA; CANCER GROWTH; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL LYSATE; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NICK END LABELING; OSTEOSARCOMA; OVARY CARCINOMA; PRIORITY JOURNAL; WHARTON JELLY;

EID: 84859582942     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24073     Document Type: Article

References (47)

1. Ayuzawa R, Doi C, Rachakatla RS, Pyle MM, Maurya DK, Troyer D,. 2009. Naîve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo. Cancer Lett 280: 31-37.
2. Bhardwaj A, Singh S, Singh AP,. 2010. MicroRNA-based cancer therapeutics: Big hope from small RNAs. Mol Cell Pharmacol 2: 213-219.
3. Cavarretta IT, Altanerova V, Matuskova M, Kucerova L, Culig Z, Altaner C,. 2010. Adipose tissue-derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth. Mol Ther 18: 223-231.
4. Chamberlain G, Fox J, Ashton B, Middleton J,. 2007. Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25: 2739-2749.
5. Chawla-Sarkar M, Leaman DW, Borden EC,. 2001. Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: Correlation with TRAIL/Apo2L induction in melanoma cell lines. Clin Cancer Res 7: 1821-1831.
6. Collins K, Jacks T, Pavletich NP,. 1997. The cell cycle and cancer. Proc Natl Acad Sci USA 94: 2776-2778.
7. Fong CY, Richards M, Manasi N, Biswas A, Bongso A,. 2007. Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. Reprod Biomed Online 15: 708-718.
8. Fong CY, Chak LL, Subramanian A, Tan JH, Biswas A, Gauthaman K,. 2009. A three dimensional anchorage independent in vitro system for the prolonged growth of embryoid bodies to study cancer cell behaviour and anticancer agents. Stem Cell Rev Rep 5: 410-419.
9. Fong CY, Subramanian A, Biswas A, Gauthaman K, Srikanth P, Hande MP,. 2010a. Derivation efficiency, cell proliferation, frozen-thaw survival, stem cell properties, and differentiation of human Wharton's jelly stem cells. Reprod Biomed Online 21: 391-401.
10. Fong CY, Chak LL, Biswas A, Tan JH, Gauthaman K, Chan WK,. 2010b. Human Wharton's Jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells. Stem Cell Rev Rep 7: 1-16.
11. Fong CY, Subramanian A, Gauthaman K, Venugopal JR, Biswas A, Ramakrishna S,. 2011a. Human Wharton's jelly stem cells undergo enhanced chondrogenic differentiation compared to human bone marrow stem cells when grown on nanoscaffolds and exposed to a sequential two-stage culture medium environment. Stem Cell Rev Rep DOI: 10.1007/s12015-011-9289-8
12. Fong CY, Gauthaman K, Suganya C, Hao DL, Biswas A, Bongso A,. 2011b. Human umbilical cord Wharton's jelly stem cells and its conditioned medium support hematopoietic stem cell expansion ex vivo. J Cell Biochem DOI: 10.1002/jcb.23395
13. Fritz V, Jorgensen C,. 2008. Mesenchymal stem cells: An emerging tool for cancer targeting and therapy. Curr Stem Cell Res Ther 3: 32-42.
14. Ganta C, Chiyo D, Ayuzawa R, Rachakatla R, Pyle M, Andrews G,. 2009. Rat umbilical cord stem cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation. Cancer Res 69: 1815-1820.
15. Gauthaman K, Venugopal JR, Fong CY, Biswas A, Ramakrishna S, Bongso A,. 2010. Osteogenic differentiation of human Wharton's Jelly stem cells on nanofibrous substrates in vitro. Tissue Eng Part A 17: 71-81.
16. Gauthaman K, Fong CY, Suganya CA, Subramanian A, Biswas A, Bongso A,. 2011. Extra-embryonic human Wharton's jelly stem cells do not induce tumorigenesis, unlike human embryonic stem cells. Reprod Biomed DOI: 10.1016/j.rbmo.2011.10.007
17. HÃkelien AM, Collas P,. 2002. Novel approaches to transdifferentiation. Cloning Stem Cells 4: 379-387.
18. Heylen N, Baurain R, Remacle C, Trouet A,. 1998. Effect of MRC-5 fibroblast conditioned medium on breast cancer cell motility and invasion in vitro. Clin Exp Metastasis 16: 193-203.
19. Hosono K, Nishida Y, Knudson W, Knudson CB, Naruse T, Suzuki Y,. 2007. Hyaluronan oligosaccharides inhibit tumorigenicity of osteosarcoma cell lines MG-63 and LM-8 in vitro and in vivo via perturbation of hyaluronan-rich pericellular matrix of the cells. Am J Pathol 171: 274-286.
20. Illancheran S, Michalska A, Peh G, Wallace EM, Pera M, Manuelpillai U,. 2007. Stem cells derived from human fetal membranes display multilineage differentiation potential. Biol Reprod 77: 577-588.
21. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D,. 2011. Global cancer statistics. Cancer J Clin 61: 69-90.
22. Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II,. 2006. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 203: 1235-1247.
23. Kita K, Gauglitz GG, Phan TT, Herndon DN, Jeschke MG,. 2010. Isolation and characterization of mesenchymal stem cells from the subamniotic human umbilical cord lining membrane. Stem Cells Dev 19: 491-502.
24. Kiyono K, Suzuki HI, Matsuyama H, Morishita Y, Komuro A, Kano MR,. 2009. Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res 69: 8844-8852.
25. Klimiuk PA, Goronzy JJ, Weyand CM,. 1999. IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis. J Immunol 162: 4293-4299.
26. Loebinger MR, Sage EK, Davies D, Janes SM,. 2010. TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population. Br J Cancer 103: 1692-1697.
27. Matsuzuka T, Rachakatla RS, Doi C, Maurya DK, Ohta N, Kawabata A,. 2010. Human umbilical cord matrix-derived stem cells expressing interferon-beta gene significantly attenuate bronchioloalveolar carcinoma xenografts in SCID mice. Lung Cancer 70: 28-36.
28. Maurya DK, Doi C, Kawabata A, Pyle MM, King C, Wu Z,. 2010. Therapy with un-engineered naîve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma. BMC Cancer 10 (590): 1-10.
29. Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, Ilancheran S,. 2009. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol 175: 303-313.
30. Mukaida H, Hirabayashi Hirai T, Iwata T, Saeki S, Toge T,. 1991. Significance of freshly cultured fibroblasts from different tissues in promoting cancer cell growth. Int J Cancer 48: 423-427.
31. Nikitovic D, Zafiropoulos A, Tzanakakis GN, Karamanos NK, Tsatsakis AM,. 2005. Effects of glycosaminoglycans on cell proliferation of normal osteoblasts and human osteosarcoma cells depend on their type and fine chemical compositions. Anticancer Res 25: 2851-2856.
32. Olie RA, Simoes-Wust AP, Baumann B, Leech SH, Fabbro D, Stahel RA,. 2000. A novel antisense nucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res 60: 2805-2809.
33. Prockop DJ,. 2009. Repair of tissues by adult stem/progenitor cells (MSCs): Controversies, myths and changing paradigms. Mol Ther 17: 939-946.
34. Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K,. 1999. Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 6: 7797-7802.
35. Rosen LS, Ashurst HL, Chap L,. 2010. Targeting signal transduction pathways in metastatic breast cancer: A comprehensive review. Oncologist 15: 216-235.
36. Sarugaser R, Lickorish D, Baksh D, Hosseini MM, Davies JE,. 2005. Human umbilical cord perivascular (HUCPV) cells: A source of mesenchymal progenitors. Stem Cells 23: 220-229.
37. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH,. 2004. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10: 55-63.
38. Secchiero P, Zorzet S, Tripodo C, Corallini F, Melloni E, Caruso L,. 2010. Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts. PLoS ONE 5: e11140.
39. Seo SH, Kim KS, Park SH, Suh YS, Kim SJ, Jeun SS, Sung YC,. 2011. The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity. Gene Ther 18: 488-495.
40. Subramanian A, Gan SU, Ngo KS, Gauthaman K, Biswas A, Choolani M, Bongso A, Fong CY,. 2012. Human umbilical cord Wharton's jelly mesenchymal stem cells do not transform to tumor-associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells. J Cell Biochem DOI: 10.1002/jcb.24057
41. Sun B, Yu KR, Bhandari DR, Jung JW, Kang SK, Kang KS,. 2010. Human umbilical cord blood mesenchymal stem cell-derived extracellular matrix prohibits metastatic cancer cell MDA-MB-231 proliferation. Cancer Lett 296: 178-185.
42. Taranger CK, Noer A, SÃrensen AL, HÃkelien AM, Boquest AC, Collas P,. 2005. Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Mol Biol Cell 16: 5719-5735.
43. Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S,. 2006. Human umbilical cord matrix stem cells: Preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 24: 781-792.
44. Wong VL, Rieman DJ, Aronson L, Dalton BJ, Greig R, Anzano MA,. 1989. Growth-inhibitory activity of interferon-beta against human colorectal carcinoma cell lines. Int J Cancer 43: 526-530.
45. Yen BL, Yen ML,. 2008. Mesenchymal stem cells and cancer-For better or for worse? J Cancer Mol 4: 5-9.
46. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S,. 2004. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
47. Yuan Y, Liao YM, Hsueh CT, Mirshahidi HR,. 2011. Novel targeted therapeutics: Inhibitors of MDM2, ALK and PARP. J Hematol Oncol 4: 16.