-
1
-
-
0029807797
-
Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells
-
Diffley JF (1996) Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev 10:2819-2830.
-
(1996)
Genes Dev
, vol.10
, pp. 2819-2830
-
-
Diffley, J.F.1
-
2
-
-
0035812742
-
Making sense of eukaryotic DNA replication origins
-
Gilbert DM (2001) Making sense of eukaryotic DNA replication origins. Science 294: 96-100.
-
(2001)
Science
, vol.294
, pp. 96-100
-
-
Gilbert, D.M.1
-
3
-
-
2342618937
-
Replication origins: Why do we need so many?
-
Bielinsky AK (2003) Replication origins: Why do we need so many? Cell Cycle 2: 307-309.
-
(2003)
Cell Cycle
, vol.2
, pp. 307-309
-
-
Bielinsky, A.K.1
-
4
-
-
0035861492
-
Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: High-resolution mapping of replication origins
-
Wyrick JJ, et al. (2001) Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: High-resolution mapping of replication origins. Science 294:2357-2360.
-
(2001)
Science
, vol.294
, pp. 2357-2360
-
-
Wyrick, J.J.1
-
5
-
-
0032511148
-
Geminin, an inhibitor of DNA replication, is degraded during mitosis
-
DOI 10.1016/S0092-8674(00)81209-X
-
McGarry TJ, Kirschner MW (1998) Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-1053. (Pubitemid 28280797)
-
(1998)
Cell
, vol.93
, Issue.6
, pp. 1043-1053
-
-
McGarry, T.J.1
Kirschner, M.W.2
-
6
-
-
0034704221
-
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
-
DOI 10.1126/science.290.5500.2309
-
Wohlschlegel JA, et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290:2309-2312. (Pubitemid 32041574)
-
(2000)
Science
, vol.290
, Issue.5500
, pp. 2309-2312
-
-
Wohlschlegel, J.A.1
Dwyer, B.T.2
Dhar, S.K.3
Cvetic, C.4
Walter, J.C.5
Dutta, A.6
-
7
-
-
0035147434
-
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
-
DOI 10.1038/35055000
-
Tada S, Li A, Maiorano D, Méchali M, Blow JJ (2001) Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol 3:107-113. (Pubitemid 32118362)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.2
, pp. 107-113
-
-
Tada, S.1
Li, A.2
Maiorano, D.3
Mechali, M.4
Blow, J.J.5
-
8
-
-
0043234476
-
Skp2 ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
-
DOI 10.1074/jbc.C300251200
-
Li X, Zhao Q, Liao R, Sun P, Wu X (2003) The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem 278:30854-30858. (Pubitemid 36994595)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 30854-30858
-
-
Li, X.1
Zhao, Q.2
Liao, R.3
Sun, P.4
Wu, X.5
-
9
-
-
2342442851
-
Cyclin-dependent Kinases Phosphorylate Human Cdt1 and Induce Its Degradation
-
DOI 10.1074/jbc.C300549200
-
Liu E, Li X, Yan F, Zhao Q, Wu X (2004) Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem 279:17283-17288. (Pubitemid 38560487)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.17
, pp. 17283-17288
-
-
Liu, E.1
Li, X.2
Yan, F.3
Zhao, Q.4
Wu, X.5
-
10
-
-
2442427423
-
Cdt1 Phosphorylation by Cyclin A-dependent Kinases Negatively Regulates Its Function without Affecting Geminin Binding
-
DOI 10.1074/jbc.M313175200
-
Sugimoto N, et al. (2004) Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem 279: 19691-19697. (Pubitemid 38623406)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.19
, pp. 19691-19697
-
-
Sugimoto, N.1
Tatsumi, Y.2
Tsurumi, T.3
Matsukage, A.4
Kiyono, T.5
Nishitani, H.6
Fujita, M.7
-
11
-
-
78650670570
-
Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells
-
Ishii T, et al. (2010) Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells. J Biol Chem 285:41993-42000.
-
(2010)
J Biol Chem
, vol.285
, pp. 41993-42000
-
-
Ishii, T.1
-
12
-
-
33751227501
-
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
-
DOI 10.1101/gad.1482106
-
Sansam CL, et al. (2006) DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev 20:3117-3129. (Pubitemid 44790627)
-
(2006)
Genes and Development
, vol.20
, Issue.22
, pp. 3117-3129
-
-
Sansam, C.L.1
Shepard, J.L.2
Lai, K.3
Ianari, A.4
Danielian, P.S.5
Amsterdam, A.6
Hopkins, N.7
Lees, J.A.8
-
13
-
-
33747831132
-
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage
-
Higa LA, et al. (2006) L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Cell Cycle 5:1675-1680. (Pubitemid 44285255)
-
(2006)
Cell Cycle
, vol.5
, Issue.15
, pp. 1675-1680
-
-
Higa, L.A.1
Banks, D.2
Wu, M.3
Kobayashi, R.4
Sun, H.5
Zhang, H.6
-
14
-
-
33747873322
-
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1
-
DOI 10.1016/j.molcel.2006.08.010, PII S1097276506005703
-
Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006) A family of diverse Cul4-Ddb1- interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 23:709-721. (Pubitemid 44292562)
-
(2006)
Molecular Cell
, vol.23
, Issue.5
, pp. 709-721
-
-
Jin, J.1
Arias, E.E.2
Chen, J.3
Harper, J.W.4
Walter, J.C.5
-
15
-
-
33646504727
-
PCNA is a cofactor for CDT1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination
-
DOI 10.1074/jbc.M512705200
-
Senga T, et al. (2006) PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem 281:6246-6252. (Pubitemid 43847555)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.10
, pp. 6246-6252
-
-
Senga, T.1
Sivaprasad, U.2
Zhu, W.3
Jong, J.P.4
Arias, E.E.5
Walter, J.C.6
Dutta, A.7
-
16
-
-
41649105659
-
Cdh1
-
DOI 10.1091/mbc.E07-09-0859
-
Sugimoto N, et al. (2008) Identification of novel human Cdt1-binding proteins by a proteomics approach: Proteolytic regulation by APC/CCdh1. Mol Biol Cell 19: 1007-1021. (Pubitemid 351481815)
-
(2008)
Molecular Biology of the Cell
, vol.19
, Issue.3
, pp. 1007-1021
-
-
Sugimoto, N.1
Kitabayashi, I.2
Osano, S.3
Tatsumi, Y.4
Yugawa, T.5
Narisawa-Saito, M.6
Matsukage, A.7
Kiyono, T.8
Fujita, M.9
-
17
-
-
5444274523
-
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
-
DOI 10.1038/ncb1172
-
Hu J, McCall CM, Ohta T, Xiong Y (2004) Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol 6:1003-1009. (Pubitemid 39359854)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.10
, pp. 1003-1009
-
-
Hu, J.1
McCall, C.M.2
Ohta, T.3
Xiong, Y.4
-
18
-
-
3042686494
-
Skp2 complex
-
DOI 10.1074/jbc.M314023200
-
Kondo T, et al. (2004) Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J Biol Chem 279:27315-27319. (Pubitemid 38812571)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.26
, pp. 27315-27319
-
-
Kondo, T.1
Kobayashi, M.2
Tanaka, J.3
Yokoyama, A.4
Suzuki, S.5
Kato, N.6
Onozawa, M.7
Chiba, K.8
Hashino, S.9
Imamura, M.10
Minami, Y.11
Minamino, N.12
Asaka, M.13
-
19
-
-
2342542322
-
Regulation of Geminin and Cdt1 expression by E2F transcription factors
-
DOI 10.1038/sj.onc.1207488
-
Yoshida K, Inoue I (2004) Regulation of geminin and Cdt1 expression by E2F transcription factors. Oncogene 23:3802-3812. (Pubitemid 38725693)
-
(2004)
Oncogene
, vol.23
, Issue.21
, pp. 3802-3812
-
-
Yoshida, K.1
Inoue, I.2
-
20
-
-
20744458539
-
Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase
-
DOI 10.1074/jbc.M501208200
-
Takeda DY, Parvin JD, Dutta A (2005) Degradation of Cdt1 during S phase is Skp2- independent and is required for efficient progression of mammalian cells through S phase. J Biol Chem 280:23416-23423. (Pubitemid 40853256)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.24
, pp. 23416-23423
-
-
Takeda, D.Y.1
Parvin, J.D.2
Dutta, A.3
-
22
-
-
4143100474
-
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
-
DOI 10.1038/sj.emboj.7600314
-
Ballabeni A, et al. (2004) Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J 23:3122-3132. (Pubitemid 39093606)
-
(2004)
EMBO Journal
, vol.23
, Issue.15
, pp. 3122-3132
-
-
Ballabeni, A.1
Melixetian, M.2
Zamponi, R.3
Masiero, L.4
Marinoni, F.5
Helin, K.6
-
23
-
-
2542429354
-
Loss of Geminin induces rereplication in the presence of functional p53
-
DOI 10.1083/jcb.200403106
-
Melixetian M, et al. (2004) Loss of geminin induces rereplication in the presence of functional p53. J Cell Biol 165:473-482. (Pubitemid 38679613)
-
(2004)
Journal of Cell Biology
, vol.165
, Issue.4
, pp. 473-482
-
-
Melixetian, M.1
Ballabeni, A.2
Masiero, L.3
Gasparini, P.4
Zamponi, R.5
Bartek, J.6
Lukas, J.7
Helin, K.8
-
24
-
-
3543041247
-
2/M checkpoint
-
DOI 10.1128/MCB.24.16.7140-7150.2004
-
Zhu W, Chen Y, Dutta A (2004) Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. Mol Cell Biol 24:7140-7150. (Pubitemid 39014440)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.16
, pp. 7140-7150
-
-
Zhu, W.1
Chen, Y.2
Dutta, A.3
-
25
-
-
33645212112
-
An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage
-
DOI 10.1074/jbc.C500464200
-
Hu J, Xiong Y (2006) An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem 281:3753-3756. (Pubitemid 43847798)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.7
, pp. 3753-3756
-
-
Hu, J.1
Xiong, Y.2
-
26
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
DOI 10.1073/pnas.0400093101
-
Hosaka T, et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 101: 2975-2980. (Pubitemid 38327721)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.9
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs III, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
Arden, K.C.7
-
27
-
-
80052971895
-
PI3K-AKT-FoxO axis in cancer and aging
-
Tzivion G, Hay N (2011) PI3K-AKT-FoxO axis in cancer and aging. Biochim Biophys Acta 1813:1925.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1925
-
-
Tzivion, G.1
Hay, N.2
-
28
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
DOI 10.1038/sj.onc.1209086, PII 1209086
-
Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410-7425. (Pubitemid 41637981)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
29
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, et al. (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128:309-323.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
-
30
-
-
0037094096
-
Kip1 and Bim in response to IL-2
-
Stahl M, et al. (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 168:5024-5031. (Pubitemid 34495965)
-
(2002)
Journal of Immunology
, vol.168
, Issue.10
, pp. 5024-5031
-
-
Stahl, M.1
Dijkers, P.F.2
Kops, G.J.P.L.3
Lens, S.M.A.4
Coffer, P.J.5
Burgering, B.M.T.6
Medema, R.H.7
-
31
-
-
0036839685
-
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D
-
DOI 10.1128/MCB.22.22.7842-7852.2002
-
Schmidt M, et al. (2002) Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol 22:7842-7852. (Pubitemid 35217295)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.22
, pp. 7842-7852
-
-
Schmidt, M.1
De Mattos, S.F.2
Van Der, H.A.3
Klompmaker, R.4
Kops, G.J.P.L.5
Lam, E.W.-F.6
Burgering, B.M.T.7
Medema, R.H.8
-
32
-
-
70249146145
-
High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics
-
Santamaría CM, et al. (2009) High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics. Leuk Res 33:1706-1709.
-
(2009)
Leuk Res
, vol.33
, pp. 1706-1709
-
-
Santamaría, C.M.1
-
33
-
-
76249087423
-
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K, et al. (2010) TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463:676-680.
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
-
34
-
-
80052276420
-
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
-
Sykes SM, et al. (2011) AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell 146:697-708.
-
(2011)
Cell
, vol.146
, pp. 697-708
-
-
Sykes, S.M.1
-
35
-
-
33750361592
-
DDB1 maintains genome integrity through regulation of Cdt1
-
DOI 10.1128/MCB.00819-06
-
Lovejoy CA, Lock K, Yenamandra A, Cortez D (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 26:7977-7990. (Pubitemid 44630997)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.21
, pp. 7977-7990
-
-
Lovejoy, C.A.1
Lock, K.2
Yenamandra, A.3
Cortez, D.4
-
36
-
-
33644861713
-
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
-
DOI 10.1038/sj.emboj.7601002, PII 7601002
-
Nishitani H, et al. (2006) Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J 25:1126-1136. (Pubitemid 43372125)
-
(2006)
EMBO Journal
, vol.25
, Issue.5
, pp. 1126-1136
-
-
Nishitani, H.1
Sugimoto, N.2
Roukos, V.3
Nakanishi, Y.4
Saijo, M.5
Obuse, C.6
Tsurimoto, T.7
Nakayama, K.I.8
Nakayama, K.9
Fujita, M.10
Lygerou, Z.11
Nishimoto, T.12
-
37
-
-
51949098691
-
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
-
Abbas T, et al. (2008) PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev 22:2496-2506.
-
(2008)
Genes Dev
, vol.22
, pp. 2496-2506
-
-
Abbas, T.1
-
38
-
-
0036208817
-
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication
-
DOI 10.1016/S1097-2765(02)00467-7
-
Méndez J, et al. (2002) Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol Cell 9: 481-491. (Pubitemid 34273780)
-
(2002)
Molecular Cell
, vol.9
, Issue.3
, pp. 481-491
-
-
Mendez, J.1
Zou-Yang, X.H.2
Kim, S.-Y.3
Hidaka, M.4
Tansey, W.P.5
Stillman, B.6
|