In Vitro Studies of Composite Bone Filler Based on Poly(Propylene Fumarate) and Biphasic α-Tricalcium Phosphate/Hydroxyapatite Ceramic Powder

Artificial Organs

Volumn 36, Issue 4, 2012, Pages 418-428

  Wu, Chang Chin ^a,b,c   Yang, Kai Chiang ^d,e   Yang, Shu Hua ^c   Lin, Min Huei ^a   Kuo, Tzong Fu ^d   Lin, Feng Huei ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b EN CHU KONG HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Hydroxyapatite; Osteoporosis; Poly(methyl methacrylate); Poly(propylene fumarate); Vertebral fracture; Vertebroplasty

Indexed keywords

BIOCOMPATIBILITY; BONE; CERAMIC MATERIALS; COMPUTERIZED TOMOGRAPHY; CROSSLINKING; ESTERS; FILLERS; FRACTURE; FRACTURE TOUGHNESS; MIXTURES; POWDERS; PROPYLENE; RUBBER; TRANSMISSION CONTROL PROTOCOL;

FUMARATES; PHOSPHATE HYDROXYAPATITE; POLY(METHYL METHACRYLATE); POLY(PROPYLENE FUMARATE); POLY-METHYL METHACRYLATES; TRI-CALCIUM PHOSPHATES; VERTEBRAL FRACTURES; VERTEBROPLASTY;

HYDROXYAPATITE;

1 VINYL 2 PYRROLIDINONE; ALPHA TRICALCIUM PHOSPHATE CERAMIC; BENZOYL PEROXIDE; CALCIUM PHOSPHATE CERAMIC; FILLER; FUMARIC ACID DERIVATIVE; HYDROQUINONE; HYDROXYAPATITE; N,N DIMETHYL 4 METHYLANILINE; POLY(METHYL METHACRYLATE); POLY(PROPYLENE FUMARATE); TOLUIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; CELL PROLIFERATION; COMPOSITE MATERIAL; COMPRESSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DEGRADATION; HIGH TEMPERATURE; IN VITRO STUDY; LOW TEMPERATURE; OPTICAL DENSITY; PH; POWDER; PRIORITY JOURNAL; SYNTHESIS; TIME;

EID: 84859568511     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2011.01372.x     Document Type: Article

References (33)

1. Pearson D, Miller C. Clinical Trials in Osteoporosis. London: Springer-Verlag London Ltd, 2007;189-233.
2. Peterlik M. Aging, neuroendocrine function, and osteoporosis. Exp Gerontol 1997;32:577-86.
3. Lindsay R. The menopause and osteoporosis. Obstet Gynecol 1996;87:16-9.
4. Riggs BL, Melton LJ. The worldwide problem of osteoporosis: insight afforded by epidemiology. Bone 1995;17:505-11.
5. Devine A. Who are candidates for prevention and treatment for osteoporosis? Osteoporos Int 1997;7:1-6.
6. Wark JD. Osteoporosis: pathogenesis, diagnosis, prevention and management. Baillieres Clin Endocrinol Metab 1993;7:151-81.
7. Galibert P, Deramond H, Rosat P, etal. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 1987;33:166-8.
8. Wu CC, Lin MH, Yang SH, etal. Surgical removal of extravasated epidural and neuroforaminal polymethylmethacrylate after percutaneous vertebroplasty in the thoracic spine. Eur Spine J 2007;16(Suppl. 3):326-31.
9. Kim SH, Kang HS, Choi JA, etal. Risk factors of new compression fracture in adjacent vertebrae after percutanous vertebroplasty. Acta Radiol 2004;45:440-5.
10. Hulme PA, Krebs J, Ferguson SJ, etal. Vertebroplasty and kyphoplasty: a systemic review of 69 clinical studies. Spine 2006;31:1983-2001.
11. Nussbaum DA, Gailloud P, Murphy K. A review of complications associated with vertebroplasty and kyphoplasty as reported to the Food and Drug Administration medical device related web site. J Vasc Interv Radiol 2004;15:1185-92.
12. Nouda S, Tomita S, Kin A, etal. Adjacent vertebral body fracture following vertebroplasty with polymethylmethacrylate or calcium phosphate cement. Spine 2009;34:2613-8.
13. Huang KY, Yan JJ, Lin RM. Histopathologic findings of retrieved specimens of vertebroplasty with polymethylmethacrylate cement. Spine 2005;30:585-8.
14. Lieberman IH, Togawa D, Kayanja MM. Vertebroplasty and kyphoplasty: filler materials. Spine J 2005;5:305-16.
15. Nakano M, Hirano N, Ishihara H, etal. Calcium phosphate cement leakage after percutaneous vertebroplasty for osteoporotic vertebral fractures: risk factor analysis for cement leakage. J Neurosurg Spine 2005;2:27-33.
16. Masaki K, Keiichi M, Daniel EW, etal. In vitro stability of biphasic calcium phosphate ceramics. Biomaterials 1993;14:299-304.
17. Timmer MD, Carter C, Ambrose CG, etal. Fabrication of poly(propylene fumarate)-based orthopaedic implants by photo-crosslinking through transparent silicone molds. Biomaterials 2003;24:4707-14.
18. Lewandrowski KU, Bondre SP, Wise DL, etal. Enhanced bioactivity of a poly(propylene fumarate) bone graft substitute by augmentation with nano-hydroxyapatite. Biomed Mater Eng 2003;13:115-24.
19. He S, Yaszemski MJ, Yasko AW, etal. Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-demethacrylate. Biomaterials 2000;21:2389-94.
20. Verlaan JJ, Oner FC, Dhert WJA. Anterior spinal column augmentation with injectable bone cement. Biomaterials 2006;27:290-301.
21. Temenoff JS, Mikos AJ. Injectable biodegradable materials for orthopedic tissue engineering. Biomaterials 2000;21:2405-12.
22. Shung AK, Timmer MD, Jo S, etal. Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J Biomater Sci Polym Ed 2002;13:95-108.
23. Paynea RG, McGoniglea JS, Yaszemskib MJ, etal. Development of an injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations. Part 2. Viability of encapsulated marrow stromal osteoblasts cultured on crosslinking poly(propylene fumarate). Biomaterials 2002;23:4373-80.
24. Aoki H. Medical Applications of Hydroxyapatite. Tokyo, St Louis: Ishiyaku EuroAmerica, 1994.
25. Lin FH, Liao CJ, Chen KS, etal. Petal-like apatite formed on the surface of tricalcium phosphate ceramic after soaking in distilled water. Biomaterials 2001;22:2981-92.
26. Gangi A, Kastler BA, Dietemann JL. Percutaneous vertebroplasty guided by a combination of CT and fluoroscopy. AJNR Am J Neuroradiol 1994;15:83-6.
27. Golfman LW. Principles of CT and CT technology. J Nucl Med Technol 2007;35:115-28.
28. Yaszemski MJ, Payne R, Hayes WC, etal. In vitro degradation of a poly(propylene fumarate)-based composite materials. Biomaterials 1996;17:2127-30.
29. Turner TM, Urban RM, Singh K, etal. Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model. Spine J 2008;8:482-7.
30. Grafe IA, Baier M, Nöldge G, etal. Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures. Spine 2008;33:1284-90.
31. Domb AJ, Manor N, Elmalak O. Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt composition. Biomaterials 1996;17:411-7.
32. Peter SJ, Kim P, Yasko AW, etal. Crosslinking characteristics of an injectable poly(propylene fumarate)/beta-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. J Biomed Mater Res 1999;44:314-21.
33. Peter SJ, Lu L, Kim DJ, etal. Marrow stromal osteoblast function on a poly(propylene fumarate)/beta-tricalcium phosphate biodegradable orthopedic composite. Biomaterials 2000;21:1207-13.