Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt compositions

Biomaterials

Volumn 17, Issue 4, 1996, Pages 411-417

  Domb, Abraham J ^a   Manor, Nitza ^a   Elmalak, Omar ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Biodegradable polymers; Bone cement; Poly(propylene fumarate); Polymer composites

Indexed keywords

ABSORPTION; BIODEGRADATION; CALCIUM COMPOUNDS; CATALYSTS; COMPOSITION; COMPRESSIVE STRENGTH; CONDENSATION REACTIONS; DERIVATIVES; OLEFINS; OLIGOMERS; POLYMERIZATION; SALTS;

ACRYLATES; BIODEGRADABLE BONE CEMENT; BIODEGRADABLE POLYMERS; BONE FRACTURE; EPOXIDE; POLYPROPYLENE FUMARATE;

BONE CEMENT;

ACRYLIC ACID; BONE CEMENT; CALCIUM CARBONATE; CALCIUM PHOSPHATE; CALCIUM SALT; EPOXIDE; OLIGOMER; POLYPROPYLENE;

ARTICLE; BIODEGRADATION; BONE GROWTH; CROSS LINKING; FRACTURE; FRACTURE HEALING; HYDROLYSIS; ORTHOPEDIC SURGERY; POLYMERIZATION; PRIORITY JOURNAL;

EID: 0030088048     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/0142-9612(96)89657-8     Document Type: Article

References (14)

1. Domb AJ. Poly(propylene glycol fumarate) composition for biomedical applications. US Patent 4,888,413, August 1989.
2. Ibay AC, Whalley CE, Miller RA, Carr H, Jr., Battistone GC. Synthesis and properties of polymers for biodegradable implants. Polym Mater Sci Eng 1985; 53: 505.
3. Gerhart TN, Renshaw AA, Miller RL, Noecker RJ, Hayes WC. In vivo histological and biomechanical characterization of biodegradable particulate composite bone cement. J Biomed Mater Res 1989; 23: 1.
4. Domb AJ, Laurencin CT, Israeli O, Gerhart TN, Langer R. The formation of propylene fumarate oligomers for use in bioerodible bone cement composites. J Polym Sci A, 1990; 28: 973.
5. Storey RF, Warren SC, Allison CJ, Wiggins JF, Puckett AD. Synthesis of bioabsorbable networks from methacrylate-endcapped polyesters. Polymer 1993; 34: 4365.
6. Gerhart TN, Miller RL, Kleshinski SJ, Hayes WC. In vitro characterization and biomechanical optimization of biodegradable particulate bone cement. J Biomed Mater Res 1988; 22: 1071.
7. Klein CP, Driessen AA, de-Groot K, van den Hooff A. Biodegradation behavior of various calcium phosphate materials in bone tissue. J Biomed Mater Res 1983; 17: 769-784.
8. Wise DL (ed.) Biopolymer Controlled Release Systems. New York: ACS Press, 1986: 17.
9. Witschger PM, Gerhart TN, Goldman JB, Edsberg LE, Hayes WC. Biomechanical evaluation of a biodegradable composite as an adjunct to internal fixation of proximal femur fractures. J Orthop Res 1991; 9: 48.
10. Mark HF (ed.) Encyclopedia of Polymer Science and Technology Vol 11. New York: Interscience, 1969: 134.
11. Radomsky ML, Brouwer G, Floy BJ et al. The controlled release of Genirelix from the Atrigel injectable implant system. Proc Int Symp Control Rel Bioact Mater 1993; 20: 458.
12. Dreyfuss P, Dreyfuss MP. In: Frisch KC, Reegen SL (eds). Ring Opening Polymerization. New York: Dekker, 1969.
13. Goldstein SA, Wilson DL, Sonstegard DA, Matthews LS. The mechanical properties of human tibial trabecular bone as a function of metaphyseal location. J Biomech 1983; 16: 965-966.
14. Carter DR, Hayes WC. Bone compressive strength: The influence of density and strain rate. Science 1976; 194: 1174.