In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it

Cell Death and Differentiation

Volumn 19, Issue 5, 2012, Pages 808-815

  Moujalled, D M ^a,b   Cook, W D ^a   Lluis, J M ^a   Khan, N R ^a   Ahmed, A U ^c   Callus, B A ^d,e   Vaux, D L ^a,b,f  

^a LA TROBE UNIVERSITY   (Australia)

^b Department of Civil and Environmental Engineering   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

apoptosis; caspase 8; FLIP; NF B; smac mimetic

Indexed keywords

CASPASE 8; CYSTEINE PROTEINASE INHIBITOR; FAS LIGAND; FLICE INHIBITORY PROTEIN; FLIP L PROTEIN; FLIP P43 PROTEIN; FLIP R PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P56; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FIBROBLAST; GENE DELETION; GENOTYPE; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL DEATH; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; MICE; NF-KAPPA B; PROTEIN ISOFORMS; TUMOR NECROSIS FACTOR-ALPHA;

INTRACISTERNAL A-PARTICLES; MUS;

EID: 84859562184     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.151     Document Type: Article

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